Similar studies for GEO DataSets (Select 4567) - GEO DataSets

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Items: 3

Select item 45671.

Filarial nematode asparaginyl-tRNA synthetase effect on immature dendritic cells

Analysis of iDCs stimulated with rBmAsnRS, a recombinant nematode protein. Dysregulation of DCs has been implicated in human inflammatory bowel disease (IBD) pathogenesis. rBmAsnRS attenuates colonic inflammation in a murine model of IBD. Results provide insight into the molecular basis of IBD.

Organism:: Homo sapiens

Type:: Expression profiling by array, transformed count, 3 protocol sets

Platform:: GPL570
Series:: GSE39999
6 Samples

Download data: CEL

DataSet

Accession:: GDS4567

ID:: 4567

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2000399992.

Filarial nematode AsnRS interacts with interleukin 8 receptors in iDCs but causes different gene expression patterns compared to iDCs stimulated by interleukin 8.

(Submitter supplied) Nematode derived substances are known to down regulate host immune responses in order to survive in the human host. Brugia malayi is a parasitic nematode responsible for long lasting and disabling infection known as lymphatic filariasis in humans. The therapeutic benefit of a controlled parasitic nematode infection on the course of inflammatory bowel disease (IBD) has been demonstrated in both animal and human models. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS4567
Platform:: GPL570
6 Samples

Download data: CEL

Series

Accession:: GSE39999

ID:: 200039999

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000614603.

Splenic B cells from Hymenolepis diminuta-infected mice ameliorate colitis independent of T cells and via cooperation with macrophages

(Submitter supplied) Mouse infection with the tapeworm Hymenolepis diminuta leads to a less severe DNBS-colitis. Increased Th2 and regulatory cytokine production in the spleen is a hallmark of Hymenolepis diminuta infection, therefore we hypothesized that given this microenvironment, splenic adaptive cells acquire an anti-inflammatory phenotype. We tested the ability of putative splenic regulatory B cells generated by Hymenolepis diminuta infection to down-regulate intestinal inflammation. more...