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Links from GEO DataSets

Items: 20

1.

CaSR modulator in neuroblastoma model [human]

(Submitter supplied) CaSR modulation inhibits neuroblastoma growth
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL17692
15 Samples
Download data: CEL
Series
Accession:
GSE73504
ID:
200073504
2.

CaSR modulator in neuroblastoma model

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus; Homo sapiens
Type:
Expression profiling by array
Platforms:
GPL17400 GPL17692
31 Samples
Download data: CEL
Series
Accession:
GSE73509
ID:
200073509
3.

CaSR modulator in neuroblastoma model [mouse]

(Submitter supplied) CaSR modulation inhibits neuroblastoma growth
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL17400
16 Samples
Download data: CEL
Series
Accession:
GSE73506
ID:
200073506
4.

AC-265347 inhibits neuroblastoma tumor growth by induction of differentiation without causing hypocalcemia

(Submitter supplied) Neuroblastoma is the most common extracranial solid childhood tumor with clinical manifestations ranging from benign tumors that spontaneously regress to highly aggressive metastatic disease. Unfortunately, there is no therapy known to be curative for high-risk neuroblastoma. The calcium-sensing receptor (CaSR) is a G protein-coupled receptor that senses plasmatic fluctuation in the extracellular concentration of calcium and plays a key role in maintaining calcium homeostasis. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL24324
24 Samples
Download data: CEL
Series
Accession:
GSE195577
ID:
200195577
5.

GRHL1 acts as a tumor suppressor in neuroblastoma and is negatively regulated by MYCN and HDAC3

(Submitter supplied) Neuroblastoma is an embryonic solid tumor of neural crest origin and accounts for 11% of all cancer-related deaths in children. Novel therapeutic strategies are therefore urgently required. MYCN oncogene amplification, which occurs in 20% of neuroblastomas, is a hallmark of high risk. Here we aimed to exploit molecular mechanisms that can be pharmacologically addressed with epigenetically modifying drugs, such as histone deacetylase (HDAC) inhibitors. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS5263
Platform:
GPL10558
12 Samples
Download data: TXT
Series
Accession:
GSE47407
ID:
200047407
6.
Full record GDS5263

Enforced Grainyhead-like 1 expression effect on BE(2)-C neuroblastoma cell line: time course

Analysis of BE(2)-C cells up to 72 hrs after transient transfection with construct pTRex-GRHL1. The three mammalian GRHL genes (GRHL1, -2, and -3) represent a highly conserved family of β-scaffold transcription factors. Results provide insight into the role of GRHL1 in neuroblastoma biology.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 protocol, 3 time sets
Platform:
GPL10558
Series:
GSE47407
12 Samples
Download data
DataSet
Accession:
GDS5263
ID:
5263
7.

Direct Targeting of MYCN Gene Amplification by Alkylating Pyrrole-Imidazole Polyamide and CRISPR/Cas9 in Neuroblastoma Cells (CHP-134)

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL17077
13 Samples
Download data: TXT
Series
Accession:
GSE121530
ID:
200121530
8.

Direct Targeting of MYCN Gene Amplification by CRISPR/Cas9 in Neuroblastoma Cells (CHP-134)

(Submitter supplied) Amplification of MYCN plays a pivotal role in multiple types of tumors and correlates with poor prognosis in high-risk neuroblastoma. Despite recent advances in the treatment of neuroblastoma, no approaches directly target the master oncogene MYCN. Difficulties in targeting the MYCN protein have inspired us to develop a new gene level inhibitory strategy using a sequence-specific gene regulator. Here we generated a MYCN-targeting pyrrole-imidazole (PI) polyamide, MYCN-A3, which directly binds to and alkylates DNA at homing motifs within MYCN transcript. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL17077
8 Samples
Download data: TXT
Series
Accession:
GSE121529
ID:
200121529
9.

Direct Targeting of MYCN Gene Amplification by Alkylating Pyrrole-Imidazole Polyamide in Neuroblastoma Cells (CHP-134)

(Submitter supplied) Amplification of MYCN plays a pivotal role in multiple types of tumors and correlates with poor prognosis in high-risk neuroblastoma. Despite recent advances in the treatment of neuroblastoma, no approaches directly target the master oncogene MYCN. Difficulties in targeting the MYCN protein have inspired us to develop a new gene level inhibitory strategy using a sequence-specific gene regulator. Here we generated a MYCN-targeting pyrrole-imidazole (PI) polyamide, MYCN-A3, which directly binds to and alkylates DNA at homing motifs within MYCN transcript. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL17077
5 Samples
Download data: TXT
Series
Accession:
GSE121528
ID:
200121528
10.

The long non-coding RNA GAS5 differentially regulates cell cycle arrest and apoptosis in human neuroblastoma

(Submitter supplied) Comparison of the global transcriptional profiles of the neurblastoma cell line IMR-32 48 hours after transfection with a Negative Control siRNA compared to an siRNA for the lncRNA GAS5.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18460
2 Samples
Download data: TXT
11.

Targeting EZH2 in MYCN-amplified Neuroblastoma

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL11154
24 Samples
Download data: BW
Series
Accession:
GSE85432
ID:
200085432
12.

Targeting EZH2 in MYCN-amplified Neuroblastoma [RNA-seq]

(Submitter supplied) Purpose: Identify new targets in MYCN-amplified Neuroblastoma Methods: Kelly and LAN-1 neuroblastoma cells were treated in duplicate with 2 uM GSK126 (Excess Biosciences M60071-2) or DMSO for 2 or 5 days. RNA was extracted from cells with the RNeasy Kit (Qiagen). RNA libraries were prepared for sequencing using standard Illumina protocols. The pool of sixteen samples was sequenced on two lanes of an Illumina HiSeq, generating single end reads of 32-76 bp length. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL11154
16 Samples
Download data: TXT
13.

Targeting EZH2 in MYCN-amplified Neuroblastoma [ChIP-seq]

(Submitter supplied) Purpose: Identify new targets in MYCN-amplified Neuroblastoma Methods: ChIP-Seq experiments were performed on Kelly and LAN-1 neuroblastoma cells by using the following antibodies: anti-EZH2 (Cell Signaling 5246S); anti-H3K27me3 (Millipore 07-449); anti-H3K4me3 (Abcam ab8580). We evaluated the global EZH2 PRC2-dependence by identifiying direct genome-wide target genes for EZH2, H3K27me3 and H3K4me3. more...
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL11154
8 Samples
Download data: BW
Series
Accession:
GSE85430
ID:
200085430
14.

Glutaminolysis fuels de novo glutathione synthesis, regulates redox homeostasis and directs T cell differentiation

(Submitter supplied) We reveal that dimethyl fumarate, a FDA approved drug (BG-12/Tecfidera) for multiple sclerosis, suppresses TH17 differentiation by augmenting intracellular ROS
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL23038
6 Samples
Download data: CEL
Series
Accession:
GSE98733
ID:
200098733
15.

MYCN drives glutaminolysis in neuroblastoma and confers sensitivity to ROS augmenting agents

(Submitter supplied) Through a small scale metabolic-modulator screening, we have identified dimethyl fumarate (DMF), a FDA approved drug for multiple sclerosis, which suppresses neuroblastoma cell growth in vitro and in vivo. Mechanistically, DMF suppresses neuroblastoma cell growth through inducing ROS and subsequently suppressing MYCN expression.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL16686
6 Samples
Download data: CEL
Series
Accession:
GSE98241
ID:
200098241
16.

MYCN induces neuroblastoma in primary neural crest cells

(Submitter supplied) Neuroblastoma (NBL) is an embryonal cancer of the sympathetic nervous system (SNS) that causes 15% of pediatric cancer deaths. High-risk neuroblastoma is characterized by N-Myc amplification and segmental chromosomal gains and losses. Due to limited disease models, the etiology of neuroblastoma is largely unknown, including both the cell of origin and the majority of oncogenic drivers. We have established a novel system for studying neuroblastoma based on the transformation of neural crest cells (NCCs), the progenitor cells of the SNS, isolated from mouse embryonic day 9.5 trunk neural tube explants. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL16570
8 Samples
Download data: CEL
Series
Accession:
GSE94914
ID:
200094914
17.

Effects of MYCN knockdwon on miRNA expression in neuroblastoma cells

(Submitter supplied) Global miRNAs expression profilling of SK-N-BE(2)-C cells after dsRNA-mediated knockdown of MYCN
Organism:
Homo sapiens
Type:
Non-coding RNA profiling by high throughput sequencing
Platform:
GPL11154
4 Samples
Download data: TXT
Series
Accession:
GSE72721
ID:
200072721
18.

Genome-wide mapping of MYCN binding in neuroblastoma cells

(Submitter supplied) To identify the MYCN transcription factor binding sites across the genome, we performed chromatin immunoprecipitation followed by sequencing (ChIP-seq) using anti-MYCN and anti-IgG antibodies on a MYCN-amplified NB cell line, SK-N-BE(2)-C.
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL11154
2 Samples
Download data: BED, TXT
Series
Accession:
GSE72640
ID:
200072640
19.

GAS7 Deficiency Promotes Metastasis of MYCN-driven Neuroblastoma

(Submitter supplied) Neuroblastoma (NB), the most common extracranial solid tumor in children, often metastasizes at a high rate. Here, we demonstrate that loss of function of the growth arrest-specific 7 gene (GAS7), located on Chr17p13.1, a deleted region in a subset of high-risk NB, accelerates dissemination of MYCN-overexpressing tumor cells in both zebrafish and xenografted mice models. Transcriptomic analysis of neuroblasotma tumors isolated from transgenic zebrafish overexpressing MYCN oncogene alone or MYCN with knockout of gas7 gene revealed that gene signitures affecting tumor cell-cell or cell-extracellular matrix interactions are significantly downregulated in tumors with gas7 loss of function. more...
Organism:
Danio rerio
Type:
Expression profiling by high throughput sequencing
Platform:
GPL14875
6 Samples
Download data: TXT
Series
Accession:
GSE131307
ID:
200131307
20.

Gene expression profiling of human neuroblastoma cell line LA1-55n expressing shGFP or shRNA to glycine decarboxylase (GLDC)

(Submitter supplied) Microarray gene expression profiling reveals that silencing GLDC expression downregulates genes required for DNA replication and cell cyle progression
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL16686
6 Samples
Download data: CEL
Series
Accession:
GSE129807
ID:
200129807
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