Similar studies for GEO DataSets (Select 200242189) - GEO DataSets

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Items: 17

Select item 2002421891.

Maternal Western Diet Programs Cardiometabolic Dysfunction and Hypothalamic Inflammation via Epigenetic Mechanisms Predominantly in the Male Offspring

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing; Methylation profiling by high throughput sequencing

Platforms:: GPL21626 GPL19057
74 Samples

Download data: COV

Series

Accession:: GSE242189

ID:: 200242189

PubMed Full text in PMC Similar studies

Select item 2002421882.

Maternal Western Diet Programs Cardiometabolic Dysfunction and Hypothalamic Inflammation via Epigenetic Mechanisms Predominantly in the Male Offspring [miRNA-seq]

(Submitter supplied) Maternal exposure during pregnancy is a strong determinant of offspring health outcomes. Such exposures induce changes in the offspring epigenome resulting in gene expression and functional changes. In this study, we investigated the effect of maternal Western hypercaloric diet (HCD) programming during the perinatal period and its effect on neuronal plasticity and cardiometabolic health in adult offspring. more...

Organism:: Mus musculus

Type:: Non-coding RNA profiling by high throughput sequencing

Platform:: GPL21626
25 Samples

Download data: XLSX

Series

Accession:: GSE242188

ID:: 200242188

PubMed Full text in PMC Similar studies

Select item 2002421873.

Maternal Western Diet Programs Cardiometabolic Dysfunction and Hypothalamic Inflammation via Epigenetic Mechanisms Predominantly in the Male Offspring [RNA-seq]

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21626
25 Samples

Download data: CSV

Series

Accession:: GSE242187

ID:: 200242187

PubMed Full text in PMC Similar studies

Select item 2002421864.

Maternal Western Diet Programs Cardiometabolic Dysfunction and Hypothalamic Inflammation via Epigenetic Mechanisms Predominantly in the Male Offspring [Methyl-seq]

Organism:: Mus musculus

Type:: Methylation profiling by high throughput sequencing

Platform:: GPL19057
24 Samples

Download data: COV

Series

Accession:: GSE242186

ID:: 200242186

PubMed Full text in PMC Similar studies

Select item 2002614555.

Changes in miRNA expression in offspring hypothalamus after exposure to maternal obesity

(Submitter supplied) The purpose of this study was to identify miRNA that are differentially regulated in the arcuate nucleus of the hypothaamus (ARC) and paraventricular nucleus of the hypothalamus (PVH) after perinatal exposure to maternal obesity.

Organism:: Mus musculus

Type:: Non-coding RNA profiling by high throughput sequencing

Platform:: GPL21103
22 Samples

Download data: XLSX

Series

Accession:: GSE261455

ID:: 200261455

PubMed Full text in PMC Similar studies

Select item 2000820286.

Gene expression alternations in the offspring liver from chromium restriction diet dams

(Submitter supplied) Maternal chromium restriction may disturb susceptibility in offspring. Liver from maternal chromium diet has 264 up- and 199 down- regulated genes, compared to control. Especially, Insulin signaling pathway and WNT pathway were affected.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL16570
6 Samples

Download data: CEL

Series

Accession:: GSE82028

ID:: 200082028

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001613347.

Transcriptome analysis upon Hmg20a knockdown in astrocytes

(Submitter supplied) We recently demonstrated that the ‘Metabesity’ factor HMG20A is essential for beta cell functional maturity and adaptation to physiological stress. As this chromatin remodeling factor also dictates CNS development, we sought to determine whether HMG20A is expressed in astrocytes and whether it potentiates astrocyte function in response to environmental cues. To investigate the function and regulatory mechanism of HMG20A, RNA-seq was performed on astrocytes treated or not with a siHMG20A. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
4 Samples

Download data: TXT

Series

Accession:: GSE161334

ID:: 200161334

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001155358.

Maternal obesity has sex dependent effects on liver transcriptome in young adult rat offspring

(Submitter supplied) Maternal high-fat diet consumption predisposes to metabolic and liver dysfunction in F1 male and female at young adulthood. Purpose: We used RNA-seq to determine the liver transcriptome of male and female F1 of MO and control fed mothers. Methods: Female Wistar rat mothers ate control (C) or obesogenic (MO) diet from the time they were weaned through breeding at postnatal day (PND) 120, delivery and lactation. more...

Organism:: Rattus norvegicus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18694
22 Samples

Download data: TXT

Series

Accession:: GSE115535

ID:: 200115535

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001732189.

DNA methylation alternations in the offspring brown adipose tissue from high fat diet dams

(Submitter supplied) Maternal high fat diet may disturb susceptibility in offspring. Brown adipose tissue from maternal high fat diet has CpG sites that exhibit differential DNA methylationregulated compared to control.

Organism:: Mus musculus

Type:: Methylation profiling by genome tiling array

Platform:: GPL21852
6 Samples

Download data: TXT

Series

Accession:: GSE173218

ID:: 200173218

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20011923510.

Aberrant DNA methylation of hypothalamic angiotensin receptor in prenatal-programmed hypertension

(Submitter supplied) Malnutrition during pregnancy, which causes prenatal exposure to excessive glucocorticoid, induces adverse metabolic programming leading to hypertension in offspring. Pregnant rats receiving a low-protein diet exhibited moderate downregulation of 11-beta-dehydrogenase isozyme 2, which inactivates corticosterone, in the placenta, resulting in prenatal exposure to excessive corticosterone. In offspring of pregnant rats receiving a low-protein diet or dexamethasone, mRNA expression of angiotensin receptor type 1a (Agtr1a) in the paraventricular nucleus (PVN) of the hypothalamus was upregulated, concurrent with reduced expression of DNA methyltransferase 3a (Dnmt3a), reduced binding of DNMT3a to the Agtr1a promoter, and DNA demethylation, suggesting hypothalamic Agtr1a expression is epigenetically modulated by excess glucocorticoid. more...

Organism:: Rattus norvegicus

Type:: Expression profiling by array

Platform:: GPL14746
2 Samples

Download data: TXT

Series

Accession:: GSE119235

ID:: 200119235

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20004354711.

Genome-wide analysis of hypothalamic gene expression in prenatally undernourished male rat offspring under high fat diet

(Submitter supplied) Based on the developmental origin of health of disease hypothesis, we previously showed that prenatal 70% maternal food restriction (FR30) predisposes the offspring to development of pathologies in adulthood. In the present study, we focused on the hypothalamus gene expression profile of standard and high fat (HF)-fed FR30 adult offspring.

Organism:: Rattus norvegicus

Type:: Expression profiling by array

Platform:: GPL6101
4 Samples

Download data: TXT

Series

Accession:: GSE43547

ID:: 200043547

Select item 20004490112.

Maternal western diet primes susceptibility to hepatic inflamation in adult male mouse offspring

(Submitter supplied) Background & Aims: The influences of the maternal diet during gestation has been suggested to be involved in the development of different aspects of the metabolic syndrome. In our mouse model we characterised the role of maternal western diet in the development of non-alcoholic fatty liver disease (NAFLD) in the offspring. Methods: Female mice were fed either a western (W) or low-fat control (L) semi-synthetic diet before and during gestation and lactation. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Datasets:: GDS5293 GDS5342
Platform:: GPL6887
22 Samples

Download data: TXT

Series

Accession:: GSE44901

ID:: 200044901

Select item 534213.

Maternal western diet effect on post-weaning low-fat diet fed offspring liver

Analysis of liver of C57BL/6J male offspring exposed prenatally to a western-style diet (rich in energy, fat, cholesterol) or a low-fat diet and then a post-weaning low-fat diet. Results provide insight into the role of maternal western diet in the development of liver disease in offspring.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 2 protocol sets

Platform:: GPL6887
Series:: GSE44901
11 Samples

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DataSet

Accession:: GDS5342

ID:: 5342

Select item 529314.

Maternal western diet effect on post-weaning western diet fed offspring liver

Analysis of liver of C57BL/6J male offspring exposed prenatally to a western-style diet (rich in energy, fat, cholesterol) or a low-fat diet and then a post-weaning western diet. Results provide insight into the role of maternal western diet in the development of liver disease in offspring.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 2 protocol sets

Platform:: GPL6887
Series:: GSE44901
11 Samples

Download data

DataSet

Accession:: GDS5293

ID:: 5293

Select item 20009456915.

Microglia isolated from juvenile offspring of dams with allergic asthma exhibit methylation and transcriptional alterations to autism risk genes

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Methylation profiling by high throughput sequencing

Platforms:: GPL21493 GPL21103
16 Samples

Download data: BW, TXT

Series

Accession:: GSE94569

ID:: 200094569

PubMed Full text in PMC Similar studies

Select item 20009456816.

Microglia isolated from juvenile offspring of dams with allergic asthma exhibit methylation and transcriptional alterations to autism risk genes [WGBS]

(Submitter supplied) Asthma is one of the most common chronic diseases among pregnant women, and symptoms often worsen during pregnancy. Dysregulation in immune responses during pregnancy, such as those that develop with chronic allergic asthma, increase the risk of a having a child with an Autism Spectrum Disorder (ASD). We recently developed a mouse model of maternal allergic asthma (MAA) that induces alterations in behavioral outcomes of the offspring including changes in sociability, repetitive and perseverative behaviors. more...