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Conserved domains on  [gi|688569121|ref|XP_002663267|]
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A disintegrin and metalloproteinase with thrombospondin motifs 13 [Danio rerio]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ZnMc_ADAMTS_like cd04273
Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) ...
 219-420 3.10e-89

Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that combine ADAM-like metalloproteinases with thrombospondin type-1 repeats. ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) proteinases are inhibited by TIMPs (tissue inhibitors of metalloproteinases), and they play roles in coagulation, angiogenesis, development and progression of arthritis. They hydrolyze the von Willebrand factor precursor and various components of the extracellular matrix.


:

Pssm-ID: 239801  Cd Length: 207  Bit Score: 288.37  E-value: 3.10e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688569121  219 YLELAVVVGPDVYEV-HRQDTERYILTNLNIASELLRDVTLGANIRVHLVRMIILTEPEPDIQISENITSSLKSVCEWGQ 297
Cdd:cd04273     2 YVETLVVADSKMVEFhHGEDLEHYILTLMNIVASLYKDPSLGNSINIVVVRLIVLEDEESGLLISGNAQKSLKSFCRWQK 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688569121  298 KVNPDADSDPLHADLLLYITRFDLVLPNGNKLVRGVTQFGGVCSTQWNCVITEDTGFDLGITIAHEIGHSFGINHDGIDN 377
Cdd:cd04273    82 KLNPPNDSDPEHHDHAILLTRQDICRSNGNCDTLGLAPVGGMCSPSRSCSINEDTGLSSAFTIAHELGHVLGMPHDGDGN 161

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 688569121  378 TCSSS---GFMMASDGGYNSVDLTWSQCSRAQLYSFFRAGKAECVQ 420
Cdd:cd04273   162 SCGPEgkdGHIMSPTLGANTGPFTWSKCSRRYLTSFLDTGDGNCLL 207
ADAMTS_spacer1 pfam05986
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like ...
 690-811 6.37e-38

ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like proteins. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase) and is a subfamily of the metalloprotease family, sharing a high degree of sequence similarity and conserved domain organization among its members. Members of the ADAM-TS family have been implicated in a range of diseases. ADAM-TS-like proteins lack a metalloprotease domain. They resides in the ECM and have regulatory roles. Examples of ADAM-TS-like proteins are papilin and punctin.


:

Pssm-ID: 461796  Cd Length: 115  Bit Score: 138.09  E-value: 6.37e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688569121   690 LISNTYSGGKAGEYVTFLTLPLNASQVHVFNTRSIFTHLAVL-LNDKYVVSGNGKPGLSNTYPSPLEKSLiTYKLyltpd 768
Cdd:pfam05986    1 TVSGSFTEGRAKGYVTFVTIPAGATHIHIVNRKPSFTHLAVKnVQGKYILNGKGSISLNPTYPSLLGTVL-EYRR----- 74

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 688569121   769 HLPQTEELYISGPVTDKIHLQVYRKygqeYGDLTNPNISYQYY 811
Cdd:pfam05986   75 SLPALEELHAPGPTQEDLEIQVLRQ----YGKGTNPGITYEYF 113
ADAMTS_CR_3 super family cl41950
ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ...
 574-688 6.33e-34

ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ADAMTS-like endopeptidases widely spread in animals. It is a well-conserved cysteine-rich sequence containing 10 cysteine residues. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase, pfam08516) and consists of at least 20 members sharing a high degree of sequence similarity and conserved domain organization. Members of the ADAMTS family have been implicated in a range of diseases.


The actual alignment was detected with superfamily member pfam19236:

Pssm-ID: 437068  Cd Length: 115  Bit Score: 126.75  E-value: 6.33e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688569121   574 TQLEFMARQCSATDQQPLSVSTDSKSMYTWIPAISYSSGDSQCKLMCRSREQDFMVSRGSQFIDGTRCESDNPVPHGSIS 653
Cdd:pfam19236    1 TQLEFMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQGDALCRHMCRAIGESFIMKRGDSFLDGTRCMPSGPREDGTLS 80

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 688569121   654 ACLSGKCQLFGCDGALHSGKVEDVCGVCGGNGSTC 688
Cdd:pfam19236   81 LCVLGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTC 115
ADAMTS_CR_2 pfam17771
ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS ...
 434-505 4.92e-18

ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS peptidases (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) which is closely related to the ADAM family (pfam08516). Members of the ADAM-TS family have been implicated in a range of diseases. For instance, members of this family have been found to participate directly in processes in the central nervous system (CNS) such as the regulation of brain plasticity.


:

Pssm-ID: 465496  Cd Length: 68  Bit Score: 79.70  E-value: 4.92e-18
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 688569121   434 PGLFYGVDDQCRIAFGSSATACSFTNEDMttCRVLSCHINpqDHSSCTRLLVPLLDGTECGPSQWCLKGRCV 505
Cdd:pfam17771    1 PGQLYSADEQCRLIFGPGSTFCPNGDEDV--CSKLWCSNP--GGSTCTTKNLPAADGTPCGNKKWCLNGKCV 68
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 520-572 1.69e-16

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


:

Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 74.93  E-value: 1.69e-16
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 688569121    520 WSAWSDFSPCSRTCGGGITHRRRQCNNPRSAFGGTICKGQNTEAELCNLQLCD 572
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPCP 53
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1150-1204 3.02e-13

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 65.55  E-value: 3.02e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 688569121  1150 WDVHDWSKCSVSCGYGIQSRAVSCMGPSNPFPLSPFLCLHLPKPITIQACYSPDC 1204
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1090-1146 2.15e-12

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 63.24  E-value: 2.15e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 688569121  1090 WQVGDQGDCSVTCGMGVALRSVQCVQYEGGveRDVEEEKCESETKPPVTVPCFTQVC 1146
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGG--SIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS super family cl40597
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1032-1086 3.46e-09

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


The actual alignment was detected with superfamily member pfam19030:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 54.00  E-value: 3.46e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 688569121  1032 GPCSVSCGGGIAKRVLFCSQRMeendgnNDLVVGETACDSVPKPPEVVECNTEKC 1086
Cdd:pfam19030    7 GECSVTCGGGVQTRLVQCVQKG------GGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS super family cl40597
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 974-1023 3.97e-07

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


The actual alignment was detected with superfamily member pfam19030:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 48.22  E-value: 3.97e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 688569121   974 GECSKTCGNGSQQVQFSCVDHKSRLEVPETLCDPTTKPaQDTQPCRISLC 1023
Cdd:pfam19030    7 GECSVTCGGGVQTRLVQCVQKGGGSIVPDSECSAQKKP-PETQSCNLKPC 55
TSP1_ADAMTS super family cl40597
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 823-879 1.61e-06

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


The actual alignment was detected with superfamily member pfam19030:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 46.68  E-value: 1.61e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 688569121   823 GKWSttisACSVTCGRGIQKIYQHCVDLVTLEHLKDELCSSLPRSSDlLQPCFLPDC 879
Cdd:pfam19030    4 GPWG----ECSVTCGGGVQTRLVQCVQKGGGSIVPDSECSAQKKPPE-TQSCNLKPC 55
TSP1_ADAMTS super family cl40597
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 883-938 1.62e-05

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


The actual alignment was detected with superfamily member pfam19030:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 43.60  E-value: 1.62e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 688569121   883 WQVSEPGECSTVCGPGEAQRKVFCVRFHNKSyLEVDQNLCSQPKPPEYVPCVVDVC 938
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGS-IVPDSECSAQKKPPETQSCNLKPC 55
 
Name Accession Description Interval E-value
ZnMc_ADAMTS_like cd04273
Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) ...
 219-420 3.10e-89

Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that combine ADAM-like metalloproteinases with thrombospondin type-1 repeats. ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) proteinases are inhibited by TIMPs (tissue inhibitors of metalloproteinases), and they play roles in coagulation, angiogenesis, development and progression of arthritis. They hydrolyze the von Willebrand factor precursor and various components of the extracellular matrix.


Pssm-ID: 239801  Cd Length: 207  Bit Score: 288.37  E-value: 3.10e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688569121  219 YLELAVVVGPDVYEV-HRQDTERYILTNLNIASELLRDVTLGANIRVHLVRMIILTEPEPDIQISENITSSLKSVCEWGQ 297
Cdd:cd04273     2 YVETLVVADSKMVEFhHGEDLEHYILTLMNIVASLYKDPSLGNSINIVVVRLIVLEDEESGLLISGNAQKSLKSFCRWQK 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688569121  298 KVNPDADSDPLHADLLLYITRFDLVLPNGNKLVRGVTQFGGVCSTQWNCVITEDTGFDLGITIAHEIGHSFGINHDGIDN 377
Cdd:cd04273    82 KLNPPNDSDPEHHDHAILLTRQDICRSNGNCDTLGLAPVGGMCSPSRSCSINEDTGLSSAFTIAHELGHVLGMPHDGDGN 161

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 688569121  378 TCSSS---GFMMASDGGYNSVDLTWSQCSRAQLYSFFRAGKAECVQ 420
Cdd:cd04273   162 SCGPEgkdGHIMSPTLGANTGPFTWSKCSRRYLTSFLDTGDGNCLL 207
ADAMTS_spacer1 pfam05986
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like ...
 690-811 6.37e-38

ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like proteins. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase) and is a subfamily of the metalloprotease family, sharing a high degree of sequence similarity and conserved domain organization among its members. Members of the ADAM-TS family have been implicated in a range of diseases. ADAM-TS-like proteins lack a metalloprotease domain. They resides in the ECM and have regulatory roles. Examples of ADAM-TS-like proteins are papilin and punctin.


Pssm-ID: 461796  Cd Length: 115  Bit Score: 138.09  E-value: 6.37e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688569121   690 LISNTYSGGKAGEYVTFLTLPLNASQVHVFNTRSIFTHLAVL-LNDKYVVSGNGKPGLSNTYPSPLEKSLiTYKLyltpd 768
Cdd:pfam05986    1 TVSGSFTEGRAKGYVTFVTIPAGATHIHIVNRKPSFTHLAVKnVQGKYILNGKGSISLNPTYPSLLGTVL-EYRR----- 74

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 688569121   769 HLPQTEELYISGPVTDKIHLQVYRKygqeYGDLTNPNISYQYY 811
Cdd:pfam05986   75 SLPALEELHAPGPTQEDLEIQVLRQ----YGKGTNPGITYEYF 113
ADAMTS_CR_3 pfam19236
ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ...
 574-688 6.33e-34

ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ADAMTS-like endopeptidases widely spread in animals. It is a well-conserved cysteine-rich sequence containing 10 cysteine residues. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase, pfam08516) and consists of at least 20 members sharing a high degree of sequence similarity and conserved domain organization. Members of the ADAMTS family have been implicated in a range of diseases.


Pssm-ID: 437068  Cd Length: 115  Bit Score: 126.75  E-value: 6.33e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688569121   574 TQLEFMARQCSATDQQPLSVSTDSKSMYTWIPAISYSSGDSQCKLMCRSREQDFMVSRGSQFIDGTRCESDNPVPHGSIS 653
Cdd:pfam19236    1 TQLEFMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQGDALCRHMCRAIGESFIMKRGDSFLDGTRCMPSGPREDGTLS 80

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 688569121   654 ACLSGKCQLFGCDGALHSGKVEDVCGVCGGNGSTC 688
Cdd:pfam19236   81 LCVLGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTC 115
Reprolysin pfam01421
Reprolysin (M12B) family zinc metalloprotease; The members of this family are enzymes that ...
 219-423 9.72e-21

Reprolysin (M12B) family zinc metalloprotease; The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis. Members of this family are also known as adamalysins. Most members of this family are snake venom endopeptidases, but there are also some mammalian proteins such as Swiss:P78325, and fertilin. Fertilin and closely related proteins appear to not have some active site residues and may not be active enzymes.


Pssm-ID: 426256 [Multi-domain]  Cd Length: 200  Bit Score: 91.98  E-value: 9.72e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688569121   219 YLELAVVVGPDVYEVHRQDTE---RYILTNLNIASELLRDVtlgaNIRVHLVRMIILTEPEPdIQISENITSSLKSVCEW 295
Cdd:pfam01421    2 YIELFIVVDKQLFQKMGSDTTvvrQRVFQVVNLVNSIYKEL----NIRVVLVGLEIWTDEDK-IDVSGDANDTLRNFLKW 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688569121   296 GQKV-NPDADSDplHADLLLYITrfdlvlPNGNKLvrGVTQFGGVCSTQWNCVITEDTGFD---LGITIAHEIGHSFGIN 371
Cdd:pfam01421   77 RQEYlKKRKPHD--VAQLLSGVE------FGGTTV--GAAYVGGMCSLEYSGGVNEDHSKNlesFAVTMAHELGHNLGMQ 146

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 688569121   372 HDGIDN--TCSSSGF--MMASDGGYNSVDltWSQCSRAQLYSFFRAGKAECVQDVP 423
Cdd:pfam01421  147 HDDFNGgcKCPPGGGciMNPSAGSSFPRK--FSNCSQEDFEQFLTKQKGACLFNKP 200
ADAMTS_CR_2 pfam17771
ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS ...
 434-505 4.92e-18

ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS peptidases (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) which is closely related to the ADAM family (pfam08516). Members of the ADAM-TS family have been implicated in a range of diseases. For instance, members of this family have been found to participate directly in processes in the central nervous system (CNS) such as the regulation of brain plasticity.


Pssm-ID: 465496  Cd Length: 68  Bit Score: 79.70  E-value: 4.92e-18
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 688569121   434 PGLFYGVDDQCRIAFGSSATACSFTNEDMttCRVLSCHINpqDHSSCTRLLVPLLDGTECGPSQWCLKGRCV 505
Cdd:pfam17771    1 PGQLYSADEQCRLIFGPGSTFCPNGDEDV--CSKLWCSNP--GGSTCTTKNLPAADGTPCGNKKWCLNGKCV 68
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 520-572 1.69e-16

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 74.93  E-value: 1.69e-16
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 688569121    520 WSAWSDFSPCSRTCGGGITHRRRQCNNPRSAFGGTICKGQNTEAELCNLQLCD 572
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPCP 53
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1150-1204 3.02e-13

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 65.55  E-value: 3.02e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 688569121  1150 WDVHDWSKCSVSCGYGIQSRAVSCMGPSNPFPLSPFLCLHLPKPITIQACYSPDC 1204
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1090-1146 2.15e-12

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 63.24  E-value: 2.15e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 688569121  1090 WQVGDQGDCSVTCGMGVALRSVQCVQYEGGveRDVEEEKCESETKPPVTVPCFTQVC 1146
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGG--SIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1032-1086 3.46e-09

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 54.00  E-value: 3.46e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 688569121  1032 GPCSVSCGGGIAKRVLFCSQRMeendgnNDLVVGETACDSVPKPPEVVECNTEKC 1086
Cdd:pfam19030    7 GECSVTCGGGVQTRLVQCVQKG------GGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP_1 pfam00090
Thrombospondin type 1 domain;
521-571 4.17e-09

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 53.58  E-value: 4.17e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 688569121   521 SAWSDFSPCSRTCGGGITHRRRQCNNPrsAFGGTICKGQNTEAELCNLQLC 571
Cdd:pfam00090    1 SPWSPWSPCSVTCGKGIQVRQRTCKSP--FPGGEPCTGDDIETQACKMDKC 49
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 974-1023 3.97e-07

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 48.22  E-value: 3.97e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 688569121   974 GECSKTCGNGSQQVQFSCVDHKSRLEVPETLCDPTTKPaQDTQPCRISLC 1023
Cdd:pfam19030    7 GECSVTCGGGVQTRLVQCVQKGGGSIVPDSECSAQKKP-PETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 823-879 1.61e-06

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 46.68  E-value: 1.61e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 688569121   823 GKWSttisACSVTCGRGIQKIYQHCVDLVTLEHLKDELCSSLPRSSDlLQPCFLPDC 879
Cdd:pfam19030    4 GPWG----ECSVTCGGGVQTRLVQCVQKGGGSIVPDSECSAQKKPPE-TQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 883-938 1.62e-05

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 43.60  E-value: 1.62e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 688569121   883 WQVSEPGECSTVCGPGEAQRKVFCVRFHNKSyLEVDQNLCSQPKPPEYVPCVVDVC 938
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGS-IVPDSECSAQKKPPETQSCNLKPC 55
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1154-1205 1.40e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 38.34  E-value: 1.40e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 688569121   1154 DWSKCSVSCGYGIQSRAVSCMGPSNPFPLSPflCLHLPKpiTIQACYSPDCS 1205
Cdd:smart00209    6 EWSPCSVTCGGGVQTRTRSCCSPPPQNGGGP--CTGEDV--ETRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 966-1023 8.09e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 36.03  E-value: 8.09e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*...
gi 688569121    966 VYVWSPRTgECSKTCGNGSQQVQFSCVDHKSRleVPETLCDPttkPAQDTQPCRISLC 1023
Cdd:smart00209    1 WSEWSEWS-PCSVTCGGGVQTRTRSCCSPPPQ--NGGGPCTG---EDVETRACNEQPC 52
 
Name Accession Description Interval E-value
ZnMc_ADAMTS_like cd04273
Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) ...
 219-420 3.10e-89

Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that combine ADAM-like metalloproteinases with thrombospondin type-1 repeats. ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) proteinases are inhibited by TIMPs (tissue inhibitors of metalloproteinases), and they play roles in coagulation, angiogenesis, development and progression of arthritis. They hydrolyze the von Willebrand factor precursor and various components of the extracellular matrix.


Pssm-ID: 239801  Cd Length: 207  Bit Score: 288.37  E-value: 3.10e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688569121  219 YLELAVVVGPDVYEV-HRQDTERYILTNLNIASELLRDVTLGANIRVHLVRMIILTEPEPDIQISENITSSLKSVCEWGQ 297
Cdd:cd04273     2 YVETLVVADSKMVEFhHGEDLEHYILTLMNIVASLYKDPSLGNSINIVVVRLIVLEDEESGLLISGNAQKSLKSFCRWQK 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688569121  298 KVNPDADSDPLHADLLLYITRFDLVLPNGNKLVRGVTQFGGVCSTQWNCVITEDTGFDLGITIAHEIGHSFGINHDGIDN 377
Cdd:cd04273    82 KLNPPNDSDPEHHDHAILLTRQDICRSNGNCDTLGLAPVGGMCSPSRSCSINEDTGLSSAFTIAHELGHVLGMPHDGDGN 161

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 688569121  378 TCSSS---GFMMASDGGYNSVDLTWSQCSRAQLYSFFRAGKAECVQ 420
Cdd:cd04273   162 SCGPEgkdGHIMSPTLGANTGPFTWSKCSRRYLTSFLDTGDGNCLL 207
ADAMTS_spacer1 pfam05986
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like ...
 690-811 6.37e-38

ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like proteins. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase) and is a subfamily of the metalloprotease family, sharing a high degree of sequence similarity and conserved domain organization among its members. Members of the ADAM-TS family have been implicated in a range of diseases. ADAM-TS-like proteins lack a metalloprotease domain. They resides in the ECM and have regulatory roles. Examples of ADAM-TS-like proteins are papilin and punctin.


Pssm-ID: 461796  Cd Length: 115  Bit Score: 138.09  E-value: 6.37e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688569121   690 LISNTYSGGKAGEYVTFLTLPLNASQVHVFNTRSIFTHLAVL-LNDKYVVSGNGKPGLSNTYPSPLEKSLiTYKLyltpd 768
Cdd:pfam05986    1 TVSGSFTEGRAKGYVTFVTIPAGATHIHIVNRKPSFTHLAVKnVQGKYILNGKGSISLNPTYPSLLGTVL-EYRR----- 74

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 688569121   769 HLPQTEELYISGPVTDKIHLQVYRKygqeYGDLTNPNISYQYY 811
Cdd:pfam05986   75 SLPALEELHAPGPTQEDLEIQVLRQ----YGKGTNPGITYEYF 113
ADAMTS_CR_3 pfam19236
ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ...
 574-688 6.33e-34

ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ADAMTS-like endopeptidases widely spread in animals. It is a well-conserved cysteine-rich sequence containing 10 cysteine residues. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase, pfam08516) and consists of at least 20 members sharing a high degree of sequence similarity and conserved domain organization. Members of the ADAMTS family have been implicated in a range of diseases.


Pssm-ID: 437068  Cd Length: 115  Bit Score: 126.75  E-value: 6.33e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688569121   574 TQLEFMARQCSATDQQPLSVSTDSKSMYTWIPAISYSSGDSQCKLMCRSREQDFMVSRGSQFIDGTRCESDNPVPHGSIS 653
Cdd:pfam19236    1 TQLEFMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQGDALCRHMCRAIGESFIMKRGDSFLDGTRCMPSGPREDGTLS 80

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 688569121   654 ACLSGKCQLFGCDGALHSGKVEDVCGVCGGNGSTC 688
Cdd:pfam19236   81 LCVLGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTC 115
ZnMc_ADAM_like cd04267
Zinc-dependent metalloprotease, ADAM_like or reprolysin_like subgroup. The adamalysin_like or ...
 219-412 1.40e-27

Zinc-dependent metalloprotease, ADAM_like or reprolysin_like subgroup. The adamalysin_like or ADAM family of metalloproteases contains proteolytic domains from snake venoms, proteases from the mammalian reproductive tract, and the tumor necrosis factor alpha convertase, TACE. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions.


Pssm-ID: 239795  Cd Length: 192  Bit Score: 111.36  E-value: 1.40e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688569121  219 YLELAVVVGPDV---YEVHRQDTERYILTNLNIASELLRDVTLGANIRVHLVRMIILTEPEPDIQISENITSSLKSVCEW 295
Cdd:cd04267     2 EIELVVVADHRMvsyFNSDENILQAYITELINIANSIYRSTNLRLGIRISLEGLQILKGEQFAPPIDSDASNTLNSFSFW 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688569121  296 GQKvnpdadsDPLHADLLLYITRFDLvlpnGNKLVRGVTQFGGVCSTQWNCVITEDTGFDL--GITIAHEIGHSFGINHD 373
Cdd:cd04267    82 RAE-------GPIRHDNAVLLTAQDF----IEGDILGLAYVGSMCNPYSSVGVVEDTGFTLltALTMAHELGHNLGAEHD 150

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 688569121  374 GID----NTCSSSGFMMA-SDGGYNSVDltWSQCSRAQLYSFFR 412
Cdd:cd04267   151 GGDelafECDGGGNYIMApVDSGLNSYR--FSQCSIGSIREFLD 192
ZnMc_adamalysin_II_like cd04269
Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom ...
 219-421 1.08e-24

Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions.


Pssm-ID: 239797 [Multi-domain]  Cd Length: 194  Bit Score: 103.08  E-value: 1.08e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688569121  219 YLELAVVVGPDVYEVHRQD---TERYILTNLNIASELLRDVtlgaNIRVHLVRMIILTEPEPdIQISENITSSLKSVCEW 295
Cdd:cd04269     2 YVELVVVVDNSLYKKYGSNlskVRQRVIEIVNIVDSIYRPL----NIRVVLVGLEIWTDKDK-ISVSGDAGETLNRFLDW 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688569121  296 GQKV-NPDADSDplHADLLLYITrfdlvlPNGNKLvrGVTQFGGVCSTQWNCVITEDTG---FDLGITIAHEIGHSFGIN 371
Cdd:cd04269    77 KRSNlLPRKPHD--NAQLLTGRD------FDGNTV--GLAYVGGMCSPKYSGGVVQDHSrnlLLFAVTMAHELGHNLGME 146

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 688569121  372 HDGIDNTCSSSGFMMASDGGYNSvdLTWSQCSRAQLYSFFRAGKAECVQD 421
Cdd:cd04269   147 HDDGGCTCGRSTCIMAPSPSSLT--DAFSNCSYEDYQKFLSRGGGQCLLN 194
Reprolysin pfam01421
Reprolysin (M12B) family zinc metalloprotease; The members of this family are enzymes that ...
 219-423 9.72e-21

Reprolysin (M12B) family zinc metalloprotease; The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis. Members of this family are also known as adamalysins. Most members of this family are snake venom endopeptidases, but there are also some mammalian proteins such as Swiss:P78325, and fertilin. Fertilin and closely related proteins appear to not have some active site residues and may not be active enzymes.


Pssm-ID: 426256 [Multi-domain]  Cd Length: 200  Bit Score: 91.98  E-value: 9.72e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688569121   219 YLELAVVVGPDVYEVHRQDTE---RYILTNLNIASELLRDVtlgaNIRVHLVRMIILTEPEPdIQISENITSSLKSVCEW 295
Cdd:pfam01421    2 YIELFIVVDKQLFQKMGSDTTvvrQRVFQVVNLVNSIYKEL----NIRVVLVGLEIWTDEDK-IDVSGDANDTLRNFLKW 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688569121   296 GQKV-NPDADSDplHADLLLYITrfdlvlPNGNKLvrGVTQFGGVCSTQWNCVITEDTGFD---LGITIAHEIGHSFGIN 371
Cdd:pfam01421   77 RQEYlKKRKPHD--VAQLLSGVE------FGGTTV--GAAYVGGMCSLEYSGGVNEDHSKNlesFAVTMAHELGHNLGMQ 146

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 688569121   372 HDGIDN--TCSSSGF--MMASDGGYNSVDltWSQCSRAQLYSFFRAGKAECVQDVP 423
Cdd:pfam01421  147 HDDFNGgcKCPPGGGciMNPSAGSSFPRK--FSNCSQEDFEQFLTKQKGACLFNKP 200
ADAMTS_CR_2 pfam17771
ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS ...
 434-505 4.92e-18

ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS peptidases (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) which is closely related to the ADAM family (pfam08516). Members of the ADAM-TS family have been implicated in a range of diseases. For instance, members of this family have been found to participate directly in processes in the central nervous system (CNS) such as the regulation of brain plasticity.


Pssm-ID: 465496  Cd Length: 68  Bit Score: 79.70  E-value: 4.92e-18
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 688569121   434 PGLFYGVDDQCRIAFGSSATACSFTNEDMttCRVLSCHINpqDHSSCTRLLVPLLDGTECGPSQWCLKGRCV 505
Cdd:pfam17771    1 PGQLYSADEQCRLIFGPGSTFCPNGDEDV--CSKLWCSNP--GGSTCTTKNLPAADGTPCGNKKWCLNGKCV 68
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 520-572 1.69e-16

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 74.93  E-value: 1.69e-16
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 688569121    520 WSAWSDFSPCSRTCGGGITHRRRQCNNPRSAFGGTICKGQNTEAELCNLQLCD 572
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPCP 53
ZnMc_salivary_gland_MPs cd04272
Zinc-dependent metalloprotease, salivary_gland_MPs. Metalloproteases secreted by the salivary ...
 219-420 4.04e-15

Zinc-dependent metalloprotease, salivary_gland_MPs. Metalloproteases secreted by the salivary glands of arthropods.


Pssm-ID: 239800  Cd Length: 220  Bit Score: 76.24  E-value: 4.04e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688569121  219 YLELAVVVGPDVYEvHRQDTE---RYILTNLNIASELLRDVTlGANIRVHLVRMIILTEPEPDIQI----SENI--TSSL 289
Cdd:cd04272     2 YPELFVVVDYDHQS-EFFSNEqliRYLAVMVNAANLRYRDLK-SPRIRLLLVGITISKDPDFEPYIhpinYGYIdaAETL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688569121  290 KSVCEWGQKvnpdaDSDPLHADLLLYITRFDLVLPNGNKL---VRGVTQFGGVCsTQWNCVITEDT-GFDLGI-TIAHEI 364
Cdd:cd04272    80 ENFNEYVKK-----KRDYFNPDVVFLVTGLDMSTYSGGSLqtgTGGYAYVGGAC-TENRVAMGEDTpGSYYGVyTMTHEL 153

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 688569121  365 GHSFGINHDGIDNT-----------CS-SSGFMMA-SDGGYNSvdLTWSQCSRAQLYSFFRAGKAECVQ 420
Cdd:cd04272   154 AHLLGAPHDGSPPPswvkghpgsldCPwDDGYIMSyVVNGERQ--YRFSQCSQRQIRNVFRRLGASCLH 220
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1150-1204 3.02e-13

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 65.55  E-value: 3.02e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 688569121  1150 WDVHDWSKCSVSCGYGIQSRAVSCMGPSNPFPLSPFLCLHLPKPITIQACYSPDC 1204
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1090-1146 2.15e-12

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 63.24  E-value: 2.15e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 688569121  1090 WQVGDQGDCSVTCGMGVALRSVQCVQYEGGveRDVEEEKCESETKPPVTVPCFTQVC 1146
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGG--SIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1032-1086 3.46e-09

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 54.00  E-value: 3.46e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 688569121  1032 GPCSVSCGGGIAKRVLFCSQRMeendgnNDLVVGETACDSVPKPPEVVECNTEKC 1086
Cdd:pfam19030    7 GECSVTCGGGVQTRLVQCVQKG------GGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP_1 pfam00090
Thrombospondin type 1 domain;
521-571 4.17e-09

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 53.58  E-value: 4.17e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 688569121   521 SAWSDFSPCSRTCGGGITHRRRQCNNPrsAFGGTICKGQNTEAELCNLQLC 571
Cdd:pfam00090    1 SPWSPWSPCSVTCGKGIQVRQRTCKSP--FPGGEPCTGDDIETQACKMDKC 49
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 974-1023 3.97e-07

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 48.22  E-value: 3.97e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 688569121   974 GECSKTCGNGSQQVQFSCVDHKSRLEVPETLCDPTTKPaQDTQPCRISLC 1023
Cdd:pfam19030    7 GECSVTCGGGVQTRLVQCVQKGGGSIVPDSECSAQKKP-PETQSCNLKPC 55
Reprolysin_4 pfam13583
Metallo-peptidase family M12B Reprolysin-like; This zinc-binding metallo-peptidase has the ...
 222-383 1.56e-06

Metallo-peptidase family M12B Reprolysin-like; This zinc-binding metallo-peptidase has the characteriztic binding motif HExxGHxxGxxH of Reprolysin-like peptidases of family M12B.


Pssm-ID: 404471  Cd Length: 203  Bit Score: 50.70  E-value: 1.56e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688569121   222 LAVVVGPDVYEVHRQDTE--RYILTNLNIASELLRDvTLGANIRVHLVRMIILTEPEPDIQISENITSSLKSvceWGQkV 299
Cdd:pfam13583    7 VAVATDCTYSASFGSVDElrANINATVTTANEVYGR-DFNVSLALISDRDVIYTDSSTDSFNADCSGGDLGN---WRL-A 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688569121   300 NPDADSDPLHADLLLYITRFDlvlPNGNKLvrGVTQFGGVCST-----QWNCVITEDTGFDlgiTIAHEIGHSFGINHDg 374
Cdd:pfam13583   82 TLTSWRDSLNYDLAYLTLMTG---PSGQNV--GVAWVGALCSSarqnaKASGVARSRDEWD---IFAHEIGHTFGAVHD- 152


                   ....*....
gi 688569121   375 idntCSSSG 383
Cdd:pfam13583  153 ----CSSQG 157
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 823-879 1.61e-06

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 46.68  E-value: 1.61e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 688569121   823 GKWSttisACSVTCGRGIQKIYQHCVDLVTLEHLKDELCSSLPRSSDlLQPCFLPDC 879
Cdd:pfam19030    4 GPWG----ECSVTCGGGVQTRLVQCVQKGGGSIVPDSECSAQKKPPE-TQSCNLKPC 55
ZnMc cd00203
Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major ...
 277-410 4.04e-06

Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which are involved in vertebrate development and disease.


Pssm-ID: 238124 [Multi-domain]  Cd Length: 167  Bit Score: 48.67  E-value: 4.04e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688569121  277 PDIQISENITSSLKSvceWGQKVN---PDADSDPLHADLLLYITRFDLVLPNGnklvrGVTQFGGVCSTQWNCVITEDTG 353
Cdd:cd00203    19 LSAQIQSLILIAMQI---WRDYLNirfVLVGVEIDKADIAILVTRQDFDGGTG-----GWAYLGRVCDSLRGVGVLQDNQ 90

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 688569121  354 FD---LGITIAHEIGHSFGINHDGIDNTCSSSGFMMAS----DGGYNSV------------DLTWSQCSRAQLYSF 410
Cdd:cd00203    91 SGtkeGAQTIAHELGHALGFYHDHDRKDRDDYPTIDDTlnaeDDDYYSVmsytkgsfsdgqRKDFSQCDIDQINKL 166
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 883-938 1.62e-05

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 43.60  E-value: 1.62e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 688569121   883 WQVSEPGECSTVCGPGEAQRKVFCVRFHNKSyLEVDQNLCSQPKPPEYVPCVVDVC 938
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGS-IVPDSECSAQKKPPETQSCNLKPC 55
Reprolysin_3 pfam13582
Metallo-peptidase family M12B Reprolysin-like; This zinc-binding metallo-peptidase has the ...
 261-373 1.69e-05

Metallo-peptidase family M12B Reprolysin-like; This zinc-binding metallo-peptidase has the characteriztic binding motif HExxGHxxGxxH of Reprolysin-like peptidases of family M12B.


Pssm-ID: 463926 [Multi-domain]  Cd Length: 122  Bit Score: 45.82  E-value: 1.69e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688569121   261 NIRVHLVRMIILTEPEpDIQISENITSSLKSVCEWGQKVNPDADSDPLHadlllyitrfdLVLPNGNKLVRGVTQFGGVC 340
Cdd:pfam13582   19 GIRLQLAAIIITTSAD-TPYTSSDALEILDELQEVNDTRIGQYGYDLGH-----------LFTGRDGGGGGGIAYVGGVC 86

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 688569121   341 STQWNCVITEDTG--FDLG-ITIAHEIGHSFGINHD 373
Cdd:pfam13582   87 NSGSKFGVNSGSGpvGDTGaDTFAHEIGHNFGLNHT 122
Reprolysin_5 pfam13688
Metallo-peptidase family M12;
222-396 3.23e-05

Metallo-peptidase family M12;


Pssm-ID: 372673  Cd Length: 191  Bit Score: 46.26  E-value: 3.23e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688569121   222 LAVVVGPDVYEVHRQD-TERYILTNLNIASELL-RDVtlgaNIRVHLVRMIILTEPEPDIQI------SENITSSLKSVC 293
Cdd:pfam13688    7 LLVAADCSYVAAFGGDaAQANIINMVNTASNVYeRDF----NISLGLVNLTISDSTCPYTPPacstgdSSDRLSEFQDFS 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688569121   294 EWGQKvnpdadsdplHADLLLYITRfDLVLPNGnklvrGVTQFGGVC--STQWNC---------VITEDTGFdlgITIAH 362
Cdd:pfam13688   83 AWRGT----------QNDDLAYLFL-MTNCSGG-----GLAWLGQLCnsGSAGSVstrvsgnnvVVSTATEW---QVFAH 143

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*.
gi 688569121   363 EIGHSFGINHD-----------GIDNTCSSSG-FMMASDGGYNSVD 396
Cdd:pfam13688  144 EIGHNFGAVHDcdsstssqccpPSNSTCPAGGrYIMNPSSSPNSTD 189
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 521-571 7.39e-05

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 41.88  E-value: 7.39e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 688569121   521 SAWSDFSPCSRTCGGGITHRRRQCNNPrSAFGGTICkGQNTEAELCNLQLC 571
Cdd:pfam19028    4 SEWSEWSECSVTCGGGVQTRTRTVIVE-PQNGGRPC-PELLERRPCNLPPC 52
Reprolysin_2 pfam13574
Metallo-peptidase family M12B Reprolysin-like; This zinc-binding metallo-peptidase has the ...
 332-407 1.78e-04

Metallo-peptidase family M12B Reprolysin-like; This zinc-binding metallo-peptidase has the characteriztic binding motif HExxGHxxGxxH of Reprolysin-like peptidases of family M12B.


Pssm-ID: 372637  Cd Length: 193  Bit Score: 44.16  E-value: 1.78e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688569121   332 GVTQFGGVCSTQWNCVITeDTGFDLGIT-------------IAHEIGHSFGINHD--------------GIDNTCSSSG- 383
Cdd:pfam13574   88 GLAYVGQICQKGASSPKT-NTGLSTTTNygsfnyptqewdvVAHEVGHNFGATHDcdgsqyassgcernAATSVCSANGs 166

                           90       100
                   ....*....|....*....|....
gi 688569121   384 FMMASDGGYNSVDltWSQCSRAQL 407
Cdd:pfam13574  167 FIMNPASKSNNDL--FSPCSISLI 188
ZnMc_TACE_like cd04270
Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha ...
 358-420 6.47e-04

Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha converting enzyme, releases soluble TNF-alpha from transmembrane pro-TNF-alpha.


Pssm-ID: 239798 [Multi-domain]  Cd Length: 244  Bit Score: 43.13  E-value: 6.47e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688569121  358 ITIAHEIGHSFGINHDGIDNTCSSSG-----FMM--ASDGGYNSVDLTWSQCSRAQLYSFFRAGKAECVQ 420
Cdd:cd04270   169 LVTAHELGHNFGSPHDPDIAECAPGEsqggnYIMyaRATSGDKENNKKFSPCSKKSISKVLEVKSNSCFV 238
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 520-571 7.95e-04

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 38.97  E-value: 7.95e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 688569121   520 WSAwSDFSPCSRTCGGGITHRRRQCnnpRSAFGGTICKGQN-------TEAELCNLQLC 571
Cdd:pfam19030    1 WVA-GPWGECSVTCGGGVQTRLVQC---VQKGGGSIVPDSEcsaqkkpPETQSCNLKPC 55
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1154-1205 1.40e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 38.34  E-value: 1.40e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 688569121   1154 DWSKCSVSCGYGIQSRAVSCMGPSNPFPLSPflCLHLPKpiTIQACYSPDCS 1205
Cdd:smart00209    6 EWSPCSVTCGGGVQTRTRSCCSPPPQNGGGP--CTGEDV--ETRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 966-1023 8.09e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 36.03  E-value: 8.09e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*...
gi 688569121    966 VYVWSPRTgECSKTCGNGSQQVQFSCVDHKSRleVPETLCDPttkPAQDTQPCRISLC 1023
Cdd:smart00209    1 WSEWSEWS-PCSVTCGGGVQTRTRSCCSPPPQ--NGGGPCTG---EDVETRACNEQPC 52
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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