U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

jip-1 JNK-interacting protein 1;PID domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 173513, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
jip-1
Official Full Name
JNK-interacting protein 1;PID domain-containing protein
Primary source
WormBase:WBGene00002176
Locus tag
CELE_F56D12.4
See related
AllianceGenome:WB:WBGene00002176
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to several human genes including MAPK8IP1 (mitogen-activated protein kinase 8 interacting protein 1). [provided by Alliance of Genome Resources, Jan 2025]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See jip-1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
19
Sequence:
Chromosome: II; NC_003280.10 (1326989..1350132)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Hyaluronan/mRNA-binding protein domain-containing protein Neighboring gene tRNA Neighboring gene tRNA Neighboring gene tRNA Neighboring gene tRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene WSC domain-containing protein Neighboring gene Neuropeptide-Like Protein

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. An essential role of the JIP1 scaffold protein for JNK activation in adipose tissue. Jaeschke A, et al. Genes Dev, 2004 Aug 15. PMID 15314024, Free PMC Article
  2. The small GTPase RALA controls c-Jun N-terminal kinase-mediated FOXO activation by regulation of a JIP1 scaffold complex. van den Berg MC, et al. J Biol Chem, 2013 Jul 26. PMID 23770673, Free PMC Article
  3. Roles of MAP kinase cascades in Caenorhabditis elegans. Sakaguchi A, et al. J Biochem, 2004 Jul. PMID 15269234
  4. SH3 interactome conserves general function over specific form. Xin X, et al. Mol Syst Biol, 2013. PMID 23549480, Free PMC Article
  5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. identify JIP1 as a novel molecular target for therapeutic intervention in the development of obesity
    Title: An essential role of the JIP1 scaffold protein for JNK activation in adipose tissue.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

General protein information

Go to the top of the page Help
Preferred Names
JNK-interacting protein 1;PID domain-containing protein
NP_001033331.1
  • Confirmed by transcript evidence
NP_001033332.1
  • Confirmed by transcript evidence
NP_001364548.1
  • Confirmed by transcript evidence
NP_001364697.1
  • Confirmed by transcript evidence
NP_001407480.1
  • Partially confirmed by transcript evidence
NP_001407481.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    1326989..1350132
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001377692.2 → NP_001364548.1  PID domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A5S9MN04
    Conserved Domains (2) summary
    cd11801
    Location:772 → 826
    SH3_JIP1_like; Src homology 3 domain of JNK-interacting proteins 1 and 2, and similar domains
    cd01212
    Location:850 → 996
    PTB_JIP; JNK-interacting protein-like (JIP) Phosphotyrosine-binding (PTB) domain

  2. NM_001377691.2 → NP_001364697.1  PID domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    G4RZC8
    Conserved Domains (2) summary
    cd11801
    Location:777 → 831
    SH3_JIP1_like; Src homology 3 domain of JNK-interacting proteins 1 and 2, and similar domains
    cd01212
    Location:855 → 1001
    PTB_JIP; JNK-interacting protein-like (JIP) Phosphotyrosine-binding (PTB) domain

  3. NM_001038242.6 → NP_001033331.1  JNK-interacting protein 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001033331.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G4RZC9
    Conserved Domains (2) summary
    cd11801
    Location:298 → 352
    SH3_JIP1_like; Src homology 3 domain of JNK-interacting proteins 1 and 2, and similar domains
    cd01212
    Location:376 → 522
    PTB_JIP; JNK-interacting protein-like (JIP) Phosphotyrosine-binding (PTB) domain

  4. NM_001420585.1 → NP_001407481.1  JNK-interacting protein 1 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A5S9MQ27

  5. NM_001420586.1 → NP_001407480.1  JNK-interacting protein 1 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A5S9MNX6

  6. NM_001038243.6 → NP_001033332.1  JNK-interacting protein 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001033332.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O16643
    Conserved Domains (2) summary
    cd11801
    Location:144 → 198
    SH3_JIP1_like; Src homology 3 domain of JNK-interacting proteins 1 and 2, and similar domains
    cd01212
    Location:222 → 368
    PTB_JIP; JNK-interacting protein-like (JIP) Phosphotyrosine-binding (PTB) domain
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools