GEO DataSets

(Submitter supplied) Genome-wide association studies of transcript abundance in peripheral blood samples or derivative cell lines have demonstrated a preponderance of eSNP effects that, for the most part, involve regulatory polymorphisms in the differentially expressed gene. Several of these highlight associations that contribute to a variety of disease conditions, but the question arises as to how the associations are affected by the environment. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6947

194 Samples

Download data: TXT

(Submitter supplied) The human transitions from nomadic to agrarian to urban lifestyles are likely to impact physiology and disease susceptibility. In order to estimate the magnitude of the impact of lifestyle on genome function, we profiled gene expression in total leukocytes of Moroccan Amazigh from three distinct localities. Despite great expression heterogeneity in humans, as much as one third of the PBMC transcriptome was found to differ between the localities. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS4283

Platform:

GPL5764

46 Samples

Download data: TXT

Analysis of leukocytes from regionally distinct groups of Moroccan Amazighs leading diverse lifestyles: nomadic, rural, and urban. The Amazighs represent a genetically relatively homogeneous population. Results provide insight into effect of environment on immune function and disease susceptibility.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 gender, 3 individual sets

Platform:

GPL5764

Series:

GSE8847

46 Samples

Download data: TXT

(Submitter supplied) Genetics of gene expression (eQTLs or expression QTLs) has proved an indispensable tool for understanding biological pathways and pathomechanisms of trait associated SNPs. However, power of most genome-wide eQTL studies is still limited. We performed a large eQTL study in peripheral blood mononuclear cells of 2,112 individuals increasing the power to detect trans-effects genome-wide. Going beyond univariate SNP-transcript associations, we analyse relations of eQTLs to biological pathways, polygenetic effects of expression regulation, trans-clusters, and enrichment of co-localised functional elements. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10558

2112 Samples

Download data: TXT

(Submitter supplied) Extensive studies are currently being performed to associate disease susceptibility with one form of genetic variation, namely single nucleotide polymorphisms (SNPs). In recent years another type of common genetic variation has been characterised, namely structural variation, including copy number variations (CNVs). To determine the overall contribution of CNVs to complex phenotypes we have performed association analyses of expression levels of 14,925 transcripts with SNPs and CNVs in individuals who are part of the International HapMap project. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL2507

480 Samples

Download data: TXT

(Submitter supplied) The common genetic variants associated with complex traits typically lie in non-coding DNA and may alter gene regulation in a cell-type specific manner. Consequently, the choice of tissue or cell model in the dissection of disease associations is important. We carried out an eQTL study of primary human osteoblasts (HOb) derived from unrelated donors of Swedish origin, each represented by two independently derived primary lines to provide biological replication. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6104

187 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6947

156 Samples

Download data

(Submitter supplied) This study contrasts the expression profiles of peripheral blood leukocytes from third trimester pregnant mothers, with cord blood leukocytes from their newborn children. It is a companion to (GSE21311). After normalization for RNA integrity, major principal components of the variation were found to distinguish individuals. Transmission of gene expression profiles from mother to child was documented, along with differences between gestational diabetic, obese, and normal weight mothers and their children.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6947

56 Samples

Download data: TXT

(Submitter supplied) This is a companion study to (GSE21342). Peripheral blood leukocyte samples were obtained with consent from 100 red cross blood donors sampled cross-sectionally across the city of Brisbane, Australia. After correction for RNA integrity values, individuals fall into major profiles of expression variation suggesting environmental and cultural influences on immune gene expression.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6947

100 Samples

Download data: TXT

(Submitter supplied) This set of data was used to identify cis-regulatory SNPs by measuring allelic gene expression. From analyzing cis-regulatory SNPs from different tissues, cis-regulatory SNPs common across tissues or the cell-type specific were cataloged.

Organism:

Homo sapiens

Type:

SNP genotyping by SNP array; Genome variation profiling by SNP array

Platforms:

GPL6983 GPL6984

219 Samples

Download data: TXT

(Submitter supplied) Sequence and transcriptional variability within and between individuals are typically studied independently. The joint analysis of sequence and gene expression variation provides insight into biological mechanisms that underlie gene regulation and function. We investigated the role of sequence variation in cis on gene expression (cis sequence effects) in a group of genes frequently studied in cancer research. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL5089

30 Samples

Download data: CSV

(Submitter supplied) We measured the baseline expression levels of genes in members of the CEPH pedigrees using Affymetrix Human Genome Focus Arrays. Arrays were analyzed using MAS 5.0 software (Affymetrix). Keywords = natural variation Keywords = human Keywords: other

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL201

355 Samples

Download data: CEL

(Submitter supplied) This study explores the impact of lifestyle and environment on gene expression through whole transcriptome profiling of peripheral blood samples in Fijian population (native Melanesians and Indians) living in the rural and urban areas.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6947

41 Samples

Download data: TXT