GEO DataSets

(Submitter supplied) Sirtuin 3 (SIRT3) is an NAD+-dependent deacetylase downregulated in aging and age-associated diseases such as cancer and neurodegeneration, and high fat diet (HFD)-induced metabolic disorders. Thus, we performed a small molecule screen and identified an unexpected metabolic vulnerability associated with SIRT3 loss.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL19057

5 Samples

Download data: TXT

(Submitter supplied) Diffuse large B-cell lymphomas (DLBCLs) are genetically heterogeneous and highly proliferative neoplasms derived from germinal center (GC) B-cells. Herein, we show that DLBCLs are dependent on mitochondrial lysine deacetylase SIRT3 for proliferation, survival, self-renewal, and tumor growth in vivo regardless of disease subtype and genetics. SIRT3 knockout attenuated B-cell lymphomagenesis in VavP-Bcl2 mice without affecting normal GC formation. more...

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL16791

63 Samples

Download data: TXT

(Submitter supplied) Tumor cells exhibit aberrant metabolism characterized by high glycolysis even in the presence of oxygen. This metabolic reprogramming, known as the Warburg effect, provides tumor cells with the substrates and redox potential required for the generation of biomass. Here, we show that the mitochondrial NAD-dependent deacetylase SIRT3 is a crucial regulator of the Warburg effect. SIRT3 loss promotes a metabolic profile consistent with high glycolysis required for anabolic processes in vivo and in vitro. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS4058

Platform:

GPL1261

10 Samples

Download data: CEL

Analysis of brown adipose tissue of sirtuin SIRT3 knockout 129Sv males. SIRT3 is a crucial regulator of the Warburg effect, a metabolic reprogramming that provides tumor cells with the substrates required for biomass generation. Results provide insight into the role of SIRT3 in tumorigenesis.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 genotype/variation sets

Platform:

GPL1261

Series:

GSE27309

10 Samples

Download data: CEL

(Submitter supplied) SIRT3 is a mitochondrial NAD(+)-dependent protein deacetylase, which regulates the enzymatic activity of several mitochondrial proteins. We used microarrays to identify the differences in gene expression as a result of loss of SIRT3, under standard and high-fat diet conditions

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS4817

Platform:

GPL6246

12 Samples

Download data: CEL

Analysis of livers of mitochondrial protein deacetylase SIRT3 null mutants on a high fat diet (HFD). SIRT3 null mutants on a HFD exhibit obesity, insulin resistance, hyperlipidemia, and steatohepatitis. Results provide insight into molecular basis of metabolic dysfunction in SIRT3-deficient livers.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 genotype/variation, 2 protocol sets

Platform:

GPL6246

Series:

GSE30552

12 Samples

Download data: CEL