GEO DataSets

(Submitter supplied) Advances in genomic signatures have begun to dissect breast cancer heterogeneity, and application of these signatures will allow the prediction of which pathways are important in tumor development. Here we used genomic signatures to predict involvement of specific E2F transcription factors in Myc-induced tumors. We genetically tested this prediction by interbreeding Myc transgenics with mice lacking various activator E2F alleles. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS4094

Platform:

GPL8321

80 Samples

Download data: CEL, CHP

Analysis of MMTV-Myc tumors generated in an E2F wild-type, E2F1 null, E2F2 null or E2F3 heterozygous background. E2Fs are Myc transcriptional activators shown to regulate proliferation and apoptosis. Results provide insight into role of E2Fs in Myc-induced breast cancer.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 4 genotype/variation sets

Platform:

GPL8321

Series:

GSE24594

80 Samples

Download data: CEL, CHP

(Submitter supplied) previously published mouse data Pubmed IDS: 12754511, 12839964 Keywords: disease state analysis

Organism:

Mus musculus

Type:

Expression profiling by array

Platforms:

GPL75 GPL76

56 Samples

Download data

(Submitter supplied) HER2 / Neu is amplified and overexpressed in a large proportion of human breast cancers, but the signaling pathways that contribute to tumor development and metastatic progression are not completely understood. Using gene expression data and pathway signatures we predicted a role for activator E2F transcription factors in Neu induced tumors. This was genetically tested by interbreeding Neu transgenics with knockouts of the three activator E2Fs. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL8321

60 Samples

Download data: CEL

(Submitter supplied) Deregulated expression of the Myc transcription factor is a frequent causal mutation in human cancer. Thousands of putative Myc target genes have been identified in in vitro studies, indicating that Myc exerts highly pleiotropic effects within cells and tissues. However, the complexity and diversity of Myc gene targets has confounded attempts at identifying which of these genes are the critical targets mediating Myc-driven tumorigenesis in vivo. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS2025

Platform:

GPL81

27 Samples

Download data: CEL

Analysis of transgenic pancreatic islet beta cells after activation of Myc for up to 24 hours or activation for 21 days followed by deactivation for up to 6 days. Results provide insight into the molecular basis of Myc-driven tumorigenesis in vivo.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 other, 9 protocol sets

Platform:

GPL81

Series:

GSE4356

27 Samples

Download data: CEL

(Submitter supplied) We used microarrays to compare gene expression profiles between mouse mammary tumors initiated by Myc to those that have escaped Myc oncogene dependence.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL8321

75 Samples

Download data: CEL

(Submitter supplied) We have compared an involution timecourse for wild type and E2F3 heterozygous mice on the Operon 3.0 platform. Three mice were taken for each genotype at each timepoint (Involution day 0, 1, 2, 3 and 4) and RNA was prepared from the mammary glands. The RNA from each mouse was pooled and run as an individual sample. Keywords: Mouse Mammary Gland RNA

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL3222

30 Samples

Download data: GPR, TXT

(Submitter supplied) We have used primary MEFs derived from wild type and E2F4 null mice growing asynchrounously in serum to generate a signature for E2F4 pathway activation. 10 wild type and 10 E2F4 null samples were each assayed using the Affymetrics Mouse Genome 430A 2.0 array. Keywords: Primary MEFs from wild type and E2F4 null mice

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL8321

20 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array; Expression profiling by high throughput sequencing

Platforms:

GPL11154 GPL16043

8 Samples

Download data: CEL, TXT

(Submitter supplied) Gene expression analysis is a widely used and powerful method for investigating the transcriptional behavior of biological systems, for classifying cell states in disease and for many other purposes. Recent studies indicate that common assumptions currently embedded in experimental and analytical practices can lead to misinterpretation of global gene expression data. We discuss these assumptions and describe solutions that should minimize erroneous interpretation of gene expression data from multiple analysis platforms.

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL11154

2 Samples

Download data: TXT

(Submitter supplied) Gene expression analysis is a widely used and powerful method for investigating the transcriptional behavior of biological systems, for classifying cell states in disease and for many other purposes. Recent studies indicate that common assumptions currently embedded in experimental and analytical practices can lead to misinterpretation of global gene expression data. We discuss these assumptions and describe solutions that should minimize erroneous interpretation of gene expression data from multiple analysis platforms.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL16043

6 Samples

Download data: CEL