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ddx-19 RNA helicase [ Caenorhabditis elegans ]

Gene ID: 174418, updated on 9-Dec-2024

Summary

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Official Symbol
ddx-19
Official Full Name
RNA helicase
Primary source
WormBase:WBGene00011580
Locus tag
CELE_T07D4.4
See related
AllianceGenome:WB:WBGene00011580
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable RNA helicase activity and mRNA binding activity. Involved in germ cell development. Located in P granule. Is expressed in excretory cell; hypodermis; and tail. Orthologous to several human genes including DDX19A (DEAD-box helicase 19A) and DDX19B (DEAD-box helicase 19B). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ddx-19 in Genome Data Viewer
Location:
chromosome: II
Exon count:
14
Sequence:
Chromosome: II; NC_003280.10 (8884899..8889702)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene ATP-dependent RNA helicase A;RNA helicase Neighboring gene P53 and DNA damage-regulated protein 1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Perinuclear P granules are the principal sites of mRNA export in adult C. elegans germ cells. Sheth U, et al. Development, 2010 Apr. PMID 20223759, Free PMC Article
  2. Multiple ERK substrates execute single biological processes in Caenorhabditis elegans germ-line development. Arur S, et al. Proc Natl Acad Sci U S A, 2009 Mar 24. PMID 19264959, Free PMC Article
  3. In Vivo Interaction Proteomics in Caenorhabditis elegans Embryos Provides New Insights into P Granule Dynamics. Chen JX, et al. Mol Cell Proteomics, 2016 May. PMID 26912668, Free PMC Article
  4. SIN-3 acts in distinct complexes to regulate the germline transcriptional program in Caenorhabditis elegans. Robert VJ, et al. Development, 2023 Nov 1. PMID 37818613, Free PMC Article
  5. A modified TurboID approach identifies tissue-specific centriolar components in C. elegans. Holzer E, et al. PLoS Genet, 2022 Apr. PMID 35442950, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in germ cell development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in poly(A)+ mRNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in P granule IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasmic stress granule IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
RNA helicase
NP_001254186.1
  • Confirmed by transcript evidence
NP_001293467.1
  • Confirmed by transcript evidence
NP_495891.1
  • Confirmed by transcript evidence
NP_495892.1
  • Confirmed by transcript evidence
NP_495893.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    8884899..8889702
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_063492.2 → NP_495893.1  RNA helicase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_495893.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O62372
    Conserved Domains (3) summary
    PTZ00424
    Location:208 → 599
    PTZ00424; helicase 45; Provisional
    cd00079
    Location:428 → 575
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    cl21455
    Location:211 → 415
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  2. NM_063490.5 → NP_495891.1  RNA helicase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_495891.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q22308
    Conserved Domains (4) summary
    PTZ00424
    Location:617 → 1016
    PTZ00424; helicase 45; Provisional
    cd00079
    Location:837 → 984
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    pfam13634
    Location:158 → 247
    Nucleoporin_FG; Nucleoporin FG repeat region
    cl21455
    Location:620 → 824
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  3. NM_063491.6 → NP_495892.1  RNA helicase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_495892.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O18056, Q22309
    Conserved Domains (3) summary
    PTZ00424
    Location:233 → 624
    PTZ00424; helicase 45; Provisional
    cd00079
    Location:453 → 600
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    cl21455
    Location:236 → 440
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  4. NM_001267257.3 → NP_001254186.1  RNA helicase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001254186.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B7WN80
    Conserved Domains (3) summary
    PTZ00424
    Location:202 → 593
    PTZ00424; helicase 45; Provisional
    cd00079
    Location:422 → 569
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    cl21455
    Location:205 → 409
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  5. NM_001306538.4 → NP_001293467.1  RNA helicase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293467.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B7WN81
    Conserved Domains (3) summary
    PTZ00424
    Location:92 → 483
    PTZ00424; helicase 45; Provisional
    cd00079
    Location:312 → 459
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    cl21455
    Location:95 → 299
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
Nucleotide Protein
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