GEO DataSet Links for PMC (Select 10781626) - GEO DataSets

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Items: 3

Select item 2002228351.

In vitro production of cat-restricted Toxoplasma pre-sexual stages by epigenetic reprogramming

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Toxoplasma gondii

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL23466 GPL26742
24 Samples

Download data: BW

Series

Accession:: GSE222835

ID:: 200222835

PubMed Full text in PMC Similar studies

Select item 2002228322.

In vitro production of cat-restricted Toxoplasma pre-sexual stages by epigenetic reprogramming [ATAC-seq]

(Submitter supplied) Here we show that AP2XII-1 and AP2XI-2, two transcription factors expressed in tachyzoites, a stage that causes acute toxoplasmosis, silence genes specific to merozoites, a developmental stage critical for sexual commitment and transmission to the next host, including humans. Their conditional and simultaneous depletion leads to a drastic change in the transcriptional program, promoting a complete transition from tachyzoites to merozoites. more...