Similar studies for GEO DataSets (Select 2602) - GEO DataSets

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Items: 2

Select item 26021.

COX-1 or COX-2 knockout effect in brain

Analysis of cortex and hippocampus in cyclooxygenase (COX)-1 and COX-2 knockouts. COX-1 and COX-2 produce prostanoids from arachidonic acid. Results indicate COX-1 and COX-2 differentially modulate brain gene expression, and give insight into therapeutic and toxicologic effects of COX inhibition.

Organism:: Mus musculus

Type:: Expression profiling by array, Z-score, 5 strain, 2 tissue sets

Platform:: GPL4006
Series:: GSE5342
30 Samples

Download data: GEL

DataSet

Accession:: GDS2602

ID:: 2602

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2000053422.

Expression data from Cerebral Cortex or Hippocampus of COX-1 or COX-2 null mice

(Submitter supplied) To further understand the physiological role of cyclooxygenase (COX), the critical enzyme involved in the production of eicosanoids from arachidonic acid, we performed microarray analysis of gene expression in the cerebral cortex and hippocampus of mice deficient in COX-1 (COX-1-/-) or COX-2 (COX-2-/-). Expression of lipid (ATP citrate lyase, acetyl-CoA acetyltransferase, hydroxyacyl-CoA dehydrogenase) and homocysteine (methionine adenosyltransferase, S-adenosylhomocysteine hydrolase) metabolism genes was increased in the cerebral cortex of COX-2 -/- mice. more...