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pqe-1 Putative RNA exonuclease pqe-1 [ Caenorhabditis elegans ]

Gene ID: 175731, updated on 4-Jan-2025

Summary

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Official Symbol
pqe-1
Official Full Name
Putative RNA exonuclease pqe-1
Primary source
WormBase:WBGene00004095
Locus tag
CELE_F52C9.8
See related
AllianceGenome:WB:WBGene00004095
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable exonuclease activity. Involved in negative regulation of gene expression. Located in nucleus. Is expressed in intestine and nervous system. Orthologous to several human genes including REXO1 (RNA exonuclease 1 homolog). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See pqe-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
14
Sequence:
Chromosome: III; NC_003281.10 (5311240..5321745)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene tRNA-Thr Neighboring gene ncRNA Neighboring gene Pre-mRNA-splicing factor CWC25 homolog Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene Suppressor of organelle fusion 2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Selective inhibitors of death in mutant huntingtin cells. Varma H, et al. Nat Chem Biol, 2007 Feb. PMID 17195849
  2. Mutations in the pqe-1 gene enhance transgene expression in Caenorhabditis elegans. Yamada K, et al. G3 (Bethesda), 2012 Jul. PMID 22870397, Free PMC Article
  3. Identification of potential therapeutic drugs for huntington's disease using Caenorhabditis elegans. Voisine C, et al. PLoS One, 2007 Jun 6. PMID 17551584, Free PMC Article
  4. Glutamine/proline-rich PQE-1 proteins protect Caenorhabditis elegans neurons from huntingtin polyglutamine neurotoxicity. Faber PW, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12486229, Free PMC Article
  5. Active turnover modulates mature microRNA activity in Caenorhabditis elegans. Chatterjee S, et al. Nature, 2009 Sep 24. PMID 19734881

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables exonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables exonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in rRNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Putative RNA exonuclease pqe-1
NP_001040854.1
  • Confirmed by transcript evidence
NP_001370742.1
  • Confirmed by transcript evidence
NP_498135.2
  • Confirmed by transcript evidence
NP_498136.2
  • Confirmed by transcript evidence
NP_741135.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    5311240..5321745
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_065734.9 → NP_498135.2  Putative RNA exonuclease pqe-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_498135.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G8JYC4, Q10124, Q8MQ26, Q8MQ27, Q8MQ28, Q8MQ29, Q8MQ30, Q8MQ31
    Conserved Domains (4) summary
    cd06145
    Location:1479 → 1629
    REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
    PHA03160
    Location:285 → 405
    PHA03160; hypothetical protein; Provisional
    smart00818
    Location:377 → 502
    Amelogenin; Amelogenins, cell adhesion proteins, play a role in the biomineralisation of teeth
    pfam15870
    Location:1230 → 1364
    EloA-BP1; ElonginA binding-protein 1

  2. NM_065735.7 → NP_498136.2  Putative RNA exonuclease pqe-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_498136.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q10124
    Conserved Domains (2) summary
    cd06145
    Location:502 → 652
    REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
    pfam15870
    Location:253 → 387
    EloA-BP1; ElonginA binding-protein 1

  3. NM_001382869.2 → NP_001370742.1  Putative RNA exonuclease pqe-1 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (1) summary
    PHA03247
    Location:131 → 497
    PHA03247; large tegument protein UL36; Provisional

  4. NM_001047389.4 → NP_001040854.1  Putative RNA exonuclease pqe-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001040854.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G8JYC4
    Conserved Domains (4) summary
    cd06145
    Location:504 → 654
    REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
    pfam06991
    Location:171 → 208
    MFAP1; Microfibril-associated/Pre-mRNA processing
    pfam15870
    Location:255 → 387
    EloA-BP1; ElonginA binding-protein 1
    pfam16602
    Location:91 → 180
    USP19_linker; Linker region of USP19 deubiquitinase

  5. NM_171120.6 → NP_741135.1  Putative RNA exonuclease pqe-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741135.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q10124
    Conserved Domains (1) summary
    cd06145
    Location:272 → 422
    REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q10124.2

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