GEO DataSets

Analysis of heart left ventricles (LVs) of animals with pressure overload LV hypertrophy (LVH) caused by transverse aortic constriction. Pressure overload on the heart resulting from chronic hypertension or aortic stenosis is a stimulus for LVH. Results provide insight into the pathogenesis of LVH.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 disease state, 2 gender sets

Platform:

GPL81

Series:

GSE2459

15 Samples

Download data

(Submitter supplied) Expression profiling of hearts from FVB males subjected to cardiac pressure overload by transverse aortic constriction (TAC). TAC performed on 8-10 weeks month old males and females. Hearts examined 30 weeks after surgery. Keywords: ordered

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS2258

Platform:

GPL81

15 Samples

Download data

(Submitter supplied) Myoglobin knockout mice (myo-/-) adapt to the loss of myoglobin by the activation of a variety of compensatory mechanisms on the structural and functional level. In order to analyze to what extent myo-/- mice would tolerate cardiac stress we used the model of chronic isoproterenol application to induce cardiac hypertrophy in myo-/- mice and wild type (WT) controls. After 14 d of isoproterenol infusion cardiac hypertrophy in WT and myo-/- mice reached a similar level. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL8600

16 Samples

Download data: GPR

(Submitter supplied) Myoglobin knockout mice (myo-/-) adapt to the loss of myoglobin by the activation of a variety of compensatory mechanisms on the structural and functional level. In order to analyze to what extent myo-/- mice would tolerate cardiac stress we used the model of chronic isoproterenol application to induce cardiac hypertrophy in myo-/- mice and wild type (WT) controls. After 14 d of isoproterenol infusion cardiac hypertrophy in WT and myo-/- mice reached a similar level. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL8599

16 Samples

Download data: GPR

(Submitter supplied) Cardiac hypertrophy was induced by treadmill running. Sedentary animals served as controls. Gene expression was determined by Affymetrix RGU34A GeneChip's to identify genes with differential expression in an adaptive model of cardiac hypertrophy. Keywords: other

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS654

Platform:

GPL85

12 Samples

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Analysis of heart left ventricles from animals subjected to 7 weeks treadmill exercise compared with sedentary controls. Provides insight into molecular mechanisms of left ventricular hypertrophy.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 protocol sets

Platform:

GPL85

Series:

GSE739

12 Samples

Download data

(Submitter supplied) Left ventricular gene expression profiles from 12-, 16- and 20-months old spontaneously hypertensive rats (SHRs) were compared with left ventricular profiles seen in age-matched Wistar-Kyoto (WKY) rats by screening Affymetrix U34A arrays (there are 4 samples in each timepoint except 3 samples of 20-months old WKYs). Keywords: time-course

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS1264

Platform:

GPL85

23 Samples

Download data: CEL, EXP

Analysis of progressive left ventricular hypertrophy (LVH) in spontaneously hypertensive (SHR) males at 12, 16, and 20 months of age. LVH impairs diastolic relaxation, which decreases cardiac output and leads to heart failure (HF). Provides insight into pathogenesis of hypertrophy and LV remodeling.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 3 age, 2 strain sets

Platform:

GPL85

Series:

GSE2116

23 Samples

Download data: CEL, EXP

(Submitter supplied) We recently introduced a modification of the established monocrotaline (MCT) model for pulmonary hypertension (PH) and subsequent right ventricular (RV) hypertrophy, which allows for the selective induction of either a compensate or decompensated RV hypertrophic phenotype within four weeks after a single subcutaneous MCT injection. Both doses of 30 or 80 mg/kg body weight lead to an intermediate phase of compensated RV hypertrophy (day 14-19), while the former dose leads to a stable compensated phenotype (HYP) and the latter dose progresses towards decompensated ventricular hypertrophy and RV failure (CHF) around day 25-28 (Buermans et. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS1928

Platform:

GPL1397

27 Samples

Download data: IMAGENE

(Submitter supplied) 14 days after a single subcutaneous monocrotaline (MCT) injection we isolated the left and right ventricles from wistar rats. Factor1: Comparison between control (CON), compensated hypertrophy (HYP), and decompensated hypertrophy (CHF). Factor2: Comparison between left ventricle (LV) and right ventricle (RV). Keywords: dose response

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS742

Platform:

GPL1397

24 Samples

Download data

Temporal analysis of right ventricles at the onset of compensated or decompensated right ventricular hypertrophy. Compensated and decompensated phenotypes induced by injection with 30 and 80 mg/kg monocrotaline, respectively. Results identify potential prognostic markers and therapeutic targets.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, log2 ratio, 3 disease state, 3 time sets

Platform:

GPL1397

Series:

GSE3675

27 Samples

Download data: IMAGENE

Analysis of compensated and decompensated hypertrophies induced by monocrotaline in Wistar. Left and right heart ventricles examined 14 days after monocrotaline injection. Decompensated hypertrophy is a prelude to chronic heart failure.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, log ratio, 3 disease state, 2 tissue sets

Platform:

GPL1397

Series:

GSE1652

24 Samples

Download data

(Submitter supplied) We employed the Affymetrix GeneChip technology to evaluate the patterns of expression in two different in vivo models of cardiac remodeling and in two different regions (left ventricle free wall and septum) of the heart. Mice underwent transverse aortic constriction (TAC); myocardial infarction (MI) or Sham operation and RNA from the left ventricle free wall and the septum was isolated 1 week later. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Datasets:

GDS387 GDS388

Platforms:

GPL75 GPL76

36 Samples

Download data

Evaluation of in vivo models of cardiac remodeling. Mice underwent transverse aortic constriction (TAC); myocardial infarction (MI) or sham operation. Left ventricle free wall and septum tissues examined 1 week later.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 3 protocol, 2 tissue sets

Platform:

GPL76

Series:

GSE415

18 Samples

Download data

Evaluation of in vivo models of cardiac remodeling. Mice underwent transverse aortic constriction (TAC); myocardial infarction (MI) or sham operation. Left ventricle free wall and septum tissues examined 1 week later.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 3 protocol, 2 tissue sets

Platform:

GPL75

Series:

GSE415

18 Samples

Download data

(Submitter supplied) BACKGROUND - MicroRNAs (miRs) are a class of small non-coding RNAs that regulate gene expression. Transgenic models have proved that a single miR can induce pathological cardiac hypertrophy and failure. The roles of miRs in the genesis of physiologic left ventricular hypertrophy (LVH), however, are not well elucidated. OBJECTIVE - To evaluate miRs expression in an experimental model of exercise-induced LVH. more...

Organism:

Mus musculus

Type:

Non-coding RNA profiling by array

Platform:

GPL17419

4 Samples

Download data: TXT

(Submitter supplied) Adenosine binds to 4 G protein-coupled receptors located on the cardiomyocyte (A1-R, A2a-R, A2b-R and A3-R) and modulates cardiac function during both ischemia and load-induced stress. While the role of adenosine receptor-subtypes has been well defined in the setting of ischemia-reperfusion, far less is known regarding their roles in protecting the heart during other forms of cardiac stress. We characterized the gene expression profiles of heart from A2a-R over-expressing mice subjected to transverse aortic constriction to study the potential of A2a-R activation to protect from pressure-induced heart failure.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6246

6 Samples

Download data: CEL

(Submitter supplied) Left ventricular mass (LVM) and cardiac gene expression are complex traits regulated by factors both intrinsic and extrinsic to the heart. To dissect the major determinants of LVM, we combined expression quantitative trait locus1 and quantitative trait transcript (QTT) analyses of the cardiac transcriptome in the rat. Using these methods and in vitro functional assays, we identified osteoglycin (Ogn) as a major candidate regulator of rat LVM, with increased Ogn protein expression associated with elevated LVM. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL96

27 Samples

Download data: CEL, CHP

(Submitter supplied) Comparative analysis of mouse cardiac left ventricle gene expression: voluntary wheel exercise and pregnancy-induced cardiac hypertrophy

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

18 Samples

Download data: CEL