Tumor-specific retargeting of an oncogenic transcription factor chimera results in dysregulation of chromatin and transcription - - GEO DataSets

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Tumor-specific retargeting of an oncogenic transcription factor chimera results in dysregulation of chromatin and transcription

(Submitter supplied) Using EWS-FLI and its parental transcription factor, FLI1, we created a unique experimental system to address questions regarding the genomic mechanisms by which chimeric transcription factors cause cancer. We found that in tumor cells, EWS-FLI targets regions of the genome distinct from FLI1, despite identical DNA-binding domains. In primary endothelial cells, however, EWS-FLI and FLI1 demonstrate similar targeting. more...

Organism:: Homo sapiens

Type:: Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL5188 GPL10999
32 Samples

Download data: BED, CEL

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Accession:: GSE31838

ID:: 200031838

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