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swp-1 Protein SWAP;SURP motif domain-containing protein;Suppressor of white apricot N-terminal domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 175795, updated on 23-Jan-2025

Summary

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Official Symbol
swp-1
Official Full Name
Protein SWAP;SURP motif domain-containing protein;Suppressor of white apricot N-terminal domain-containing protein
Primary source
WormBase:WBGene00006359
Locus tag
CELE_B0336.9
See related
AllianceGenome:WB:WBGene00006359
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable RNA binding activity. Predicted to be involved in mRNA 5'-splice site recognition. Orthologous to human SFSWAP (splicing factor SWAP). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See swp-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
8
Sequence:
Chromosome: III; NC_003281.10 (5702206..5705464, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Transcription initiation factor IIA small chain homolog Neighboring gene THAP-type domain-containing protein Neighboring gene Ubiquitin-like protein atg-12 Neighboring gene RGS domain-containing protein;Regulator of G-protein signaling rgs-5 Neighboring gene Large ribosomal subunit protein uL14 Neighboring gene Major sperm protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. SWAP pre-mRNA splicing regulators are a novel, ancient protein family sharing a highly conserved sequence motif with the prp21 family of constitutive splicing proteins. Spikes DA, et al. Nucleic Acids Res, 1994 Oct 25. PMID 7971282, Free PMC Article
  2. Alternative splicing and the steady-state ratios of mRNA isoforms generated by it are under strong stabilizing selection in Caenorhabditis elegans. Barberan-Soler S, et al. Mol Biol Evol, 2008 Nov. PMID 18718918, Free PMC Article
  3. High qualitative and quantitative conservation of alternative splicing in Caenorhabditis elegans and Caenorhabditis briggsae. Rukov JL, et al. Mol Biol Evol, 2007 Apr. PMID 17272679
  4. Identification and characterization of novel nicotinic receptor-associated proteins in Caenorhabditis elegans. Gottschalk A, et al. EMBO J, 2005 Jul 20. PMID 15990870, Free PMC Article
  5. Automated profiling of gene function during embryonic development. Green RA, et al. Cell, 2024 Jun 6. PMID 38759650,

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in RNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA 5'-splice site recognition IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Protein SWAP;SURP motif domain-containing protein;Suppressor of white apricot N-terminal domain-containing protein
NP_001021122.1
  • Confirmed by transcript evidence
NP_001367326.1
  • Confirmed by transcript evidence
NP_001379554.1
  • Confirmed by transcript evidence
NP_001379555.1
  • Confirmed by transcript evidence
NP_741149.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    5702206..5705464 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001379724.2 → NP_001367326.1  Protein SWAP [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (2) summary
    smart00648
    Location:80 → 134
    SWAP; Suppressor-of-White-APricot splicing regulator
    pfam09750
    Location:1 → 44
    DRY_EERY; Alternative splicing regulator

  2. NM_171132.4 → NP_741149.1  Protein SWAP [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741149.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q10580, Q17484, Q8WQH0
    Conserved Domains (2) summary
    smart00648
    Location:164 → 218
    SWAP; Suppressor-of-White-APricot splicing regulator
    pfam09750
    Location:18 → 128
    DRY_EERY; Alternative splicing regulator

  3. NM_001392108.1 → NP_001379554.1  Suppressor of white apricot N-terminal domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2KY77
    Conserved Domains (1) summary
    pfam09750
    Location:22 → 61
    DRY_EERY; Alternative splicing regulator

  4. NM_001025951.3 → NP_001021122.1  SURP motif domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021122.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MPQ0
    Conserved Domains (2) summary
    smart00648
    Location:168 → 222
    SWAP; Suppressor-of-White-APricot splicing regulator
    pfam09750
    Location:22 → 132
    DRY_EERY; Alternative splicing regulator

  5. NM_001392107.1 → NP_001379555.1  Suppressor of white apricot N-terminal domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2KY78
    Conserved Domains (1) summary
    pfam09750
    Location:22 → 60
    DRY_EERY; Alternative splicing regulator
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q10580.1

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