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Conserved domains on  [gi|25151783|ref|NP_741149|]
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Protein SWAP [Caenorhabditis elegans]

Protein Classification

DRY_EERY and SWAP domain-containing protein( domain architecture ID 10560971)

DRY_EERY and SWAP domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DRY_EERY pfam09750
Alternative splicing regulator; This entry represents the conserved N-terminal region of SWAP ...
 18-128 3.03e-26

Alternative splicing regulator; This entry represents the conserved N-terminal region of SWAP (suppressor-of-white-apricot protein) proteins. This region contains two highly conserved motifs, viz: DRY and EERY, which appear to be the sites for alternative splicing of exons 2 and 3 of the SWAP mRNA. These proteins are thus thought to be involved in auto-regulation of pre-mRNA splicing. Most family members are associated with two Surp domains pfam01805 and an Arginine- serine-rich binding region towards the C-terminus.


:

Pssm-ID: 462881  Cd Length: 129  Bit Score: 104.32  E-value: 3.03e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25151783    18 LLVFGYASTIFPNDYQSEHIAEERHTVPCLGDPENRVDRYDCRLLLPSIDVAIK-RNGSPSEQCPTEAMEEDMCEEERYL 96
Cdd:pfam09750   1 LQVFGRRCKLFRDDAIAAAAESGKHLVPWQGDPDLLIDRFDVRALLDDIPEYEAgRSARLSELTSEEEEEERECNYERYR 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 25151783    97 DMYKDI-----------------QREQEKEEEEKRRNDQRNAIGFDYGT 128
Cdd:pfam09750  81 DLIKNEfegvseeeelkriyqeeQFGAKRLSAAKKSSGSYAAIGFSYDD 129
SWAP smart00648
Suppressor-of-White-APricot splicing regulator; domain present in regulators which are ...
 164-218 3.63e-13

Suppressor-of-White-APricot splicing regulator; domain present in regulators which are responsible for pre-mRNA splicing processes


:

Pssm-ID: 197818 [Multi-domain]  Cd Length: 54  Bit Score: 64.53  E-value: 3.63e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 25151783    164 HHIIEKTASFIVANGTQMEIVIKAKQRNNAeQFGFLEFDHRLNPFYKYLQKLIRE 218
Cdd:smart00648   1 LDIIDKTAQFVARNGPEFEAKLMERERNNP-QFDFLKPNDPYHAYYRKKLAEYRQ 54
SWAP smart00648
Suppressor-of-White-APricot splicing regulator; domain present in regulators which are ...
 390-440 8.36e-10

Suppressor-of-White-APricot splicing regulator; domain present in regulators which are responsible for pre-mRNA splicing processes


:

Pssm-ID: 197818 [Multi-domain]  Cd Length: 54  Bit Score: 54.90  E-value: 8.36e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 25151783    390 PILNSYAEHVAQRGLEAEASLAARE--DLQLHFMEPKSPYYSYYHHKVRMHQW 440
Cdd:smart00648   2 DIIDKTAQFVARNGPEFEAKLMERErnNPQFDFLKPNDPYHAYYRKKLAEYRQ 54
 
Name Accession Description Interval E-value
DRY_EERY pfam09750
Alternative splicing regulator; This entry represents the conserved N-terminal region of SWAP ...
 18-128 3.03e-26

Alternative splicing regulator; This entry represents the conserved N-terminal region of SWAP (suppressor-of-white-apricot protein) proteins. This region contains two highly conserved motifs, viz: DRY and EERY, which appear to be the sites for alternative splicing of exons 2 and 3 of the SWAP mRNA. These proteins are thus thought to be involved in auto-regulation of pre-mRNA splicing. Most family members are associated with two Surp domains pfam01805 and an Arginine- serine-rich binding region towards the C-terminus.


Pssm-ID: 462881  Cd Length: 129  Bit Score: 104.32  E-value: 3.03e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25151783    18 LLVFGYASTIFPNDYQSEHIAEERHTVPCLGDPENRVDRYDCRLLLPSIDVAIK-RNGSPSEQCPTEAMEEDMCEEERYL 96
Cdd:pfam09750   1 LQVFGRRCKLFRDDAIAAAAESGKHLVPWQGDPDLLIDRFDVRALLDDIPEYEAgRSARLSELTSEEEEEERECNYERYR 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 25151783    97 DMYKDI-----------------QREQEKEEEEKRRNDQRNAIGFDYGT 128
Cdd:pfam09750  81 DLIKNEfegvseeeelkriyqeeQFGAKRLSAAKKSSGSYAAIGFSYDD 129
SWAP smart00648
Suppressor-of-White-APricot splicing regulator; domain present in regulators which are ...
 164-218 3.63e-13

Suppressor-of-White-APricot splicing regulator; domain present in regulators which are responsible for pre-mRNA splicing processes


Pssm-ID: 197818 [Multi-domain]  Cd Length: 54  Bit Score: 64.53  E-value: 3.63e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 25151783    164 HHIIEKTASFIVANGTQMEIVIKAKQRNNAeQFGFLEFDHRLNPFYKYLQKLIRE 218
Cdd:smart00648   1 LDIIDKTAQFVARNGPEFEAKLMERERNNP-QFDFLKPNDPYHAYYRKKLAEYRQ 54
Surp pfam01805
Surp module; This domain is also known as the SWAP domain. SWAP stands for ...
 166-212 7.42e-12

Surp module; This domain is also known as the SWAP domain. SWAP stands for Suppressor-of-White-APricot. It has been suggested that these domains may be RNA binding.


Pssm-ID: 460339 [Multi-domain]  Cd Length: 52  Bit Score: 60.61  E-value: 7.42e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 25151783   166 IIEKTASFIVANGTQMEIVIKAKQRNNAeQFGFL-EFDHRLNPFYKYL 212
Cdd:pfam01805   2 IIKKTAQFVARNGPEFEALLMEREERNP-QFDFLfDPDDPLHAYYRWK 48
SWAP smart00648
Suppressor-of-White-APricot splicing regulator; domain present in regulators which are ...
 390-440 8.36e-10

Suppressor-of-White-APricot splicing regulator; domain present in regulators which are responsible for pre-mRNA splicing processes


Pssm-ID: 197818 [Multi-domain]  Cd Length: 54  Bit Score: 54.90  E-value: 8.36e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 25151783    390 PILNSYAEHVAQRGLEAEASLAARE--DLQLHFMEPKSPYYSYYHHKVRMHQW 440
Cdd:smart00648   2 DIIDKTAQFVARNGPEFEAKLMERErnNPQFDFLKPNDPYHAYYRKKLAEYRQ 54
Surp pfam01805
Surp module; This domain is also known as the SWAP domain. SWAP stands for ...
 396-435 5.62e-05

Surp module; This domain is also known as the SWAP domain. SWAP stands for Suppressor-of-White-APricot. It has been suggested that these domains may be RNA binding.


Pssm-ID: 460339 [Multi-domain]  Cd Length: 52  Bit Score: 40.96  E-value: 5.62e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 25151783   396 AEHVAQRGLEAEASLAARE--DLQLHFM-EPKSPYYSYYHHKV 435
Cdd:pfam01805   7 AQFVARNGPEFEALLMEREerNPQFDFLfDPDDPLHAYYRWKL 49
 
Name Accession Description Interval E-value
DRY_EERY pfam09750
Alternative splicing regulator; This entry represents the conserved N-terminal region of SWAP ...
 18-128 3.03e-26

Alternative splicing regulator; This entry represents the conserved N-terminal region of SWAP (suppressor-of-white-apricot protein) proteins. This region contains two highly conserved motifs, viz: DRY and EERY, which appear to be the sites for alternative splicing of exons 2 and 3 of the SWAP mRNA. These proteins are thus thought to be involved in auto-regulation of pre-mRNA splicing. Most family members are associated with two Surp domains pfam01805 and an Arginine- serine-rich binding region towards the C-terminus.


Pssm-ID: 462881  Cd Length: 129  Bit Score: 104.32  E-value: 3.03e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25151783    18 LLVFGYASTIFPNDYQSEHIAEERHTVPCLGDPENRVDRYDCRLLLPSIDVAIK-RNGSPSEQCPTEAMEEDMCEEERYL 96
Cdd:pfam09750   1 LQVFGRRCKLFRDDAIAAAAESGKHLVPWQGDPDLLIDRFDVRALLDDIPEYEAgRSARLSELTSEEEEEERECNYERYR 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 25151783    97 DMYKDI-----------------QREQEKEEEEKRRNDQRNAIGFDYGT 128
Cdd:pfam09750  81 DLIKNEfegvseeeelkriyqeeQFGAKRLSAAKKSSGSYAAIGFSYDD 129
SWAP smart00648
Suppressor-of-White-APricot splicing regulator; domain present in regulators which are ...
 164-218 3.63e-13

Suppressor-of-White-APricot splicing regulator; domain present in regulators which are responsible for pre-mRNA splicing processes


Pssm-ID: 197818 [Multi-domain]  Cd Length: 54  Bit Score: 64.53  E-value: 3.63e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 25151783    164 HHIIEKTASFIVANGTQMEIVIKAKQRNNAeQFGFLEFDHRLNPFYKYLQKLIRE 218
Cdd:smart00648   1 LDIIDKTAQFVARNGPEFEAKLMERERNNP-QFDFLKPNDPYHAYYRKKLAEYRQ 54
Surp pfam01805
Surp module; This domain is also known as the SWAP domain. SWAP stands for ...
 166-212 7.42e-12

Surp module; This domain is also known as the SWAP domain. SWAP stands for Suppressor-of-White-APricot. It has been suggested that these domains may be RNA binding.


Pssm-ID: 460339 [Multi-domain]  Cd Length: 52  Bit Score: 60.61  E-value: 7.42e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 25151783   166 IIEKTASFIVANGTQMEIVIKAKQRNNAeQFGFL-EFDHRLNPFYKYL 212
Cdd:pfam01805   2 IIKKTAQFVARNGPEFEALLMEREERNP-QFDFLfDPDDPLHAYYRWK 48
SWAP smart00648
Suppressor-of-White-APricot splicing regulator; domain present in regulators which are ...
 390-440 8.36e-10

Suppressor-of-White-APricot splicing regulator; domain present in regulators which are responsible for pre-mRNA splicing processes


Pssm-ID: 197818 [Multi-domain]  Cd Length: 54  Bit Score: 54.90  E-value: 8.36e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 25151783    390 PILNSYAEHVAQRGLEAEASLAARE--DLQLHFMEPKSPYYSYYHHKVRMHQW 440
Cdd:smart00648   2 DIIDKTAQFVARNGPEFEAKLMERErnNPQFDFLKPNDPYHAYYRKKLAEYRQ 54
Surp pfam01805
Surp module; This domain is also known as the SWAP domain. SWAP stands for ...
 396-435 5.62e-05

Surp module; This domain is also known as the SWAP domain. SWAP stands for Suppressor-of-White-APricot. It has been suggested that these domains may be RNA binding.


Pssm-ID: 460339 [Multi-domain]  Cd Length: 52  Bit Score: 40.96  E-value: 5.62e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 25151783   396 AEHVAQRGLEAEASLAARE--DLQLHFM-EPKSPYYSYYHHKV 435
Cdd:pfam01805   7 AQFVARNGPEFEALLMEREerNPQFDFLfDPDDPLHAYYRWKL 49
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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