GEO DataSets

Analysis of heart left ventricles from animals subjected to 7 weeks treadmill exercise compared with sedentary controls. Provides insight into molecular mechanisms of left ventricular hypertrophy.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 protocol sets

Platform:

GPL85

Series:

GSE739

12 Samples

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(Submitter supplied) Cardiac hypertrophy was induced by treadmill running. Sedentary animals served as controls. Gene expression was determined by Affymetrix RGU34A GeneChip's to identify genes with differential expression in an adaptive model of cardiac hypertrophy. Keywords: other

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS654

Platform:

GPL85

12 Samples

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(Submitter supplied) We recently introduced a modification of the established monocrotaline (MCT) model for pulmonary hypertension (PH) and subsequent right ventricular (RV) hypertrophy, which allows for the selective induction of either a compensate or decompensated RV hypertrophic phenotype within four weeks after a single subcutaneous MCT injection. Both doses of 30 or 80 mg/kg body weight lead to an intermediate phase of compensated RV hypertrophy (day 14-19), while the former dose leads to a stable compensated phenotype (HYP) and the latter dose progresses towards decompensated ventricular hypertrophy and RV failure (CHF) around day 25-28 (Buermans et. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS1928

Platform:

GPL1397

27 Samples

Download data: IMAGENE

(Submitter supplied) 14 days after a single subcutaneous monocrotaline (MCT) injection we isolated the left and right ventricles from wistar rats. Factor1: Comparison between control (CON), compensated hypertrophy (HYP), and decompensated hypertrophy (CHF). Factor2: Comparison between left ventricle (LV) and right ventricle (RV). Keywords: dose response

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS742

Platform:

GPL1397

24 Samples

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Temporal analysis of right ventricles at the onset of compensated or decompensated right ventricular hypertrophy. Compensated and decompensated phenotypes induced by injection with 30 and 80 mg/kg monocrotaline, respectively. Results identify potential prognostic markers and therapeutic targets.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, log2 ratio, 3 disease state, 3 time sets

Platform:

GPL1397

Series:

GSE3675

27 Samples

Download data: IMAGENE

Analysis of compensated and decompensated hypertrophies induced by monocrotaline in Wistar. Left and right heart ventricles examined 14 days after monocrotaline injection. Decompensated hypertrophy is a prelude to chronic heart failure.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, log ratio, 3 disease state, 2 tissue sets

Platform:

GPL1397

Series:

GSE1652

24 Samples

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(Submitter supplied) Aerobic capacity is a strong predictor of cardiovascular mortality. To determine the relationship between aerobic capacity and cardiac gene expression we examined genome-wide gene expression in hearts of rats artificially selected for high- and low running capacity (HCR and LCR, respectively) over 16 generations. HCR were born with an athletic phenotype, whereas LCR exhibited features of the metabolic syndrome. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS3131

Platform:

GPL1355

16 Samples

Download data: CEL

Analysis of hearts from low (LCRs) and high capacity runners (HCRs) with or without exercise training. Aerobic capacity is a strong predictor of cardiovascular mortality. Results provide insight into the molecular basis for the difference in inborn aerobic capacity in the LCRs and HCRs.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, transformed count, 2 protocol, 2 strain sets

Platform:

GPL1355

Series:

GSE9445

16 Samples

Download data: CEL

(Submitter supplied) We used high density oligonucleotide arrays to measure the relative expression levels of ~27,000 probe sets in the left ventricles of inbred rat strains; DA (high performing), Copenhagen (COP, low performing), as well as F1(COPxDA) rats bred from these two strains whose performance was intermediate relative to both parental strains. DA and COP rats differ for both intrinsic aerobic running capacity (assessed with a treadmill exercise test to exhaustion) and intrinsic cardiac performance (as assessed by the Langendorff-Neeley working heart model). more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Datasets:

GDS778 GDS779 GDS780

Platforms:

GPL87 GPL86 GPL85

36 Samples

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Expression profiling of heart left ventricles from 15 week old inbred COP, DA, and COP x DA F1 offspring (low, high, and intermediate performers respectively). Results provide insight into mechanisms underlying aerobic capacity.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 3 strain sets

Platform:

GPL87

Series:

GSE1795

12 Samples

Download data

Expression profiling of heart left ventricles from 15 week old inbred COP, DA, and COP x DA F1 offspring (low, high, and intermediate performers respectively). Results provide insight into mechanisms underlying aerobic capacity.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 3 strain sets

Platform:

GPL86

Series:

GSE1795

12 Samples

Download data

Expression profiling of heart left ventricles from 15 week old inbred COP, DA, and COP x DA F1 offspring (low, high, and intermediate performers respectively). Results provide insight into mechanisms underlying aerobic capacity.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 3 strain sets

Platform:

GPL85

Series:

GSE1795

12 Samples

Download data

(Submitter supplied) The project had 2 goals: 1) To evaluate the transcriptional response of 3 prototypical toxicants (Clofibrate, VPA, and DEHP) on rat lever. 2) To evaluate the impact pooling samples has on data analysis. Keywords = Clofibrate Keywords = Diethylhexyl phthalate Keywords = Phthalic acid bis(2-ethylhexyl ester) Keywords = Sodium Valproate Keywords = Valproic Acid Keywords = VPA Keywords = vehicle Keywords: other

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS1451

Platform:

GPL85

94 Samples

Download data: CEL, CHP, EXP

Analysis of livers of Sprague-Dawley males at various time points up to 168 hours after treatment with clofibrate, diethylhexylphthalate, or valproic acid. Expression profiles from pooled and individual samples compared. Results provide insight into the impact of pooling on experimental analysis.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 3 agent, 2 protocol, 4 time sets

Platform:

GPL85

Series:

GSE2303

94 Samples

Download data: CEL, CHP, EXP

(Submitter supplied) Rats underwent surgery for LAD ligation for 30 min followed by reperfusion. Heart ventricles were collected 2d or 7d after reperfusion. Keywords: rat heart ventricles, LAD - left anterior descending coronary artery, IR - ischemia-reperfusion

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS1959

Platform:

GPL341

12 Samples

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Analysis of ischemic heart ventricles 2 or 7 days after reperfusion. Ischemia induced by occlusion of the left anterior descending coronary artery. Results provide insight into the molecular mechanisms involved in the early and late inflammatory phases of acute myocardial infarction.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 protocol, 2 time sets

Platform:

GPL341

Series:

GSE4105

12 Samples

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(Submitter supplied) d-serine is naturally present throughout the human body. It is also used as add-on therapy for treatment-refractory schizophrenia. d-Serine interacts with the strychnine-insensitive glycine binding site of NMDA receptor, and this interaction could lead to potentially toxic activity (i.e., excitotoxicity) in brain tissue. The transcriptomic changes that occur in the brain after d-serine exposure have not been fully explored. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS3643

Platform:

GPL1355

24 Samples

Download data: CEL

Analysis of forebrains of animals treated with up to 500 mg/kg D-serine for 96 hours. D-serine is involved in many physiological processes through its interaction with the glycine binding site of the NMDA receptor. Results provide insight into the impact of D-serine exposure on neuronal functions.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 agent, 6 dose sets

Platform:

GPL1355

Series:

GSE10748

24 Samples

Download data: CEL

(Submitter supplied) we analyzed the gene expression profiles of Mat-Lylu cell lines (in duplicate) compared to G cell lines (in duplicate) using Affymetrix tools and dChip software. The objective was to find metastasis-associated genes in prostate cancer, using this in vitro model. Keywords: cell line comparison

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL85

4 Samples

Download data: CEL

(Submitter supplied) Time and dose related expression profiles of rat right heart tissue in microsphere bead model for Pulmonary embolism Keywords: Time course and dose response in experimental PE

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS3414

Platform:

GPL1355

45 Samples

Download data: CEL