Similar studies for GEO DataSets (Select 200031086) - GEO DataSets

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Items: 20

Select item 2000310861.

Expression data from Bmi1-null common myeloid progenitor (CMP)

(Submitter supplied) Bmi1 is a component of polycomb repressive complex 1 and its role in the inheritance of the stemness of adult somatic stem cells has been well characterized. Bmi1 maintains the self-renewal capacity of adult stem cells, at least partially, by repressing the Ink4a/Arf locus that encodes a cyclin-dependent kinase inhibitor, p16Ink4a, and a tumor suppressor, p19Arf 14. Deletion of both Ink4a and Arf in Bmi1-deficient mice substantially restored the defective self-renewal capacity of HSCs and neural stem cells.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
6 Samples

Download data: CEL, CHP

Series

Accession:: GSE31086

ID:: 200031086

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000197962.

Expression data from Bmi1-null c-Kit+Sca-1+Lineage marker- (KSL) hematopoietic stem/progenitor cells

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
7 Samples

Download data: CEL, CHP

Series

Accession:: GSE19796

ID:: 200019796

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000209583.

Polycomb Group Protein Bmi1 Promotes Hematopoietic Cell Development from ES Cells

(Submitter supplied) Bmi1 is a component of the Polycomb-repressive complexes (PRC) and essential for maintaining the pool of adult stem cells. PRC are key regulators for embryonic development by modifying chromatin architecture and maintaining gene repression. To assess the role of Bmi1 in pluripotent stem cells and upon exit from pluripotency during differentiation, we studied forced Bmi1 expression in mouse embryonic stem cells (ESC). more...

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS4211
Platform:: GPL1261
8 Samples

Download data: CEL

Series

Accession:: GSE20958

ID:: 200020958

Select item 42114.

Polycomb repressive complex 1 protein Bmi1 transduced CCE embryonic stem cells and differentiated embryoid body samples

Analysis of Bmi1 transduced CCE embryonic stem cells (ESC) and CCE ESC differentiated by embryoid body assay. Bmi1 is essential for maintaining the pool of adult stem cells. Results provide insight into role of Bmi1 in ESC-derived hematopoietic cell transition from pluripotency to differentiation.

Organism:: Mus musculus

Type:: Expression profiling by array, transformed count, 5 genotype/variation sets

Platform:: GPL1261
Series:: GSE20958
8 Samples

Download data: CEL

DataSet

Accession:: GDS4211

ID:: 4211

Select item 2000314045.

Expression profiling of LSK cells from Bmi1 cKO mice in hematopoiesis versus LSK control cells from WT mice

(Submitter supplied) Bmi1 is a protein member of PRC1 and plays a major role in the maintenance of gene repression. We are studying the role of Bmi1 in the context of hematopoietic stem cell aging. We used microarray to study the gene expression profile of LSK cells in relation to the knocking-out of Bmi1 in vivo

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL10787
5 Samples

Download data: PDF, TXT, XLS

Series

Accession:: GSE31404

ID:: 200031404

Select item 2000329296.

Expression data from Ezh2-null erythrocyte/megakaryocyte progenitor (MEP)

(Submitter supplied) The polycomb group (PcG) proteins function in gene silencing through histone modifications. They form chromatin-associated multiprotein complexes, termed polycomb repressive complex (PRC) 1 and PRC2. These two complexes work in a coordinated manner in the maintenance of cellular memories through transcriptional repression of target genes. EZH2 is a catalytic component of PRC2 and trimethylates histone H3 at lysine 27 to transcriptionally repress the target genes. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL10333
4 Samples

Download data: TXT

Series

Accession:: GSE32929

ID:: 200032929

Select item 2000695007.

Understanding the role of EZH2 insufficiency in the pathogenesis of PMF

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL10787
12 Samples

Download data: TXT

Series

Accession:: GSE69500

ID:: 200069500

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000694998.

Expression data from Lineage-c-Kit+Sca-1+ (LSK) and megakaryocyte/erythroid progenitor (MEP) cells isolated from JAK2V617F/Ezh2Δ/Δ mice post JQ1 treatment

(Submitter supplied) Loss-of-function mutations in EZH2 are associated with worse outcomes in patients with primary myelofibrosis (PMF). To understand how EZH2 insufficiency is involved in the pathogenesis of PMF, we generated mice compound for Ezh2 conditional deletion and a JAK2V617F transgene.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL10787
4 Samples

Download data: TXT

Series

Accession:: GSE69499

ID:: 200069499

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000694989.

Expression data from Lineage-c-Kit+Sca-1+ (LSK) and megakaryocyte/erythroid progenitor (MEP) cells isolated from WT, Ezh2Δ/Δ, JAK2V617F, and JAK2V617F/Ezh2Δ/Δ mice

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL10787
8 Samples

Download data: TXT

Series

Accession:: GSE69498

ID:: 200069498

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20008525010.

Gene expression profile (GEP) of CD34+ cells overexpressing miR-494-3p

(Submitter supplied) As recently reported by our group, we performed miRNA and gene expression profiling of CD34+ hematopoietic stem/progenitor cells (HSPCs) isolated from 42 PMF patient samples compared with 31 healthy controls. Integrative analysis of these profiles by means of Ingenuity Pathway Analysis (IPA) allowed the identification of several aberrantly regulated miRNA-mRNA target pairs organized in interaction networks. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL13667
6 Samples

Download data: CEL

Series

Accession:: GSE85250

ID:: 200085250

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20005348211.

Integrative Analysis of Gene and miRNA expression profiles in Primary Myelofibrosis CD34+ cells

(Submitter supplied) Ph-negative myeloproliferative neoplasms (MPNs) are characterized by many somatic mutations which have already been shown useful in the prognostic assessment of MPN patients. Moreover, aberrant microRNA (miRNA) expression seems to add to the molecular complexity of MPNs, as specific miRNA signatures capable of discriminating MPN cells from those of normal donors were previously reported. In order to have a comprehensive picture of miRNA deregulation and its relationship with differential gene expression in primary myelofibrosis (PMF) cells, we obtained gene- (GEP) and miRNA expression profiles (miEP) of CD34+ cells from 31 healthy donors and 42 PMF patients using Affymetrix technology (HG-U219 and miRNA 2.0 arrays). more...

Organism:: synthetic construct; Homo sapiens

Type:: Expression profiling by array; Non-coding RNA profiling by array

Platforms:: GPL14613 GPL13667
146 Samples

Download data: CEL, TXT

Series

Accession:: GSE53482

ID:: 200053482

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20004181212.

Gene expression profile of mutated and wild-type PMF CD34+ cells

(Submitter supplied) Primary mielofibrosis (PMF) is a rare chronic myeloproliferative disorder characterized by the accumulation of abnormal megakaryocytes (Mks) in the bone marrow (BM), variable degrees of BM fibrosis, osteosclerosis and angiogenesis, immature myeloid and erythroid cells, and tear-drop erythrocytes in the peripheral blood (PB), and extramedullary hematopoiesis. The identification of the JAK2V617F mutation represented a seminal discovery in the field of Philadelphia-chromosome–negative chronic myeloproliferative neoplasms (MPNs), providing clues to the pathogenesis, prompting a revision of the diagnostic criteria, and culminating in the development of clinical trials with JAK2 (and JAK1) inhibitors. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL13667
20 Samples

Download data: CEL

Series

Accession:: GSE41812

ID:: 200041812

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20004266613.

Expression data from Tet2-hypomorph (knockdown) and/or Ezh2-null Lineage-Sca-1+c-Kit+ (LSK) cells and granulocyte-macrophage progenitors (GMPs)

(Submitter supplied) PcG proteins form the polycomb repressive complexes (PRC) 1 and 2, functioning as transcriptional repressors through histone modifications. They have been implicated in the maintenance of self-renewing somatic and cancer stem cells. PcG genes have been characterized as tumor suppressor genes as exemplified by somatic inactivating mutations of EZH2, a gene encoding histone methyltransferase in PRC2, in myeloid malignancy. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL13912
12 Samples

Download data: TXT

Series

Accession:: GSE42666

ID:: 200042666

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20002140414.

Opposing roles of polycomb repressive complexes in hematopoietic stem and progenitor cells

(Submitter supplied) Polycomb group (PcG) proteins are transcriptional repressors with a central role in the establishment and maintenance of gene expression patterns during development. We have investigated the role of Polycomb Repressive Complexes (PRCs) in hematopoietic stem cells (HSCs) and progenitor populations. We show that mice with loss of function mutations in PRC2 components display enhanced HSC/progenitor population activity, whereas mutations that disrupt PRC1 or PhoRC are associated with HSC/progenitor cell defects. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6887
18 Samples

Download data: TXT

Series

Accession:: GSE21404

ID:: 200021404

Select item 20003366015.

Direct Recruitment of Polycomb Repressive Complex 1 (PRC1) to Chromatin by Core Binding Transcription Factors

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL11002 GPL1261 GPL13112
27 Samples

Download data: BED, CEL

Series

Accession:: GSE33660

ID:: 200033660

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20003365916.

Direct Recruitment of Polycomb Repressive Complex 1 (PRC1) to Chromatin by Core Binding Transcription Factors (microarray)

(Submitter supplied) Polycomb repressive complexes (PRCs) play key roles in developmental epigenetic regulation. Yet the mechanisms that target PRCs to specific loci in mammalian cells remain incompletely understood. In this study, we show that Bmi1, a core component of Polycomb Repressive Complex 1 (PRC1), binds directly to the Runx1/CBFbeta transcription factor complex. Genome-wide studies in megakaryocytic cells demonstrate considerable chromatin occupancy overlap between the PRC1 core component Ring1b and Runx1/CBFbeta and functional regulation of a significant fraction of commonly bound genes. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
9 Samples

Download data: CEL

Series

Accession:: GSE33659

ID:: 200033659

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20003365317.

Direct Recruitment of Polycomb Repressive Complex 1 (PRC1) to Chromatin by Core Binding Transcription Factors (ChIP-Seq)

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL11002 GPL13112
18 Samples

Download data: BED

Series

Accession:: GSE33653

ID:: 200033653

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20001590918.

Gene expression and UH2A ChIP-Seq binding analysis in Bmi1 knock-out and wild type MEFs

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL9185 GPL1261
4 Samples

Download data: BED, CEL, CHP, TXT

Series

Accession:: GSE15909

ID:: 200015909

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20001589619.

Genome wide uH2A localization analysis highlights Bmi1-dependent deposition of the mark at repressed genes.

(Submitter supplied) Polycomb group (PcG) proteins control organism development by regulating the expression of developmental genes. Transcriptional regulation by PcG proteins is achieved at least partly through the PRC2-mediated methylation on lysine 27 of histone H3 (H3K27) and PRC1-mediated ubiquitylation on lysine 119 of histone H2A (uH2A). As an integral component of PRC1, Bmi1 has been demonstrated to be critical for H2A ubiquitylation. more...