adamts13 ADAM metallopeptidase with thrombospondin type 1 motif, 13 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: adamts13provided by ZNC
Official Full Name: ADAM metallopeptidase with thrombospondin type 1 motif, 13provided by ZNC
Primary source: ZFIN:ZDB-GENE-070814-7
See related: Ensembl:ENSDARG00000076270 AllianceGenome:ZFIN:ZDB-GENE-070814-7
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary: Enables peptidase activity. Involved in proteolysis. Predicted to be located in extracellular region. Predicted to be active in extracellular matrix. Is expressed in blood plasma. Human ortholog(s) of this gene implicated in thrombotic thrombocytopenic purpura. Orthologous to human ADAMTS13 (ADAM metallopeptidase with thrombospondin type 1 motif 13). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 8

Exon count:: 30

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	8	NC_007119.7 (45226784..45279250, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	8	NC_007119.6 (45218910..45271360, complement)

Chromosome 8 - NC_007119.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Histone-induced thrombotic thrombocytopenic purpura in adamts13 (-/-) zebrafish depends on von Willebrand factor.
Title: Histone-induced thrombotic thrombocytopenic purpura in adamts13 (-/-) zebrafish depends on von Willebrand factor.

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General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metalloendopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metalloendopeptidase activity	IEA Inferred from Electronic Annotation more info
enables metallopeptidase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables peptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in extracellular matrix organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within extracellular matrix organization	IEA Inferred from Electronic Annotation more info
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: A disintegrin and metalloproteinase with thrombospondin motifs 13

XP_002663267.4

EC 3.4.24.87

XP_021327811.1

EC 3.4.24.87

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007119.7 Reference GRCz11 Primary Assembly

Range

45226784..45279250 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_002663221.7 → XP_002663267.4 A disintegrin and metalloproteinase with thrombospondin motifs 13

UniProtKB/TrEMBL

A0A286Y999, A0A8M1RM10

Related

ENSDARP00000143739.1, ENSDART00000175207.2

Conserved Domains (3) summary

smart00209
Location:520 → 572

TSP1; Thrombospondin type 1 repeats

cd04273
Location:219 → 420

ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...

pfam01421
Location:219 → 423

Reprolysin; Reprolysin (M12B) family zinc metalloprotease

Reference GRCz11 ALT_DRER_TU_1

Genomic

NW_018394741.1 Reference GRCz11 ALT_DRER_TU_1

Range

105004..164180 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021472136.2 → XP_021327811.1 A disintegrin and metalloproteinase with thrombospondin motifs 13

UniProtKB/TrEMBL

A0A8M9PZM1

Conserved Domains (2) summary

smart00209
Location:520 → 572

TSP1; Thrombospondin type 1 repeats

cd04273
Location:219 → 420

ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...