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Links from GEO DataSets

Items: 20

1.

Microarray analysis of expression of cell death-associated genes in rat spinal cord cells exposed to cyclic tensile stresses in vitro

(Submitter supplied) The application of mechanical insults to the spinal cord results in profound cellular and molecular changes, including the induction of neuronal cell death and altered gene expression profiles. We demonstrated that spinal cord cells undergo cell death in response to cyclic tensile stresses, which were dose- and time- dependent. In addition, we have identified the up regulation of various genes, in particular of the MAPK pathway, which may be involved in this cellular response. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL1355
7 Samples
Download data: CEL, CHP
Series
Accession:
GSE22791
ID:
200022791
2.

Gene expression changes under cyclic mechanical stretch in rat retinal Muller cells

(Submitter supplied) The retina is often subjected to tractional forces in a variety of conditions, for instance, pathological myopia, proliferative vitreoretinopathy. As the predominant glial element in the sensory retina, Muller cells are responsible for the homeostatic and metabolic support of retinal neurons and active players in virtually all forms of retinal injury and disease. Besides, Muller cells span the entire retinal thickness, extending from the inner to the outer limiting membranes, with cell bodies located in the inner nuclear layer and lateral processes expanding into the plexiform layers of the tissue. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL1355
12 Samples
Download data: CEL, CHP
Series
Accession:
GSE43516
ID:
200043516
3.

Tissue Factor Pathway Inhibitor-2 is Induced by Fluid Shear Stress in Vascular Smooth Muscle

(Submitter supplied) Tissue Factor Pathway Inhibitor-2 is Induced by Fluid Shear Stress in Vascular Smooth Muscle Cells and Affects Cell Proliferation and Survival Introduction: Vascular smooth muscle cells (SMCs) are exposed to fluid shear stress (FSS) after interventional procedures such as balloon-angioplasty. Whereas the effects of hemodynamic forces on endothelial cells are explored in detail, the influence of FSS on smooth muscle cell function is poorly characterized. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL1355
6 Samples
Download data: CEL
Series
Accession:
GSE19909
ID:
200019909
4.

CNS Regeneration

(Submitter supplied) Summary: Spinal cord injury (SCI) is a damage to the spinal cord induced by trauma or desease resulting in a loss of mobility or feeling. SCI is characterized by a primary mechanical injury followed by a secondary injury in which several molecular events are altered in the spinal cord often resulting in loss of neuronal function. Hypothesis: Spinal cord injury (SCI) induces a cascade of molecular events including the activation of genes associated with transcription factors, inflammation, oxidative stress, ionic imbalance, apoptosis and neuroregeneration which suggests the existance of endogenous reparative attempts. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Datasets:
GDS63 GDS259 GDS339 GDS869 GDS870 GDS871 GDS872 GDS873 GDS874
Platforms:
GPL86 GPL85 GPL87
544 Samples
Download data: CEL
Series
Accession:
GSE464
ID:
200000464
5.
Full record GDS874

Spinal cord injury and regeneration time course: above T9 (RG-U34C)

Temporal analysis of molecular mechanisms of spinal cord degeneration and repair. Analyzed spinal cord above thoracic vertebrae T9 at various time points up to 28 days post injury. Mild and severe injury examined.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, count, 3 protocol, 7 time sets
Platform:
GPL87
Series:
GSE464
48 Samples
Download data: CEL
DataSet
Accession:
GDS874
ID:
874
6.
Full record GDS873

Spinal cord injury and regeneration time course: above T9 (RG-U34B)

Temporal analysis of molecular mechanisms of spinal cord degeneration and repair. Analyzed spinal cord above thoracic vertebrae T9 at various time points up to 28 days post injury. Mild and severe injury examined.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, count, 3 protocol, 7 time sets
Platform:
GPL86
Series:
GSE464
47 Samples
Download data: CEL
DataSet
Accession:
GDS873
ID:
873
7.
Full record GDS872

Spinal cord injury and regeneration time course: above T9 (RG-U34A)

Temporal analysis of molecular mechanisms of spinal cord degeneration and repair. Analyzed spinal cord above thoracic vertebrae T9 at various time points up to 28 days post injury. Mild, moderate and severe injury examined.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, count, 4 protocol, 7 time sets
Platform:
GPL85
Series:
GSE464
52 Samples
Download data: CEL
DataSet
Accession:
GDS872
ID:
872
8.
Full record GDS871

Spinal cord injury and regeneration time course: below T9 (RG-U34C)

Temporal analysis of molecular mechanisms of spinal cord degeneration and repair. Analyzed spinal cord below thoracic vertebrae T9 at various time points up to 28 days post injury. Mild and severe injury examined.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, count, 3 protocol, 6 time sets
Platform:
GPL87
Series:
GSE464
43 Samples
Download data: CEL
DataSet
Accession:
GDS871
ID:
871
9.
Full record GDS870

Spinal cord injury and regeneration time course: below T9 (RG-U34B)

Temporal analysis of molecular mechanisms of spinal cord degeneration and repair. Analyzed spinal cord below thoracic vertebrae T9 at various time points up to 28 days post injury. Mild and severe injury examined.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, count, 3 protocol, 7 time sets
Platform:
GPL86
Series:
GSE464
52 Samples
Download data: CEL
DataSet
Accession:
GDS870
ID:
870
10.
Full record GDS869

Spinal cord injury and regeneration time course: below T9 (RG-U34A)

Temporal analysis of molecular mechanisms of spinal cord degeneration and repair. Analyzed spinal cord below thoracic vertebrae T9 at various time points up to 28 days post injury. Mild, moderate and severe injury examined.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, count, 4 protocol, 7 time sets
Platform:
GPL85
Series:
GSE464
55 Samples
Download data: CEL
DataSet
Accession:
GDS869
ID:
869
11.
Full record GDS339

Spinal cord injury and regeneration time course: at T9 (RG-U34C)

Temporal analysis of molecular mechanisms of spinal cord degeneration and repair. Analyzed spinal cord at thoracic vertebrae T9 at various time points up to 28 days post injury. Mild, moderate and severe injury examined.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, count, 4 protocol, 11 time sets
Platform:
GPL87
Series:
GSE464
75 Samples
Download data: CEL
DataSet
Accession:
GDS339
ID:
339
12.
Full record GDS259

Spinal cord injury and regeneration time course: at T9 (RG-U34B)

Temporal analysis of molecular mechanisms of spinal cord degeneration and repair. Analyzed spinal cord at thoracic vertebrae T9 at various time points up to 28 days post injury. Mild, moderate and severe injury examined.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, count, 4 protocol, 11 time sets
Platform:
GPL86
Series:
GSE464
77 Samples
Download data: CEL
DataSet
Accession:
GDS259
ID:
259
13.
Full record GDS63

Spinal cord injury and regeneration time course: at T9 (RG-U34A)

Temporal analysis of molecular mechanisms of spinal cord degeneration and repair. Analyzed spinal cord at thoracic vertebrae T9 at various time points up to 28 days post injury. Mild, moderate and severe injury examined.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, count, 4 protocol, 11 time sets
Platform:
GPL85
Series:
GSE464
89 Samples
Download data: CEL
DataSet
Accession:
GDS63
ID:
63
14.

Influence of cyclical mechanical strain on global gene expression in human lamina cribrosa cells in vitro

(Submitter supplied) The mechanical effect of raised intraocular pressure is a recognised stimulus for optic neuropathy in primary open angle glaucoma (POAG). Characteristic extra-cellular matrix (ECM) remodelling accompanies axonal damage in the lamina cribrosa (LC) of the optic nerve head in POAG. Glial cells in the lamina cribrosa may play a role in this process but the precise cellular responses to mechanical forces in this region are unknown. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL96
2 Samples
Download data
Series
Accession:
GSE3166
ID:
200003166
15.

Development of gene expression for stress in heat- and shake-induced injury in the rat jejunum

(Submitter supplied) To further development of our gene expression approach to biodosimetry, we have employed whole genome microarray expression profiling as a discovery platform to identify genes with the potential to distinguish radiation dose across an exposure range relevant for medical decision-making in a radiological emergency. Human peripheral blood from healthy donors was irradiated ex vivo, and a 74-gene consensus signature was identified that distinguished between four radiation doses (0.5, 2, 5 and 8 Gy) and control samples. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL7294
6 Samples
Download data: TXT
Series
Accession:
GSE61498
ID:
200061498
16.

Anti-inflammatory compounds in SCI

(Submitter supplied) A screen of 5 anti-inflammatory compounds for their effects in explanted, cultured rat spinal cord slices. All injured (explanted) cords are cultured for 4 hrs. Keywords: ordered
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL479
21 Samples
Download data
Series
Accession:
GSE633
ID:
200000633
17.

Gene expression profiles of two distinct neuronal populations in the neonatal rat spinal cord

(Submitter supplied) Here we compare the gene expression profiles of two distict, fluorescently identified neuronal populations, the motor neruons (MN) and the decending commissural interneurons (dCIN) of the neonatal rat spinal cord isolated with laser microdissection. These two populations participate in the neuronal networks in the spinal cord where they have destinct functions in shaping (dCINs) and transferring the output to the muscles (MNs) during locomotion. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL88
22 Samples
Download data: CEL
Series
Accession:
GSE9439
ID:
200009439
18.

Intrinsic response of thoracic propriospinal neurons to axotomy

(Submitter supplied) Analysis of expression changes in prelabeled laser-microdissected thoracic propriospinal neurons at different times after low-thoracic spinal cord transection in adult rats.
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL6247
24 Samples
Download data: CEL
Series
Accession:
GSE20907
ID:
200020907
19.

Identifiation of lncRNA expression profiles and ceRNA analysis in the spinal cord of morphine tolerance rats

(Submitter supplied) The mechanism of morphine tolerance remains unclear, and lncRNA have been promising molecule in many pathophysiological processes. However, the role of lncRNA on morphine tolerance hasn’t been explored yet. So we explore this issue, and our results indicated that the expression profiles of lncRNAs have changed in morphine tolerance rats as compared with normal rats, and among those, some differentially expressed lncRNAs might be new therapeutic targets for morphine tolerance.
Organism:
Rattus norvegicus
Type:
Expression profiling by array; Non-coding RNA profiling by array
Platform:
GPL15690
10 Samples
Download data: TXT
Series
Accession:
GSE110115
ID:
200110115
20.

miRNA expression in developmental spinal cord

(Submitter supplied) This study compared the microRNA expression in mouse fetal spinal cord at day 13.5 and newborn mouse spinal cord.
Organism:
Mus musculus; Rattus norvegicus; Homo sapiens
Type:
Non-coding RNA profiling by array
Platform:
GPL18894
2 Samples
Download data: TXT
Series
Accession:
GSE59103
ID:
200059103
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