Similar studies for GEO DataSets (Select 200094751) - GEO DataSets

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Items: 20

Select item 2000947511.

Global transcriptome profiling identifies KLF15 and SLC25A10 as regulators of adipocytes insulin sensitivity in obese women [siRNA]

(Submitter supplied) The aim of this study was to identify new genes controlling insulin sensitivity in adipocytes from obese women with either insulin-resistant (OIR) or -sensitive (OIS) adipocytes. 432 genes were differentially expressed between the OIR and OIS group (FDR <5%). These genes are enriched in pathways related to glucose and amino acid metabolism, cellular respiration, and insulin signaling. Two IR-associated genes, KLF15 and SLC25A10, were selected for functional evaluation.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL17692
23 Samples

Download data: CEL

Series

Accession:: GSE94751

ID:: 200094751

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000947532.

Global transcriptome profiling identifies KLF15 and SLC25A10 as regulators of adipocytes insulin sensitivity in obese women

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platforms:: GPL11532 GPL17692
71 Samples

Download data: CEL

Series

Accession:: GSE94753

ID:: 200094753

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000947523.

Global transcriptome profiling identifies KLF15 and SLC25A10 as regulators of adipocytes insulin sensitivity in obese women [WAT]

(Submitter supplied) The aim of this study was to identify new genes controlling insulin sensitivity in adipocytes from obese women with either insulin-resistant (OIR) or -sensitive (OIS) adipocytes. 432 genes were differentially expressed between the OIR and OIS group (FDR <5%). These genes are enriched in pathways related to glucose and amino acid metabolism, cellular respiration, and insulin signaling, and include SLC2A4, AKT2, as well as enzymes in the mitochondria respiratory chain. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL11532
48 Samples

Download data: CEL

Series

Accession:: GSE94752

ID:: 200094752

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000873794.

Comprehensive functional screening of miRNAs involved in human fat cell insulin sensitivity

(Submitter supplied) The aim of this study was to detect and functionally investigate miRNAs linked to insulin sensitivity in human subcutaneous white adipose tissue (scWAT). Subjects were selected based on the insulin-stimulated lipogenesis response of subcutaneous adipocytes. Eleven miRNAs displayed differential expression between OIR and OIS states. Overexpression of miR-143-3p and miR-652-3p increased insulin-stimulated lipogenesis in human in vitro-differentiated adipocytes. more...

Organism:: synthetic construct; Homo sapiens

Type:: Non-coding RNA profiling by array

Platform:: GPL8786
48 Samples

Download data: CEL

Series

Accession:: GSE87379

ID:: 200087379

Select item 2000763995.

The epigenetic signature of systemic insulin resistance in obese women

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Methylation profiling by genome tiling array

Platform:: GPL13534
236 Samples

Download data

Series

Accession:: GSE76399

ID:: 200076399

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000763986.

The epigenetic signature of systemic insulin resistance in obese women [SC]

(Submitter supplied) Impaired ability of insulin to stimulate cellular glucose uptake and regulate metabolism, that is insulin resistance (IR), links adiposity to metabolic disorders such as type 2 diabetes (T2D), dyslipidemia and cardiovascular disease (Langenberg, 2012). Both genetic and epigenetic factors are implicated in development of systemic IR (Vaag, 2001). IR is characterized by elevated levels of fasting insulin in the general circulation. more...

Organism:: Homo sapiens

Type:: Methylation profiling by genome tiling array

Platform:: GPL13534
77 Samples

Download data: TXT

Series

Accession:: GSE76398

ID:: 200076398

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000763947.

The epigenetic signature of systemic insulin resistance in obese women [OM]

Organism:: Homo sapiens

Type:: Methylation profiling by genome tiling array

Platform:: GPL13534
79 Samples

Download data: TXT

Series

Accession:: GSE76394

ID:: 200076394

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000762858.

The epigenetic signature of systemic insulin resistance in obese women [BL]

Organism:: Homo sapiens

Type:: Methylation profiling by genome tiling array

Platform:: GPL13534
80 Samples

Download data: TXT

Series

Accession:: GSE76285

ID:: 200076285

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001014929.

LONG NON-CODING RNAs ASSOCIATED WITH METABOLIC TRAITS IN HUMAN WHITE ADIPOSE TISSUE

(Submitter supplied) The aim of this study was to identify novel long noncoding RNAs (lncRNAs) that are differentially expressed in the subcutaneous region either in obesity or insulin resistance. A number of novel lncRNAs were differentially expressed in the subcutaneous region either in obesity or insulin resistance. Two lncRNAs (termed here as adipocyte specific insulin resistance related lncRNAs (ADLNRIs), ADLNRI 1 and ADLNRI 2) were influenced by both conditions and enriched in adipocytes. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL20265
80 Samples

Download data: CEL

Series

Accession:: GSE101492

ID:: 200101492

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20008065410.

FACS sorting of human adipose tissue stromal vascular fraction

(Submitter supplied) Adipose tissue from 6 non-obese patients was collagenase treated and adipocytes separated from the stromal vascular fraction(SVF). SVF was then FACS sorted for the following fractions CD45-/CD34+/CD31+ (endothelial), CD45-/CD34+/CD31- (progenitor), CD45+/CD14+ (monocyte/macrophage), CD45+/CD14-(Leukocyte). RNA was isolated from adipocyte, SVF, progenitor, macrophage/monocyte and leukocyte fractions and analyzed on the Affymetrix Human Transcriptome 2.0 array. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL17586
51 Samples

Download data: CEL

Series

Accession:: GSE80654

ID:: 200080654

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20004122311.

LXR activation induces insulin resistance in primary human adipocytes

(Submitter supplied) The effects of LXR stimulation by GW3965 treatment on global mRNA and miRNA expression in primary human in vitro differentiated adipocytes was investigated using microarray profiling.

Organism:: Homo sapiens; synthetic construct

Type:: Expression profiling by array; Non-coding RNA profiling by array

Platforms:: GPL6244 GPL8786
44 Samples

Download data: CEL

Series

Accession:: GSE41223

ID:: 200041223

Select item 20000870012.

Expression data from epididymal fat tissues of diet induced obese rats

(Submitter supplied) Analysis of gene expression profiles of epididymal fat from DIO rats We applied a comparative functional genomics approach to evaluate diet-induced obese (DIO) rats as an obesity model Keywords: single time point, comparison control animal vs. diet induced obese animal

Organism:: Rattus norvegicus

Type:: Expression profiling by array

Dataset:: GDS2946
Platform:: GPL1355
15 Samples

Download data: CEL

Series

Accession:: GSE8700

ID:: 200008700

Select item 294613.

Diet-induced obesity model: epididymal fat tissue

Comparison of epididymal fat tissues from diet-induced obese (DIO) and lean animals. DIO animals were fed a high fat, high sucrose diet to induce obesity.

Organism:: Rattus norvegicus

Type:: Expression profiling by array, count, 2 individual sets

Platform:: GPL1355
Series:: GSE8700
15 Samples

Download data: CEL

DataSet

Accession:: GDS2946

ID:: 2946

Select item 20012696314.

Prospective analyses of white adipose tissue gene expression in relation to long-term body weight changes

(Submitter supplied) The aim of this study was to investigate transcriptome signatures in human subcutaneous white adipose tissue (sWAT) before and after long-term weight changes and assess their predictive value for body weight change. Long-term body weight change in adult women associates with altered sWAT transcriptome. Expression of genes associated with inflammation, insulin response, adipogenesis and lipogenesis are linked to weight loss. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL23126
111 Samples

Download data: CEL

Series

Accession:: GSE126963

ID:: 200126963

Select item 20012177415.

RNA-sequencing analysis of paternal low-protein diet-induced gene expression change in mouse offspring adipocytes

(Submitter supplied) Increasing evidence indicates that parental diet affects the metabolism and health of offspring. It is reported that paternal low-protein diet (pLPD) induces glucose intolerance and the expression of genes involved in cholesterol biosynthesis in mouse offspring liver. The aim of the present study was to determine the effect of a pLPD on gene expression in offspring white adipose tissue (WAT), another important tissue for the regulation of metabolism. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
10 Samples

Download data: TXT

Series

Accession:: GSE121774

ID:: 200121774

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20010254016.

Meta- and cross-species analyses of insulin resistance based on gene expression datasets in human white adipose tissues

(Submitter supplied) Ample evidence indicates that insulin resistance (IR) is closely related to white adipose tissue (WAT), but the underlying mechanisms of IR pathogenesis are still unclear. Using 352 microarray datasets from seven independent studies, we identified a meta-signature which comprised of 1,413 genes. Our meta-signature was also enriched in overall WAT in in vitro and in vivo IR models. Only 12 core enrichment genes were consistently enriched across all IR models. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL16570
4 Samples

Download data: CEL

Series

Accession:: GSE102540

ID:: 200102540

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20013378617.

Whole transcriptome analysis of obese adipose tissue suggests u001kfc.1 as a potential regulator to glucose metabolism

(Submitter supplied) LncRNAs are newly proposed key factors controlling brown adipogenesis and development, but their regulatory effect to white adipocyte is still merely understood. Deciphering the underlying mechanism could be a novel way to discovering potential targets of obesity. In the present study, the whole transcriptome of adipose tissues collected from obese individuals and control subjects were analyzed by HTA2.0. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL17586
11 Samples

Download data: CEL

Series

Accession:: GSE133786

ID:: 200133786

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Select item 20006505818.

Altered DNA methylation of glycolytic and lipogenic genes in liver from obese and type 2 diabetic patients

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Methylation profiling by array; Expression profiling by array

Platforms:: GPL11532 GPL13534
45 Samples

Download data: CEL, IDAT

Series

Accession:: GSE65058

ID:: 200065058

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20006505719.

Altered DNA methylation of glycolytic and lipogenic genes in liver from obese and type 2 diabetic patients [methylome analysis]

(Submitter supplied) Type 2 diabetes is a complex disease associated with many underlying pathomechanisms. Epigenetic regulation of gene expression by DNA methylation has become increasingly recognized as an important component in the etiology of type 2 diabetes. We performed genome-wide methylome and transcriptome analysis in liver from severely obese patients with or without type 2 diabetes to discover aberrant pathways underlying the development of insulin resistance. more...