GEO DataSets

(Submitter supplied) High levels of oxidative stress and an associated neuronal DDR occur at the earliest stages of Alzheimer pathology (low Braak stage), and is associated with cognitive impairment. The aim of the present study was to combine immuno-LCM and microarray analysis to characterize the neuronal transcriptome at low Braak stages (Braak 0-II), with respect to the neuronal DDR, in post-mortem human frontal cortex derived from the Medical Research Council Cognitive Function and Ageing Study (MRC-CFAS).

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

8 Samples

Download data: CEL

(Submitter supplied) Type 2 diabetes mellitus (T2D), characterised by peripheral insulin resistance, is a risk factor for dementia. In addition to its contribution to small and large vessel disease, T2D may directly damage cells of the brain neurovascular unit. In this study, we investigated the transcriptomic changes in cortical neurones, and associated astrocytes and endothelial cells of the neurovascular unit, in the ageing brain

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

33 Samples

Download data: CEL

(Submitter supplied) Astrocyte dysfunction impacts their normal function, including neuronal support, thereby contributing to neurodegenerative pathologies including Alzheimer's disease (AD). Therefore to understand the role of astrocytes in the pathogenesis of age-related disorders we analysed the gene expression profile of astrocytes with respect to Alzheimer-type pathology. The aim of the present study was to combine immuno-LCM and microarray analysis to characterise the astrocyte transcriptome at different Braak stages, and with respect to ApoE genotype, in post-mortem human temporal cortex sampled dervied from the Medical Research Council Cognitive Function and Ageing Study (MRC-CFAS).

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS4135

Platform:

GPL570

18 Samples

Download data: CEL

Analysis of GFAP+ astrocytes representing different Braak stages and ApoE genotypes, in post-mortem temporal cortex samples. Astrocytes synthesize ApoE, which is involved in the astrocytic clearance of aggregated β-amyloid plaques. Results provide insight into role of ApoE in Alzheimer's pathology.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 3 disease state, 2 genotype/variation sets

Platform:

GPL570

Series:

GSE29652

18 Samples

Download data: CEL

(Submitter supplied) Comparison of the gene expression profiles of adult human brain samples from frontal cortical regions, including samples from young, middle aged, normal aged.

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS5204

Platform:

GPL570

41 Samples

Download data: CEL

Analysis of postmortem neuropathologically normal brain samples from the frontal cortical regions of young, middle aged, normal aged and extremely aged adults. Results provide insight into molecular mechanisms of aging in frontal cortical regions of the brain.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 4 age, 2 gender sets

Platform:

GPL570

Series:

GSE53890

41 Samples

Download data: CEL

(Submitter supplied) Neuronal cultures were treated with candesartan at neuroprotective concentrations followed by excitotoxic glutamate amounts. Candesartan significantly reduced glutamate-induced inflammation. To provide mechanistic insight into the potential targets and pathways that may underlie these benefits, we performed genome wide expression profile analysis and evaluated the data by Ingenuity Pathway Analysis (IPA) and Gene Set Enrichment Analysis (GSEA). more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL17117

16 Samples

Download data: CEL, CHP

(Submitter supplied) Alzheimer's disease (AD) is a devastating neurodegenerative disorder that threatens to reach epidemic proportions as our population ages. Although much research has examined molecular pathways associated with AD, relatively few studies have focused on critical early stages. Our prior microarray study correlated gene expression in human hippocampus with AD markers. Results suggested a new model of early-stage AD in which pathology spreads along myelinated axons, orchestrated by upregulated transcription and epigenetic factors related to growth and tumor suppression (Blalock et al., 2004). more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS4136

Platform:

GPL570

30 Samples

Download data: CEL

Analysis of laser-captured hippocampal CA1 gray matter from FFPE hippocampal sections of subjects at varying stages (incipient, moderate, severe) of Alzheimer’s disease (AD). Results provide insight into gray matter-specific molecular mechanisms underlying AD.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 19 age, 4 disease state sets

Platform:

GPL570

Series:

GSE28146

30 Samples

Download data: CEL

(Submitter supplied) Aging is the primary risk factor of neurodegenerative disorders such as Alzheimer's disease (AD). However, the molecular events occurring during brain aging are extremely complex and still largely unknown. For a better understanding of these age-associated modifications, animal models as close as possible to humans are needed. We thus analyzed the transcriptome of the temporal cortex of the primate Microcebus murinus using human oligonucleotide microarrays (Affymetrix). more...

Organism:

Microcebus murinus; Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS4128

Platform:

GPL570

18 Samples

Download data: CEL, CHP

Analysis of temporal cortex of young adult, old healthy, and Alzheimer’s disease (AD-like) animals. AD-like animals presented ß-amyloid plaques and cortical atrophy, which are signs of AD in humans. Results provided insight into molecular basis of physiological versus pathological brain aging.

Organism:

Homo sapiens; Microcebus murinus

Type:

Expression profiling by array, count, 2 age, 2 disease state, 2 gender sets

Platform:

GPL570

Series:

GSE21779

18 Samples

Download data: CEL, CHP

(Submitter supplied) Unravel the mechanisms underlying brain aging and Alzheimer´s disease (AD) has been difficult because of complexity of the networks that drive these aging-related changes. Analysis of the gene expression in the brain is a valuable tool to study the function of the brain under normal and pathological conditions. Gene microarray technology allows massively parallel analysis of most genes expressed in a tissue, and therefore is an important research tool that potentially can provide the investigative power needed to address the complexity of brain aging and neurodegenerative processes. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL1930

128 Samples

Download data

(Submitter supplied) Information about the genes that are preferentially expressed during the course of Alzheimer’s disease (AD) could improve our understanding of the molecular mechanisms involved in the pathogenesis of this common cause of cognitive impairment in older persons, provide new opportunities in the diagnosis, early detection, and tracking of this disorder, and provide novel targets for the discovery of interventions to treat and prevent this disorder. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

161 Samples

Download data: CEL, CHP, XLS

(Submitter supplied) Around 25% of stroke survivors over 65 years old develop progressive cognitive decline more than 3 months post-stroke, with features of vascular dementia. Poststroke dementia (PSD) is associated with pathology in frontal brain regions, in particular dorsal lateral prefrontal cortex (DLPFC) neurons and white matter, remote from the infarct, implicating damage to anterior cognitive circuits (ACC) involved in impaired executive function. more...

Organism:

Homo sapiens; Mus musculus

Type:

Expression profiling by array

Platforms:

GPL23038 GPL23159

100 Samples

Download data: CEL, CHP