GEO DataSets

(Submitter supplied) A challenge in systems biology is to understand the gene regulatory networks that connect early cellular specification to terminal differentiation of specific cell types. In neurogenesis, neural specification has been well studied, but the link between the proneural transcriptional regulators of specification and the genes that must be activated to construct differentiated neurons is obscure. High resolution temporal profiling of gene expression reveals the events downstream of Atonal (Ato) proneural gene function in Drosophila sensory neurons. more...

Organism:

Drosophila melanogaster

Type:

Expression profiling by array

Dataset:

GDS3854

Platform:

GPL1322

31 Samples

Download data: CEL

Analysis of atonal-expressing (atoGFP+) and atoGFP- cells from transgenic wild type and ato-mutant embryos, at 3 time points corresponding to the first 3hr of neural development. Results provide insight into how proneural factors such as ato regulate specialized neuronal differentiation pathways.

Organism:

Drosophila melanogaster

Type:

Expression profiling by array, transformed count, 2 cell type, 3 development stage, 2 genotype/variation sets

Platform:

GPL1322

Series:

GSE21520

31 Samples

Download data: CEL

(Submitter supplied) The goal of this study is to identify co-expressed genes downstream of Atonal and Senseless. These gene lists are used as candidate target genes (technically: as foreground sets) in computational predictions of cis-regulatory elements using the cisTargetX method (http://med.kuleuven.be/cme-mg/lng/cisTargetX). Together, the gene expression results and cis-regulatory predictions, yield a gene regulatory network underlying the early events in retinal differentiation. more...

Organism:

Drosophila melanogaster

Type:

Expression profiling by array

Platform:

GPL1322

20 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Drosophila melanogaster

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL17275 GPL19132

85 Samples

Download data

(Submitter supplied) Ageing populations pose one of the main public health crises of our time. Reprogramming gene expression by altering the activities of sequence-specific transcription factors (TF) can ameliorate deleterious effects of age. Here we explore how a circuit of TFs coordinates pro-longevity transcriptional outcomes, which reveals a multi-tissue and multi-species role for an entire protein family: the E-twenty-six (ETS) TFs. more...

Organism:

Drosophila melanogaster

Type:

Expression profiling by high throughput sequencing

Platform:

GPL19132

12 Samples

Download data: XLSX

(Submitter supplied) Ageing populations pose one of the main public health crises of our time. Reprogramming gene expression by altering the activities of sequence-specific transcription factors (TF) can ameliorate deleterious effects of age. Here we explore how a circuit of TFs coordinates pro-longevity transcriptional outcomes, which reveals a multi-tissue and multi-species role for an entire protein family: the E-twenty-six (ETS) TFs. more...

Organism:

Drosophila melanogaster

Type:

Expression profiling by high throughput sequencing

Platform:

GPL17275

73 Samples

Download data: XLSX

(Submitter supplied) To investigate the function of RFX4 in the regulation of neurogenic differentiation, we extablished RFX4 K/O ESC cell lines by using CRISPR-Cas9 system.

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL16791

12 Samples

Download data: TXT

(Submitter supplied) Proper nervous system development is required for an organism’s survival and function. Defects in neurogenesis have been linked to neurodevelopmental disorders such as schizophrenia and autism spectrum disorders. Understanding the gene regulatory networks that orchestrate neural development, specifically cascades of proneural transcription factors, can better elucidate which genes are most essential in governing early neurogenesis. more...

Organism:

Caenorhabditis elegans

Type:

Expression profiling by high throughput sequencing

Platform:

GPL27998

8 Samples

Download data: GTF

(Submitter supplied) Pro-neural transcription factor Six3 has been implicated in neuronal differentiation. We established primary neural stem cell with Six3 overexpression, and utilized CUT&RUN to profile genomic loci bound by Six3.

Organism:

Mus musculus

Type:

Other

Platform:

GPL19057

4 Samples

Download data: BED, BW

(Submitter supplied) To study the function of Chd5 in neuronal differentiation, we cultured primary neural stem cells from WT and Chd5 deficient embryos.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL19057

12 Samples

Download data: SF

(Submitter supplied) To respond to the world around them, animals rely on the input of a network of sensory organs distributed across the body. A single individual will generally express several distinct classes of sensory organ, each bearing features that appear to enhance the detection of specific stimuli, such as strain, pressure, or light. The features that underlie this specialization relate both to the neurons housed within a sensory organ and to the various accessory cells that they are composed of. more...

Organism:

Drosophila melanogaster

Type:

Expression profiling by high throughput sequencing

Platform:

GPL25244

2 Samples

Download data: MTX, TSV

(Submitter supplied) In order to gain a greater understanding of neurotransmitter specification we profiled the transcription state of cholinergic, GABAergic and glutamatergic neurons in vivo at multiple developmental time points. We identified 86 differentially expressed transcription factors that are uniquely enriched, or uniquely depleted, in a specific neurotransmitter subtype. Some transcription factors show a similar profile across development, others only show enrichment or depletion at specific developmental stages. more...

Organism:

Drosophila melanogaster

Type:

Genome binding/occupancy profiling by high throughput sequencing

Platform:

GPL17275

31 Samples

Download data: GFF

(Submitter supplied) Neuron specification and maturation are essential for proper central nervous system development. However, the precise mechanisms that govern neuronal maturation, essential to shape and maintain neuronal circuitry, remain poorly understood. Here, we analyse early-born secondary neurons in the Drosophila larval brain revealing that the early maturation of secondary neurons goes through three consecutive phases: 1) Immediately after birth, neurons express pan-neuronal markers but do not transcribe terminal differentiation genes; 2) Transcription of terminal differentiation genes, such as neurotransmitter-related genes VGlut, ChAT or Gad1, starts shortly after neuron birth, but these transcripts are however not translated; 3) Translation of neurotransmitter-related genes only begins several hours later in mid pupa stages in a coordinated manner with animal developmental stage, albeit in an ecdysone independent-manner. more...

Organism:

Drosophila melanogaster

Type:

Expression profiling by high throughput sequencing

Platform:

GPL25244

2 Samples

Download data: TAR

(Submitter supplied) This study has successfully established a human FEV reporter system using CRISPR/Cas9 gene-editing technology. We have investigated the precise timing of FEV expression in human SNs. When compared to the previously established TPH2-reporter system, the FEV-reporter system has demonstrated the capacity to yield a greater number of highly-purified SNs, which can be utilized for in-depth exploration of the transcriptomic profiles of SNs during the differentiation process. more...

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24676

12 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24676

14 Samples

Download data: MTX, TSV

(Submitter supplied) We used single cell RNA sequencing (scRNA-seq) to analyze the diversity of serotonin neurons derived from human pluripotent stem cells (hPSCs) and to compare the transcriptomic differences between FOXA2 knockout and wide type hPSCs-derived serotonin neurons.

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24676

2 Samples

Download data: MTX, TSV

(Submitter supplied) To profile gene expression associated with BTN neurogenesis we performed RNAseq of isolated BTN lineage cells in which BTN neurogenesis was enhanced or suppressed by perturbing Neurog function.

Organism:

Ciona robusta

Type:

Expression profiling by high throughput sequencing

Platform:

GPL25724

6 Samples

Download data: XLSX