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Links from GEO DataSets

Items: 6

1.

Cultured OEC versus cultured SC and versus native OEC

(Submitter supplied) This microarray study aimed at identifying the differences in the global gene expression growth program of adult cultured olfactory ensheathing cells (cOEC) (from the olfactory bulb) versus adult cultured Schwann cells (SC) (from the sciatic nerve) and versus adult OEC directly dissected from the olfactory nerve layer (nOEC). The aim of the comparison between cOEC and SC is to define intrinsic molecular differences that distinguish cOEC from SC (both cell types support neuronal regeneration). more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL890
9 Samples
Download data: TXT
Series
Accession:
GSE24801
ID:
200024801
2.

TRNP1 regulates expansion and folding of the mammalian cerebral cortex by control of radial glial fate

(Submitter supplied) Evolution of the mammalian brain encompassed a remarkable increase in size of cerebral cortex, including tangential and radial expansion, but the mechanisms underlying these key parameters are still largely unknown. Here, we identified the novel DNA associated protein TRNP1 as a regulator of cerebral cortical expansion in both these dimensions. Gain and loss of function experiments in the mouse cerebral cortex in vivo demonstrate that high Trnp1 levels promote neural stem cell self-renewal and tangential expansion, while lower levels promote radial expansion resulting in a potent increase in the generation of intermediate progenitors and outer radial glial cells resulting in folding of the otherwise smooth murine cerebral cortex. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
7 Samples
Download data: CEL
Series
Accession:
GSE40582
ID:
200040582
3.

Prospective isolation of functionally distinct radial glial subtypes - lineage and transcriptome analysis

(Submitter supplied) Since the discovery of radial glia as the source of neurons, their heterogeneity in regard to neurogenesis has been described by clonal and time-lapse analysis in vitro. However, the molecular determinants specifying neurogenic radial glia differently from radial glia that mostly self-renew remain ill-defined. Here, we isolated two radial glial subsets that co-exist at mid-neurogenesis in the developing cerebral cortex and their immediate progeny. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
17 Samples
Download data: CEL, CHP
Series
Accession:
GSE8034
ID:
200008034
4.

FVB nerve x SC comparison

(Submitter supplied) wild-type mouse (FVB strain) expression profiles of adult sciatic nerve and of cultured Schwann cell Keywords: other
Organism:
Mus musculus
Type:
Expression profiling by SAGE
Platform:
GPL11
2 Samples
Download data
Series
Accession:
GSE2530
ID:
200002530
5.

Characterization of boundary cap cells using novel markers obtained by RNA profiling

(Submitter supplied) Neural crest (NC) cells are a multipotent, highly migratory cell population that generates most of the components of the peripheral nervous system (PNS), including the glial satellite and Schwann cells. In addition, NC cells also gives rise to another type of PNS glial cell, the boundary cap (BC) cells. These latter cells are located at the interface between central nervous system and PNS, at the exit/entry points of ventral motor and dorsal sensory axons. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL7017
8 Samples
Download data: GPR
Series
Accession:
GSE11979
ID:
200011979
6.

Insights into olfactory ensheathing cell development from a laser-microdissection and transcriptome-profiling approach

(Submitter supplied) Olfactory ensheathing cells (OECs) are neural crest-derived glia that ensheath bundles of olfactory axons from their peripheral origins in the olfactory epithelium to their central targets in the olfactory bulb. We took an unbiased laser microdissection and differential RNA-seq approach, validated by in situ hybridisation, to identify candidate molecular mechanisms underlying mouse OEC development and differences with the neural crest-derived Schwann cells developing on other peripheral nerves. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL19057
31 Samples
Download data: TXT, XLSX
Series
Accession:
GSE138596
ID:
200138596
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Supplemental Content

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