GEO DataSet Links for SRA (Select 3182352) - GEO DataSets

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Items: 2

Select item 3023268671.

sKH1_siREVI1-D4-Replicate1

Organism:: Homo sapiens

Source name:: RUNX1-EVI1 KD SKH-1 cells 4 days rep1

Platform:: GPL16791
Series:: GSE87285 GSE87286

Download data: BW

Sample

Accession:: GSM2326867

ID:: 302326867

SRA Run Selector

Select item 2000872852.

RUNX1-ETO and RUNX1-EVI-1 differentially program the chromatin landscape in t(3;21) and t(8;21) AML but share global C/EBP-alpha dysfunction (RNA-Seq)

(Submitter supplied) RUNX1 is a frequent target of translocations in acute myeloid leukemia whereby its DNA binding domain fuses to different epigenetic regulators. To assess how different RUNX1 fusion proteins interact with the epigenome we compared the global binding patterns and the chromatin landscape of t(8;21) and t(3;21) AML which express RUNX1-ETO and RUNX1-EVI-1, respectively. We found that differential prognosis for these types of AML is reflected in fundamental differences in gene expression, chromatin landscape, binding patterns of the fusion proteins and other transcription factors as identified by genome-wide digital footprinting in patients. more...