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Links from GEO DataSets

Items: 14

1.

Nrf2 and HIF1α merge to arsenic-induced metabolic reprogramming and formation of the cancer stem-like cells.

(Submitter supplied) Arsenic (iAs) induces generation of the cancer stem-like cells (CSCs) through Nrf2-dependent HIF1α activation, and the subsequent metabolic reprogramming from mitochondrial oxdaive phosphorylation to glycolysis in epithelial cells.
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL18573
5 Samples
Download data: BED
Series
Accession:
GSE145834
ID:
200145834
2.

Gene expression profiling of human prostate spheres and organoids exposed to inorganic arsenic (iAs)

(Submitter supplied) Gene expression analysis of prostate spheres and orgnoids in response to the inorganic arsenic exposure, to provide insight into the molecular mechenisms invovled in arsenic-induced homeostasis dysregulation of prostate stem-progenitor cells.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10558
12 Samples
Download data: TXT
Series
Accession:
GSE137357
ID:
200137357
3.

HIF1alpha drives early induction of pluripotency through reprogramming of glycolytic metabolism

(Submitter supplied) Gene expression analyis of two neonatal fibroblasts (BJ and HFF1), one adult dermal fibroblasts (NFH2), two BJ-derived human iPSCs (iB4 and iB5), two HFF1-derived iPSCs (iPS 2 and iPS4), four NFH2-derived iPSCs (OiPS3, OiPS6, OiPS8, OiPS16), one amniotic fluid cells and three derived iPSCs (lines 4, 5, 6, 10, and 41), two human ES cells (H1 and H9), neonatal fibroblasts transduced with the four retroviral factors (OKSM) after 24h, 48h, and 72h, neonatal fibroblasts treated with EDHB for 24h, 48h, and 72h, neonatal fibroblasts transduced with four factors and treated with EDHB for 24h, 48h, and 72h, neonatal fibroblasts knocked down for HIF1A (HIF1-KD) and for a scrambled sequence (SCR-KD)
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6883
48 Samples
Download data: TXT
Series
Accession:
GSE37709
ID:
200037709
4.

Nrf2 ChIP-seq data of Nrf2KO, wild-type and Keap1KO esophagus

(Submitter supplied) To understand how hyperactive NRF2 causes the esophageal phenotype in mice.
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL19057
4 Samples
Download data: TXT
Series
Accession:
GSE122504
ID:
200122504
5.

SIRT3 opposes metabolic reprogramming of cancer cells through HIF1a destabilization

(Submitter supplied) Tumor cells exhibit aberrant metabolism characterized by high glycolysis even in the presence of oxygen. This metabolic reprogramming, known as the Warburg effect, provides tumor cells with the substrates and redox potential required for the generation of biomass. Here, we show that the mitochondrial NAD-dependent deacetylase SIRT3 is a crucial regulator of the Warburg effect. SIRT3 loss promotes a metabolic profile consistent with high glycolysis required for anabolic processes in vivo and in vitro. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS4058
Platform:
GPL1261
10 Samples
Download data: CEL
Series
Accession:
GSE27309
ID:
200027309
6.
Full record GDS4058

SIRT3 knockout effect on brown adipose tissue

Analysis of brown adipose tissue of sirtuin SIRT3 knockout 129Sv males. SIRT3 is a crucial regulator of the Warburg effect, a metabolic reprogramming that provides tumor cells with the substrates required for biomass generation. Results provide insight into the role of SIRT3 in tumorigenesis.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 genotype/variation sets
Platform:
GPL1261
Series:
GSE27309
10 Samples
Download data: CEL
7.

Genome-wide profiling of gene expression/splicing patterns in iAs-transformed cells

(Submitter supplied) Chronic low dose inorganic arsenic (iAs) exposure leads to changes in gene expression and epithelial-to-mesenchymal transformation. During this transformation, cells adopt a fibroblast-like phenotype accompanied by profound gene expression changes. While many mechanisms have been implicated in this transformation, studies that focus on the role of epigenetic alterations in this process are just emerging. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platforms:
GPL17585 GPL17586
8 Samples
Download data: CEL, CHP
Series
Accession:
GSE90811
ID:
200090811
8.

Genome-wide profiling of DNA methylation patterns in iAs-transformed cells

(Submitter supplied) To examine the global impact of iAs on DNA methylation patterns. Genomic DNA was Bisulfite converted and analyzed using Mini methly-seq.
Organism:
Homo sapiens
Type:
Methylation profiling by high throughput sequencing
Platforms:
GPL18460 GPL11154
4 Samples
Download data: BIGBED
Series
Accession:
GSE85012
ID:
200085012
9.

RNA-sequencing data from PLC/PRF/5 cells with NC or USP22 knockdown (shUSP22) under hypoxic condition

(Submitter supplied) We use RNA-sequencing to evaluate the effect of USP22 knockdown on the gene changes in HCC cells
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21290
4 Samples
Download data: TXT
Series
Accession:
GSE133858
ID:
200133858
10.

HIF1α Regulates Early Metabolic Changes Due to Activation of Innate Immunity in Nuclear Reprogramming

(Submitter supplied) Innate immune signaling has recently been shown to play an important role in nuclear reprogramming, by altering the epigenetic landscape and thereby facilitating transcription. However, the mechanisms that link innate immune activation and metabolic regulation in pluripotent stem cells remain poorly defined, particularly with regards to key molecular components. In this study, we show that hypoxia-inducible factor one (HIF1α), a central regulator of adaptation to limiting oxygen tension, is an unexpected but crucial regulator of innate immune-mediated nuclear reprogramming. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17301
4 Samples
Download data: CSV
11.

Metabolic reprogramming of Kaposi’s sarcoma associated herpes virus infected B-cells in hypoxia

(Submitter supplied) We report differential gene expression in BJAB-KSHV/BJAB cells treated with Cobalt chloride/BJAB-KSHV cells treated with Cobalt Chloride compared to BJAB cells
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL11154
8 Samples
Download data: XLSX
12.

A functional map of genomic HIF1α-DNA complexes in the eye lens revealed through multiomics analysis

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Gallus gallus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL23499 GPL26853
10 Samples
Download data
Series
Accession:
GSE166633
ID:
200166633
13.

A functional map of genomic HIF1α-DNA complexes in the eye lens revealed through multiomics analysis [RNA-seq]

(Submitter supplied) Background: During eye lens development the fetal vasculature regresses leaving the lens without a direct oxygen source. Both embryonically and throughout adult life, the lens contains a decreasing oxygen gradient from the surface to the core that parallels the natural differentiation of immature surface epithelial cells into mature core transparent fiber cells. These properties of the lens suggest a potential role for hypoxia in the regulation of genes required for mature lens structure and function. more...
Organism:
Gallus gallus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL26853
6 Samples
Download data: TXT
Series
Accession:
GSE166632
ID:
200166632
14.

A functional map of genomic HIF1α-DNA complexes in the eye lens revealed through multiomics analysis [CUT&RUN]

(Submitter supplied) Background: During eye lens development the fetal vasculature regresses leaving the lens without a direct oxygen source. Both embryonically and throughout adult life, the lens contains a decreasing oxygen gradient from the surface to the core that parallels the natural differentiation of immature surface epithelial cells into mature core transparent fiber cells. These properties of the lens suggest a potential role for hypoxia in the regulation of genes required for mature lens structure and function. more...
Organism:
Gallus gallus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL23499
4 Samples
Download data: BEDGRAPH, TXT
Series
Accession:
GSE166626
ID:
200166626
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