GEO DataSets

(Submitter supplied) The effect of cyclic mecanical stretch on cardiac microRNA expression was studied in neonatal rat ventricular myocytes (NRVMs).

Organism:

human gammaherpesvirus 4; Betapolyomavirus macacae; Murid gammaherpesvirus 4; Rattus norvegicus; JC polyomavirus; Human gammaherpesvirus 8; Betapolyomavirus hominis; Homo sapiens; Mus musculus; Human alphaherpesvirus 1; Human betaherpesvirus 5; Murid betaherpesvirus 1; Human immunodeficiency virus 1

Type:

Non-coding RNA profiling by array

Platform:

GPL7722

9 Samples

Download data: XLS

(Submitter supplied) The effect of cyclic mecanical stretch on cardiac gene expression was studied in neonatal rat ventricular myocytes (NRVMs).

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1355

35 Samples

Download data: CEL, CHP

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Murid gammaherpesvirus 4; Betapolyomavirus hominis; Rattus norvegicus; human gammaherpesvirus 4; JC polyomavirus; Human gammaherpesvirus 8; Betapolyomavirus macacae; Homo sapiens; Mus musculus; Human alphaherpesvirus 1; Human betaherpesvirus 5; Murid betaherpesvirus 1; Human immunodeficiency virus 1

Type:

Non-coding RNA profiling by array

Platform:

GPL7722

20 Samples

Download data

(Submitter supplied) The effect of cyclic mecanical stretch on cardiac microRNA expression was studied in neonatal rat ventricular myocytes (NRVMs).

Organism:

Mus musculus; Human gammaherpesvirus 8; Human alphaherpesvirus 1; human gammaherpesvirus 4; Betapolyomavirus macacae; Rattus norvegicus; JC polyomavirus; Murid gammaherpesvirus 4; Betapolyomavirus hominis; Homo sapiens; Human betaherpesvirus 5; Murid betaherpesvirus 1; Human immunodeficiency virus 1

Type:

Non-coding RNA profiling by array

Platform:

GPL7722

11 Samples

Download data: XLS

(Submitter supplied) Neonatal rat ventricular cardiomyocytes (NRVCMs) were stretched biaxially (112%/24h) or stimulated with phenylephrine (PE, 50 uM), both resulting in a similar degree of hypertrophy. Unstretched NRVCMs served as negative control. Affymetrix microarray analysis revealed 164 genes more than 2.0-fold up- and 21 genes less than 0.5-fold downregulated (p<0.01). Differential expression was confirmed by real-time PCR. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS3117

Platform:

GPL1355

6 Samples

Download data: CEL

Analysis of neonatal ventricular cardiomyocytes subjected to both biomechanical stretch stress and pharmacological (i.e., phenylephrine, PE) induction of hypertrophy. Results provide insight into how mechanical stress is sensed and transduced in cardiomyocytes on the molecular level.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, transformed count, 3 protocol sets

Platform:

GPL1355

Series:

GSE5996

6 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Rattus norvegicus

Type:

Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platform:

GPL20084

6 Samples

Download data: BW

(Submitter supplied) We examined Glucocorticoid receptor binding sites in isolated neonatal cardiomyocytes treated with Dexamethasone (100nM) for 1hr or Ethanol using GR-ChIP-Seq. In addition to determine the change in the resulting transcriptional status of genes we performed RNAseq in cardiomyocytes treated with Dexamethasone (100nM) or Ethanol for 1hr or 24hrs.

Organism:

Rattus norvegicus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL20084

3 Samples

Download data: PDF, XLSX

(Submitter supplied) We examined Glucocorticoid receptor binding sites in isolated neonatal cardiomyocytes treated with Dexamethasone (100nM) for 1hr or Ethanol using GR-ChIP-Seq.

Organism:

Rattus norvegicus

Type:

Genome binding/occupancy profiling by high throughput sequencing

Platform:

GPL20084

3 Samples

Download data: BW, PDF, XLSX

(Submitter supplied) Accute stretch and tachycardia are capable of inducing pathological excitation transcription coupling - an early invent before structural cardiac remodeling which transitions to heart failure. The sodium calcium exchanger is a key player in maintaining calcium homeostasis and is implicated in pathological signaling during heart failure. Neonatal rat ventricular cardiomyocytes (NRVCM) were subjected to mechanical stress and high freqency elecrical stimulation to study genes regulated during the early phase of trigger induced cardiac remodeling. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL19271

18 Samples

Download data: CEL

(Submitter supplied) Cyclic stretch of alveoli is characteristic of mechanical ventilation, and is postulated to be partly responsible for the lung injury and inflammation in ventilator induced lung injury. We propose that miRNAs may regulate some of the stretch response and, therefore, hypothesized that miRNAs would be differentially expressed between stretched and unstretched rat alveolar epithelial cells (RAECs).

Organism:

Homo sapiens; Human alphaherpesvirus 1; Human betaherpesvirus 5; human gammaherpesvirus 4; Betapolyomavirus macacae; Rattus norvegicus; Murid gammaherpesvirus 4; Betapolyomavirus hominis; Mus musculus; Murid betaherpesvirus 1; JC polyomavirus; Human immunodeficiency virus 1; Human gammaherpesvirus 8

Type:

Non-coding RNA profiling by array

Platform:

GPL7722

12 Samples

Download data: GPR

(Submitter supplied) Gene expression changes in neonatal rat ventricular myocytes plated in fibronectin (2 samples) or uncoated plates (2 samples). Keywords = Hypertrophy Cardiac Myocyte Fibronectin Keywords: repeat sample

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS696

Platform:

GPL341

4 Samples

Download data

Examination of neonatal ventricular myocytes plated on fibronectin coated dishes. Fibronectin elicits a hypertrophic response by clustering integrin receptors. Results provide insight into molecular events underlying cardiac hypertrophy.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 protocol sets

Platform:

GPL341

Series:

GSE1055

4 Samples

Download data

(Submitter supplied) The aim of the experiment was to determine the effect of cyclic stretch-relaxation ("stretch") on gene expression patterns in normal diploid human bladder smooth muscle cells. Cells plated on silicone elastomer bottomed 6-well culture dishes were grown to ~80% confluence, serum-depleted for 48h and subjected to cyclic stretch-relaxation at 20% elongation for 4h. Cells seeded in stretch plates but not subjected to stretch served as controls. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS906

Platform:

GPL96

8 Samples

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Expression profiling of cultured bladder smooth muscle cells subjected to repetitive mechanical stimulation for 4 hours. Chronic overdistension results in bladder wall thickening, associated with loss of muscle contractility. Results identify genes whose expression is altered by mechanical stimuli.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 protocol sets

Platform:

GPL96

Series:

GSE1595

8 Samples

Download data

(Submitter supplied) To identify differentially expressed miRNAs in human trabecular meshwork (HTM) cells in response to cyclic mechanical stretch

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL24158

12 Samples

Download data: RCC, TXT

(Submitter supplied) Several different mechanical signals have been proposed to control the extent and pattern of myocardial growth and remodeling, though this has largely been studied using in vitro model systems that are not representative of intact myocardium or in vivo models in which isolating the effects of individual candidate stimuli is exceedigly difficult. We used a unique tissue culture system that allows the simultaneous control of multiple mechanical inputs and other potentially confounding stimuli (e.g., hormonal). more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1355

12 Samples

Download data: CEL, TXT