Similar studies for GEO DataSets (Select 200121600) - GEO DataSets

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Items: 20

Select item 2001216001.

Single-cell RNA-seq reveals novel cell differentiation dynamics during human airway epithelium regeneration

(Submitter supplied) The upper airway epithelium is mainly composed of 4 cell types: multiciliated, goblet, secretory and basal cells. It constitutes an efficient first line of defense of the respiratory tract against a large panel of inhaled substances. Upon injury, regeneration of this epithelium through proliferation and differentiation events can restore a proper mucociliary function. In chronic airway diseases, such as chronic obstructive pulmonary disease or asthma, the injured epithelium frequently displays defective repair leading to tissue remodeling, characterized by a loss of multiciliated cells and mucus hyper-secretion. more...

Organism:: Homo sapiens; Sus scrofa; Mus musculus

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL19057 GPL18573 GPL20983
22 Samples

Download data: H5

Series

Accession:: GSE121600

ID:: 200121600

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2002453922.

IL-4 drastically decreases deuterosomal and multiciliated cells via alteration in progenitor cell differentiation

(Submitter supplied) Allergic inflammation affects the epithelial cell populations resulting in goblet cell hyperplasia and decreased ciliated cells. In this study, we aimed to investigate the effect of allergic inflammation in nasal epithelial cell transcriptomes at the single-cell level. We performed scRNAseq in cultured primary human nasal epithelial (HNE) cells and in vivo nasal epithelium. The transcriptomic features and epithelial cell subtypes were determined under IL-4 stimulation, and cell-specific marker genes and proteins were identified. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20795
4 Samples

Download data: MTX, TSV

Series

Accession:: GSE245392

ID:: 200245392

PubMed Similar studies

Select item 2001033543.

A revised airway epithelial hierarchy includes CFTR-expressing ionocytes

(Submitter supplied) Airways conduct gases to the lung and are disease sites of asthma and cystic fibrosis. Here we study the cellular composition and hierarchy of the mouse tracheal epithelium by single-cell RNA-sequencing (scRNA-seq) and in vivo lineage tracing. We identify a rare cell type, the Foxi1+ pulmonary ionocyte; functional variations in club cells by proximodistal location; a distinct cell type in high turnover squamous epithelial structures that we term 'hillocks'; and disease-relevant subsets of tuft and goblet cells. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
325 Samples

Download data: MTX, RDS, TSV, TXT

Series

Accession:: GSE103354

ID:: 200103354

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Select item 2000690584.

Gene expression data from mouse tracheal cells before and 48hrs after SO2 injury

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
12 Samples

Download data: CEL

Series

Accession:: GSE69058

ID:: 200069058

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000690575.

Gene expression data from mouse tracheal mesenchymal cells before and 48hrs after SO2 injury

(Submitter supplied) The conducting airway epithelium of the rodent and human lung is underlaid by mesenchymal cells that include vasculature, smooth muscle, fibroblasts and cartilage. The goal of this project is to identify cellular and molecular changes in the mesenchyme after injury to the epithelium by exposure to SO2 and which may participate in repair of the epithelium We used Affymetrix microarray analysis to compare transcripts in tracheal mesenchyme before and after SO2 injury.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
6 Samples

Download data: CEL

Series

Accession:: GSE69057

ID:: 200069057

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Select item 2000690566.

Gene expression data from mouse tracheal epithelial cells isolated before and 48hrs after SO2 injury

(Submitter supplied) The conducting airway epithelium of the rodent and human lung is made up of about equal proportions of ciliated and secretory cells. In addition, in regions where the epithelium is pseudostratfied, ~30% of the epithelium consists of undifferentiated basal cells (BCs). Evidence suggests that these BCs are multipotent stem cells that can self renew over the long term and give rise to both ciliated and secretory lineages. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
6 Samples

Download data: CEL

Series

Accession:: GSE69056

ID:: 200069056

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Select item 2001025807.

A single cell atlas of the airway epithelium reveals the CFTR-rich pulmonary ionocyte

(Submitter supplied) The functions of epithelial tissues are dictated by the types, abundance, and distribution of the differentiated cells they contain. Attempts to restore tissue function after damage require knowledge of how physiological tasks are distributed among cell types, and how cell states vary between homeostasis, injury/repair, and disease. In the conducting airway, a heterogeneous basal cell population gives rise to specialized luminal cells that perform mucociliary clearance. more...

Organism:: Homo sapiens; Mus musculus

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL19057 GPL18573
15 Samples

Download data: TSV

Series

Accession:: GSE102580

ID:: 200102580

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Select item 2000052648.

Human bronchial epithelial cell differentiation time course

(Submitter supplied) Microarray analysis was performed to identify transcriptional changes that occur during mucociliary differentiation of human primary bronchial epithelial cells cultured at an air-liquid interface (ALI). Keywords: time course

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS2615
Platform:: GPL570
30 Samples

Download data: CEL

Series

Accession:: GSE5264

ID:: 200005264

Select item 26159.

Mucociliary differentiation of airway epithelial cells

Analysis of primary airway epithelial cells cultured at an air-liquid interface for up to 28 days to induce their differentiation into polarized, pseudostratified epithelia of ciliated and mucus-secreting cells. Results provide insight into the mechanisms underlying mucociliary differentiation.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 3 individual, 11 time sets

Platform:: GPL570
Series:: GSE5264
30 Samples

Download data: CEL

DataSet

Accession:: GDS2615

ID:: 2615

Select item 20006900510.

Rapid expansion of human epithelial stem cells suitable for airway tissue engineering

(Submitter supplied) Rationale: Stem cell-based tracheal replacement represents an emerging therapeutic option for patients with otherwise untreatable airway diseases including long-segment congenital tracheal stenosis and upper airway tumors. Clinical experience suggests an urgent need to restore mucociliary function in the lungs following transplantation of tissue-engineered grafts, while pre-clinical studies show that seeding scaffolds with autologous mucosa improves regeneration. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10558
8 Samples

Download data: TXT

Series

Accession:: GSE69005

ID:: 200069005

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20023314511.

COPD basal cells are primed towards secretory to multi-ciliated cell imbalance driving increased resilience to environmental stressors

(Submitter supplied) We characterized primary human bronchial epithelial cells (pHBECs) from end-stage COPD and pulmonary healthy individuals. The transcriptomic profiles were assessed by single cell analysis in serial samples of pHBEC culture focussing on basal cell differentiation.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20301
29 Samples

Download data: H5AD, TXT

Series

Accession:: GSE233145

ID:: 200233145

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Select item 20020866212.

COPD basal cells are primed towards secretory to multi-ciliated cell imbalance driving increased resilience to environmental stressors

(Submitter supplied) Introduction: Environmental pollutants irritate and injure the bronchial elevator, thereby provoking disease progression in chronic obstructive pulmonary disease (COPD). Epithelial resilience mechanisms to environmental nanoparticles in health and disease are poorly characterized. Methods: We delineated the impact of prevalent pollutants such as carbon and zinc oxide nanoparticles, on cellular function and progeny in primary human bronchial epithelial cells (pHBEC) from end-stage COPD, early disease and pulmonary healthy individuals. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL23159
32 Samples

Download data: CEL

Series

Accession:: GSE208662

ID:: 200208662

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Select item 20015808813.

Development of Xenopus Mucociliary Epithelium

(Submitter supplied) Here we profile 10 distinct Xenopus MCE developmental stages throughout embryogenesis and characterise the expression patterns and state transition accompanying cell-fate decisions.

Organism:: Xenopus laevis

Type:: Expression profiling by high throughput sequencing

Platform:: GPL25291
10 Samples

Download data: TAR

Series

Accession:: GSE158088

ID:: 200158088

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Select item 20004619414.

Multiple roles for Grainyhead-like transcription factors in the establishment and maintenance of human mucociliary airway epithelium (ChIP-Seq)

(Submitter supplied) The airways of the human lung are lined by an epithelium made up of ciliated and secretory luminal cells and undifferentiated p63+ Krt5+ basal cells. The integrity of this epithelium and its ability to act as a selective barrier are critical for normal lung function. In other epithelia there is evidence that transcription factors of the evolutionarily conserved grainyheadlike (GRHL) family play key roles in co-ordinating the expression of numerous proteins required for epithelial morphogenesis, differentiation, remodeling and repair. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL11154
6 Samples

Download data: BEDGRAPH

Series

Accession:: GSE46194

ID:: 200046194

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20004480915.

Primary human bronchial epithelial cells expressing EGFP or DN-GRHL2

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
12 Samples

Download data: CEL

Series

Accession:: GSE44809

ID:: 200044809

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Select item 20004480816.

Gene expression data from primary human bronchial epithelial cells expressing EGFP or DN-GRHL2 for 48h

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
6 Samples

Download data: CEL

Series

Accession:: GSE44808

ID:: 200044808

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Select item 20004480717.

Gene expression data from primary human bronchial epithelial cells expressing EGFP or DN-GRHL2

(Submitter supplied) The airways of the human lung are lined by an epithelium made up of ciliated and secretory luminal cells and undifferentiated p63+ Krt5+ progenitors. The integrity of this epithelium and its ability to act as a selective barrier are critical for normal lung function. In other epithelia there is evidence that transcription factors of the evolutionarily conserved grainyheadlike (GRHL) family play key roles in co-ordinating the expression of numerous proteins required for epithelial morphogenesis, differentiation, remodeling and repair. more...