GEO DataSet Links for SRA (Select 958142) - GEO DataSets

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Items: 2

Select item 3014829071.

siNELF replicat2

Organism:: Homo sapiens

Source name:: siNELF

Platform:: GPL11154
Series:: GSE60585 GSE60586

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Accession:: GSM1482907

ID:: 301482907

SRA Run Selector

Select item 2000605852.

Integrator complex regulates NELF-mediated RNA Polymerase II pause/release and processivity at coding genes [RNA-seq]

(Submitter supplied) RNAPII pausing/termination shortly after initiation is a hallmark of gene regulation. However, the molecular mechanisms involved are still to be uncovered. Here, we show that NELF interacts with Integrator complex subunits (INTScom) forming a stable complex with RNPII and Spt5. The interaction between NELF and INTScom subunits is RNA and DNA independent. Using both HIV-1 promoter and genome wide analyses, we demonstrate that Integrator subunits specifically control NELF-mediated RNAPII pause/release at coding genes. more...