GEO DataSets

(Submitter supplied) Irradiated hosts gave rise to significantly more Trp53 null mammary cancers that grew more rapidly than those in sham-irradiated mice and exhibited an immunosuppressive tumor microenvironment . CAPE prevented the effect of host irradiation on tumor growth rate, immune signature and immunosuppression.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL17021

23 Samples

Download data: TXT

(Submitter supplied) To determine how host irradiation affects tumor profiles in 10 month aged mice treated with HZE or gamma irradiation.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL16570

43 Samples

Download data: CEL

(Submitter supplied) Densely ionizing radiation is a major component of the space radiation environment and has potentially greater carcinogenic effect compared to sparsely ionizing radiation that is prevalent in the terrestrial environment. It is unknown to what extent the irradiated microenvironment contributes to the differential carcinogenic potential of densely ionizing radiation. To address this gap, 10-week old BALB/c mice were irradiated with 100 cGy sparsely ionizing g-radiation or 10, 30, or 80 cGy of densely ionizing, 350 MeV/amu Si particles and transplanted 3 days later with syngeneic Trp53 null mammary fragments. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL11533

45 Samples

Download data: CEL

(Submitter supplied) It is widely believed that the carcinogenic action of ionizing radiation is due to targeted DNA damage and resulting mutations, but there is also substantial evidence that non-targeted radiation effects alter epithelial phenotype and the stromal microenvironment. Activation of transforming growth factor β1 (TGFβ) is a non-targeted radiation effect that mediates cell fate decisions following DNA damage and regulates microenvironment composition; it could either suppress or promote cancer. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

65 Samples

Download data: CEL

(Submitter supplied) We developed a mouse model that captures radiation effects on host biology by transplanting unirradiated Trp53 null mammary tissue to sham or irradiated hosts. Gene expression profiles of tumors that arose in irradiated mice are distinct from those that arose in naïve hosts. Host irradiation induces a metaprofile consisting of gene modules representing stem cells, cell motility, macrophages and autophagy. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Datasets:

GDS4768 GDS4769

Platform:

GPL1261

56 Samples

Download data: CEL

Analysis of Trp53-null tumors arising from Tgfb1+/- hosts cleared of mammary gland epithelia, irradiated, then transplanted with nonmalignant Trp53-null mammary tissue. TGF-β drives EMT and is highly induced by IR. Results provide insight into host biology contributions to radiation carcinogenesis.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 protocol sets

Platform:

GPL1261

Series:

GSE42742

24 Samples

Download data: CEL

Analysis of Trp53-null mammary tumors arising from WT hosts cleared of mammary gland epithelium, irradiated, then transplanted with nonmalignant Trp53-null mammary tissue. Results provide insight into the influence of the radiation response of the microenvironment on the carcinogenic process.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 protocol sets

Platform:

GPL1261

Series:

GSE42742

32 Samples

Download data: CEL

(Submitter supplied) Gene expression for genes differentially expressed between early vs. late tumor onset and high fat diet (HFD) vs. low fat diet (LFD) in P53 -/- mice.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL11202

41 Samples

Download data: TXT

(Submitter supplied) Age and physiological status like menopause are key factors in mammary development and are associated with breast cancer risk. Less clear is what factors influence breast cancer intrinsic subtypes that are associated with prognosis. Here, we investigated the age of the host in a mammary chimera model. The mammary glands of wildtype BALB/c mice were cleared of endogenous epithelium at 3 weeks of age and subsequently transplanted during puberty (5 weeks) or upon maturation (10 weeks) with syngeneic Trp53null mammary fragments. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6887

27 Samples

Download data: TXT

(Submitter supplied) To investigate mTDT transcriptional features using the Nanostring pancancer io 360 gene expression panel that consists of 770 unique genes involved in the interplay between the tumor, microenvironment and immune response.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL28689

24 Samples

Download data: RCC

(Submitter supplied) Although various mechanisms have been inferred for combinatorial actions of multiple carcinogens, these mechanisms have not been well demonstrated in experimental carcinogenesis models. We evaluated mammary carcinogenesis initiated by combined exposure to various doses of radiation and chemical carcinogens. Female rats at 7 weeks of age were γ-irradiated (0.2–2 Gy) and/or exposed to 1-methyl-1-nitrosourea (20 or 40 mg/kg, single intraperitoneal injection) or 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (40 mg/kg/day by gavage for 10 days) and were observed until 50 weeks of age. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1355

36 Samples

Download data: CEL, CHP

(Submitter supplied) This study investigates three radiation exposure scenarios in BALB/c and C57BL/6 mice: (1) low dose (LD) group -- four weekly doses of 7.5 cGy, (2) high dose (HD) group -- four weekly doses of 1.8 Gy, (3) unexposed group -- four weekly sham exposures. We then used comparative expression profiles of the mouse mammary gland and cardiac blood to build a model of candidate tissue functions associated with LD cancer susceptibility in these strains and murine and human knowledgebases to characterize these tissue functions and their relevance to breast cancer.

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS4323

Platform:

GPL8759

51 Samples

Download data: CEL

Analysis of mammary gland from BALB/c and C57BL/6 females exposed to low dose (LD) ionizing radiation. The two inbred strains differ in their genetic susceptibility to radiation-induced mammary cancer. Results provide insight into molecular mechanisms underlying mammary cancer susceptibility.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 4 dose, 2 strain, 3 time, 2 tissue sets

Platform:

GPL8759

Series:

GSE40066

51 Samples

Download data: CEL

(Submitter supplied) The tumor suppressor gene p53 is frequently mutated in human breast cancer and is a marker for poor prognosis and resistance to chemotherapy. Transplantation of p53-null mouse mammary epithelium into syngeneic wild-type mice leads to normal mammary gland development followed by spontaneous mammary tumors that recapitulate many of the phenotypic, molecular, and genetic features of human breast cancer. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6096

6 Samples

Download data: CEL

(Submitter supplied) Macrophages, dendritic cells, conventional CD4+ T cells, CD8+ T cells, and regulatory T cells isolated from mouse colon cancer model MC38 tumors implanted subcutaneously to young (3 month) and aged (12 month) mice were sequenced using ImmGen's standard ultra-low input RNA-seq pipeline, in order to study age-dependent differences in intraltumoral immune cell functions and their impact on tumor control

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL19057

74 Samples

Download data: TXT

(Submitter supplied) We studied the role of S1PR4 on tumor progression using the PyMT mammary carcinoma mouse model and the AOM/DSS model for colitis-associated cancer. To gain insights of the underlying mechanism how S1PR4 ablation resulted in enhanced intratumoral CD8+ T cell abundance, we performed whole transcriptome profiling of total WT and S1PR4 KO colons subjected to the AOM/DSS model (day 84) as well as FACS-sorted CD8+ T cells from WT and S1PR4 KO tumors of PyMT mice. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL13112 GPL19057

12 Samples

Download data: TXT

(Submitter supplied) The goal of this study is to identify differentially expressed genes in colorectal tumor samples enriched for exhausted T cells. CD38 expression was used as a representative marker for T cell exhaustion. The comparison was made between CD38high (top 33rd percentile of all samples) and CD38low (bottom 33rd percentile of all samples) samples.

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL20301

19 Samples

Download data: TSV

(Submitter supplied) Irradiation of the K-rasLA1 mouse model with a fractionated dose of 1.0Gy 56Fe- particles increases the incidence of invasive carcinoma compared to unirradiated controls or those irradiated with an acute dose. Microarray profiling was perfromed on whole lungs from K-rasLA1 mice in order to determine global expression changes in the lung following radiation exposure. RNA was extracted from K-rasLA1 lungs from unirradiated control animals or those irradiated with a fractionated or acute dose of 1.0Gy 56Fe- particles 70 days post-irradiation when lungs are still histologically indistiguishable and only contain benign lesions.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6887

42 Samples

Download data: TXT

(Submitter supplied) Previous work has demonstrated the potential for peripheral blood (PB) gene expression profiling for the detection of disease or environmental exposures. We have sought to determine the impact of several variables on the PB gene expression profile of an environmental exposure, ionizing radiation, and to determine the specificity of the PB signature of radiation versus other genotoxic stresses. Keywords: peripheral blood, gene expression study, radiation reponse

Organism:

Homo sapiens; Mus musculus

Type:

Expression profiling by array

4 related Platforms

335 Samples

Download data: GPR