Similar studies for GEO DataSets (Select 200235859) - GEO DataSets

Select item 2002358591.

Single Cell Analysis of a Mouse Model of Benign Prostate Hyperplasia Links Oxidative Stress to Progenitor Cell Properties

(Submitter supplied) scRNAseq of prostate cells from 6 and 8 month old Pb-PRL whole prostate mice with enlarged prostate after 28 days of treatment with antioxidant molecule; Anethole tritione (ATT) or coconut oil (vehicle).

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
4 Samples

Download data: H5

Series

Accession:: GSE235859

ID:: 200235859

PubMed Similar studies

Select item 2001789342.

Human prostate luminal epithelia adopt a club-like state in response to low androgen levels

(Submitter supplied) Spatial transcriptomics of treatment naive and 5-alpha reductase inhibitior treated human BPH tissue

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
8 Samples

Download data: H5, PNG

Series

Accession:: GSE178934

ID:: 200178934

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 2002005653.

Aberrant activation of canonical Notch1 signaling in the mouse prostate drives epithelialcell proliferation and induces prostatic hyperplasiaby increasing androgen receptor sensitivity

(Submitter supplied) To investigate the regulatory role of Notch1 signaling pathway in mouse prostate growth and development, we constructed mice with prostate-specific overactivation of Notch1 intracellular domain N1ICD, in which Notch1 signaling was overactivated in prostate epithelial cells. We then analyzed gene expression profiles in the prostates of overexpressed and normal Notch1 mice.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
6 Samples

Download data: TXT

Series

Accession:: GSE200565

ID:: 200200565

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Select item 2002422494.

Spatial transcriptomic profiles of prostate tissue obtained from a patient diagnosed with benign prostatic hyperplasia (BPH).

(Submitter supplied) ST profiles reveals the alterations in epithelial cells in Benign Prostatic Hyperplasia.

Organism:: Homo sapiens

Type:: Other

Platform:: GPL20795
1 Sample

Download data: CSV, JPG, JSON, PNG

Series

Accession:: GSE242249

ID:: 200242249

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Select item 2000178625.

Androgen Regulated Genes in Intact Human Prostate Tissues: Relation to Benign Prostatic Hyperplasia and Prostate Cancer

(Submitter supplied) To investigate gene expression profiling in intact human prostate tissue xenografts in mice, following the addition or subtraction of androgens.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL9035
58 Samples

Download data: GPR

Series

Accession:: GSE17862

ID:: 200017862

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Select item 2000776466.

Gene expression profiling of AR deletion in prostate luminal cells

(Submitter supplied) Benign prostatic hyperplasia (BPH) is a common urological disease that adversely affects quality of life among elderly males, but its etiology remains poorly understood. We show that the expression of the androgen receptor (AR) is decreased in the luminal epithelial cells of human BPH specimens and is inversely correlated with the degree of regional prostatic inflammation.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
4 Samples

Download data: TXT

Series

Accession:: GSE77646

ID:: 200077646

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Select item 2000653437.

Expression data from Incidental vs. Surgical BPH samples

(Submitter supplied) used to identify differences between tissues from patients undergoing surgery for BPH with unresolved symptoms compared to incidental BPH from patients with prostate cancer

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL17692
20 Samples

Download data: XLS

Series

Accession:: GSE65343

ID:: 200065343

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Select item 2000998248.

Molecular pathogenesis of human prostate basal cell hyperplasia reveals a keratinocyte metaplasia

(Submitter supplied) The incidence of basal cell hyperplasia (BCH) has been reported at 8-10%, but a molecular and cellular characterization has not been performed on this phenotype. Using freshly digested tissue from surgical specimens, we performed transcriptomic analysis of flow cytometry-purified basal epithelia from patients with and without a majority BCH phenotype. Gene set enrichment analysis revealed an increased expression of members of the epidermal differentiation complex, resembling the progression of other metaplastic diseases.