Similar studies for GEO DataSets (Select 200060369) - GEO DataSets

Links from GEO DataSets

Items: 20

Select item 2000603691.

Myb permits multilineage airway epithelial cell differentiation

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by array

Platforms:: GPL17543 GPL19077
21 Samples

Download data: CSV, GPR

Series

Accession:: GSE60369

ID:: 200060369

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000603652.

Effects of Myb shRNA on Airway Epithelial Cells

(Submitter supplied) The epithelium of the pulmonary airway is specially differentiated to provide defense against environmental insults, but also subject to dysregulated differentiation that results in lung disease. The current paradigm for airway epithelial differentiation is a one-step program whereby a p63+ basal epithelial progenitor cell generates a ciliated or secretory cell lineage, but the cue for this transition and whether there are intermediate steps is poorly defined. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL17543
12 Samples

Download data: TXT

Series

Accession:: GSE60365

ID:: 200060365

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000603643.

Mouse Tracheal Epithelial Cell Air-Liquid Interface Primary Culture Time Course (ALI d0, d2, d7)

(Submitter supplied) Mouse tracheal epithelial cells were cultured at air-liquid interface (ALI), RNA was harvested at days 0, 2, and 7 post-ALI, and hybridized to two-channel MEEBO arrays. The experiment was designed to allow investigators to identify genes differentially expressed during airway epithelial cell differentiation and development, including ciliogenesis.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL19077
9 Samples

Download data: CSV, GPR

Series

Accession:: GSE60364

ID:: 200060364

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001196874.

Beta-catenin dependent gene expression

(Submitter supplied) Gene experssion was evaluated in the lungs of mice in which beta-catenin was stabilized or knocked out in the SCGB1A1 lineage. Gene expression was assayed on post-natal day 21

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6246
8 Samples

Download data: CEL

Series

Accession:: GSE119687

ID:: 200119687

Select item 2000764215.

JAG1 Mediated Notch Signaling Regulates Secretory Cell Differentiation of the Human Airway Epithelium

(Submitter supplied) Background: Basal cells (BC) are the stem/progenitor cells of the human airway epithelium capable of differentiating into secretory and ciliated cells. Notch signaling activation increases BC differentiation into secretory cells, but the role of individual Notch ligands in regulating this process is unknown Results: The objective of this study was to define the role of the Notch ligand JAG1 in regulating BC differentiation. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
8 Samples

Download data: CSV

Series

Accession:: GSE76421

ID:: 200076421

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 2001242656.

Characterization of an Immortalized Human Small Airway Basal Stem/Progenitor Cell Line with Airway Region-specific Differentiation Capacity

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Expression profiling by high throughput sequencing

Platforms:: GPL570 GPL16791
30 Samples

Download data: CEL

Series

Accession:: GSE124265

ID:: 200124265

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001242587.

Characterization of an Immortalized Human Small Airway Basal Stem/Progenitor Cell Line with Airway Region-specific Differentiation Capacity [RNA-Seq]

(Submitter supplied) The pathology of chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis and the majority of lung cancers involve the small airway epithelium (SAE), the single continuous layer of cells lining the airways ≥6th generations. The basal cells (BC) are the stem/progenitor cells of the SAE, responsible for the differentiation into intermediate cells and ciliated, club and mucous differentiated cells. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
2 Samples

Download data: CSV

Series

Accession:: GSE124258

ID:: 200124258

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001242538.

Characterization of an Immortalized Human Small Airway Basal Stem/Progenitor Cell Line with Airway Region-specific Differentiation Capacity [array]

(Submitter supplied) The pathology of chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis and the majority of lung cancers involve the small airway epithelium (SAE), the single continuous layer of cells lining the airways ?6th generations. The basal cells (BC) are the stem/progenitor cells of the SAE, responsible for the differentiation into intermediate cells and ciliated, club and mucous differentiated cells. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
28 Samples

Download data: CEL

Series

Accession:: GSE124253

ID:: 200124253

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000243379.

The Human Airway Epithelial Basal Cell Transcriptome

(Submitter supplied) Background. The human airway epithelium consists of 4 major cell types: ciliated, secretory, columnar and basal cells. During natural turnover and in response to injury, the airway basal cells function as stem / progenitor cells for the other airway cell types. The objective of this study is to better understand basal cell biology by defining the subset of expressed genes that characterize the signature of human airway epithelial basal cells. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
17 Samples

Download data: CEL, CHP

Series

Accession:: GSE24337

ID:: 200024337

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20021866310.

Repair of airway epithelia requires metabolic rewiring towards fatty acid oxidation

(Submitter supplied) Repair of airway epithelia requires metabolic rewiring towards fatty acid oxidation

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
9 Samples

Download data: RESULTS

Series

Accession:: GSE218663

ID:: 200218663

PubMed Full text in PMC Similar studies

Select item 20020968611.

Repair of airway epithelia requires metabolic rewiring towards fatty acid oxidation

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21103
27 Samples

Download data

Series

Accession:: GSE209686

ID:: 200209686

PubMed Full text in PMC Similar studies

Select item 20020968412.

Repair of airway epithelia requires metabolic rewiring towards fatty acid oxidation [II]

(Submitter supplied) To test the role of FAO in epithelium differentiation, we assessed genome-wide transcriptional changes in Cpt1a+/- and Cpt1a-/- primary mouse tracheal epithelial cell (mTEC) cultures analysed at the end of the expansion phase (ALI day 0) or at day 5 and 7 post air-exposure by RNA-seq.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21103
18 Samples

Download data: TXT

Series

Accession:: GSE209684

ID:: 200209684

PubMed Full text in PMC Similar studies

Select item 20020967813.

Repair of airway epithelia requires metabolic rewiring towards fatty acid oxidation [I]

(Submitter supplied) Comparative gene expression profiling analysis of RNA-seq data from CD49f+NGFR+, CD49f-NGFR- cell sorted from differentiated MTEC cultures collected at ALI day 10, and MTEC culture taken at ALI t0

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21103
9 Samples

Download data: TXT

Series

Accession:: GSE209678

ID:: 200209678

PubMed Full text in PMC Similar studies

Select item 20006900514.

Rapid expansion of human epithelial stem cells suitable for airway tissue engineering

(Submitter supplied) Rationale: Stem cell-based tracheal replacement represents an emerging therapeutic option for patients with otherwise untreatable airway diseases including long-segment congenital tracheal stenosis and upper airway tumors. Clinical experience suggests an urgent need to restore mucociliary function in the lungs following transplantation of tissue-engineered grafts, while pre-clinical studies show that seeding scaffolds with autologous mucosa improves regeneration. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10558
8 Samples

Download data: TXT

Series

Accession:: GSE69005

ID:: 200069005

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20006905815.

Gene expression data from mouse tracheal cells before and 48hrs after SO2 injury

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
12 Samples

Download data: CEL

Series

Accession:: GSE69058

ID:: 200069058

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20006905716.

Gene expression data from mouse tracheal mesenchymal cells before and 48hrs after SO2 injury

(Submitter supplied) The conducting airway epithelium of the rodent and human lung is underlaid by mesenchymal cells that include vasculature, smooth muscle, fibroblasts and cartilage. The goal of this project is to identify cellular and molecular changes in the mesenchyme after injury to the epithelium by exposure to SO2 and which may participate in repair of the epithelium We used Affymetrix microarray analysis to compare transcripts in tracheal mesenchyme before and after SO2 injury.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
6 Samples

Download data: CEL

Series

Accession:: GSE69057

ID:: 200069057

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20006905617.

Gene expression data from mouse tracheal epithelial cells isolated before and 48hrs after SO2 injury

(Submitter supplied) The conducting airway epithelium of the rodent and human lung is made up of about equal proportions of ciliated and secretory cells. In addition, in regions where the epithelium is pseudostratfied, ~30% of the epithelium consists of undifferentiated basal cells (BCs). Evidence suggests that these BCs are multipotent stem cells that can self renew over the long term and give rise to both ciliated and secretory lineages. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
6 Samples

Download data: CEL

Series

Accession:: GSE69056

ID:: 200069056

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20002194318.

MYB silencing in CD14-myeloblasts

(Submitter supplied) The c-Myb transcription factor is highly expressed in immature hematopoietic cells and down-regulated during differentiation. To define the role of c-Myb during the terminal differentiation of hematopoietic precursors, we studied the effects of its silencing in human primary CD14-myeloblasts, which maintain a granulo-monocyte differentiation bipotentiality. c-Myb-silenced myeloblasts were blocked in the G1 phase of the cell cycle at 24 hours post-nucleofection and subsequently were forced towards macrophage differentiation, as demonstrated by immunophenotypic and morphological analysis. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL96
3 Samples

Download data: CEL, CHP

Series

Accession:: GSE21943

ID:: 200021943

Select item 20001311019.

MYB silencing in CD34+ progenitor cells

(Submitter supplied) The c-Myb transcription factor is highly expressed in immature hematopoietic cells and down-regulated during differentiation. To define the role of c-Myb in human hematopoietic lineage commitment, we studied the effects of its silencing during the commitment of human CD34+ Hematopoietic stem/progenitor cells. In CD34+ cells c-Myb silencing determined a cell cycle arrest in G0/G1 phase which strongly decreased the clonogenic efficiency, togheter with a reduction of erythroid colonies coupled with an increase of the macrophage and megakaryocyte ones. more...