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cup-14 RUN domain-containing protein;Rubicon Homology domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 175037, updated on 4-Jan-2025

Summary

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Official Symbol
cup-14
Official Full Name
RUN domain-containing protein;Rubicon Homology domain-containing protein
Primary source
WormBase:WBGene00013093
Locus tag
CELE_Y51H1A.2
See related
AllianceGenome:WB:WBGene00013093
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable metal ion binding activity. Involved in lysosome organization. Predicted to be located in endosome. Human ortholog(s) of this gene implicated in autosomal recessive osteopetrosis 6 and osteopetrosis. Orthologous to several human genes including PLEKHM1 (pleckstrin homology and RUN domain containing M1). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See cup-14 in Genome Data Viewer
Location:
chromosome: II
Exon count:
14
Sequence:
Chromosome: II; NC_003280.10 (13855785..13872241, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial Neighboring gene Inhibitor of growth protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Regulators of Lysosome Function and Dynamics in Caenorhabditis elegans. Gee K, et al. G3 (Bethesda), 2017 Mar 10. PMID 28122949, Free PMC Article
  2. DPL-1 DP, LIN-35 Rb and EFL-1 E2F act with the MCD-1 zinc-finger protein to promote programmed cell death in Caenorhabditis elegans. Reddien PW, et al. Genetics, 2007 Apr. PMID 17237514, Free PMC Article
  3. A BORC-dependent molecular pathway for vesiculation of cell corpse phagolysosomes. Fazeli G, et al. Curr Biol, 2023 Feb 27. PMID 36652947, Free PMC Article
  4. Molecular definitions of autophagy and related processes. Galluzzi L, et al. EMBO J, 2017 Jul 3. PMID 28596378, Free PMC Article
  5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in autophagy IEA
Inferred from Electronic Annotation
more info
  
involved_in lysosome organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in endosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
RUN domain-containing protein;Rubicon Homology domain-containing protein
NP_001254407.1
  • Confirmed by transcript evidence
NP_001254408.1
  • Confirmed by transcript evidence
NP_001254409.1
  • Confirmed by transcript evidence
NP_001254410.1
  • Confirmed by transcript evidence
NP_001254411.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    13855785..13872241 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001267480.3 → NP_001254409.1  Rubicon Homology domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001254409.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    K8ESG4
    Conserved Domains (1) summary
    pfam13901
    Location:260 → 457
    zf-RING_9; Putative zinc-RING and/or ribbon

  2. NM_001267481.4 → NP_001254410.1  Rubicon Homology domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001254410.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    K8ERZ0

  3. NM_001267478.2 → NP_001254407.1  RUN domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001254407.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    K8ESM7
    Conserved Domains (3) summary
    cl02475
    Location:709 → 748
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    pfam02759
    Location:62 → 185
    RUN; RUN domain
    pfam13901
    Location:735 → 932
    zf-RING_9; Putative zinc-RING and/or ribbon

  4. NM_001267479.3 → NP_001254408.1  RUN domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001254408.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    K8F804
    Conserved Domains (3) summary
    cl02475
    Location:699 → 738
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    pfam02759
    Location:52 → 175
    RUN; RUN domain
    pfam13901
    Location:725 → 922
    zf-RING_9; Putative zinc-RING and/or ribbon

  5. NM_001267482.3 → NP_001254411.1  Rubicon Homology domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001254411.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    K8FE08
    Conserved Domains (1) summary
    pfam13901
    Location:119 → 316
    zf-RING_9; Putative zinc-RING and/or ribbon
Nucleotide Protein
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