GEO DataSets

(Submitter supplied) We identified four virulence phenotypes of Rickettsia prowazekii (the deadly agent of epidemic typhus) that are associated with the upregulation of antiapoptotic genes (virulent strain) or the Interferon I pathway (avirulent). Transcriptional and proteomic analyses of R. prowazekii linked surface protein expression and methylation with virulence. By sequencing a virulent strain and using comparative genomics, we found hotspots of mutations in homopolymeric tracts of poly(A) and poly(T) that lead to gene split and inactivation and explain the loss of virulence in the vaccine strain. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3848

Platform:

GPL4133

16 Samples

Download data: TXT

(Submitter supplied) We identified four virulence phenotypes of Rickettsia prowazekii (the deadly agent of epidemic typhus) that are associated with the upregulation of antiapoptotic genes (virulent strain) or the Interferon I pathway (avirulent). Transcriptional and proteomic analyses of R. prowazekii linked surface protein expression and methylation with virulence. By sequencing a virulent strain and using comparative genomics, we found hotspots of mutations in homopolymeric tracts of poly(A) and poly(T) that lead to gene split and inactivation and explain the loss of virulence in the vaccine strain. more...

Organism:

Rickettsia prowazekii str. Rp22; Rickettsia prowazekii; Rickettsia prowazekii str. Madrid E

Type:

Expression profiling by array

Platform:

GPL8427

3 Samples

Download data: TXT

Analysis of endothelial cells infected by R. prowazekii strains (Erus, Evir, Rp22) of varying virulence. Virulent R. prowazekii causes epidemic typhus and avirulent strains can revert to virulence. Results provide insight into the molecular basis of virulence and adaptive mutation in R. prowazekii.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 4 strain sets

Platform:

GPL4133

Series:

GSE16123

16 Samples

Download data: TXT

(Submitter supplied) Comparison of gene expression between the virulent Rickettsia rickettsii R strain and avirulent Rickettsia rickettsii Iowa. Keywords: virulent vs avirulent

Organism:

Chlamydia pneumoniae AR39; Borreliella burgdorferi B31; Coxiella burnetii RSA 493; Granulibacter bethesdensis; Coxiella burnetii; Rickettsia rickettsii; Chlamydia muridarum; Staphylococcus epidermidis RP62A; Chlamydia caviae GPIC; Staphylococcus haemolyticus JCSC1435; Staphylococcus epidermidis ATCC 12228; Staphylococcus aureus subsp. aureus MW2; Chlamydia trachomatis D/UW-3/CX

Type:

Expression profiling by array

Dataset:

GDS3427

Platform:

GPL4692

6 Samples

Download data: CEL, CHP

Comparison of the Rickettsia rickettsii virulent strain Sheila Smith and the avirulent strain Iowa. R. rickettsii is an obligate intracellular pathogen that causes Rocky Mountain spotted fever. Results provide insight in the molecular basis of virulence in R. rickettsii.

Organism:

Coxiella burnetii; Rickettsia rickettsii; Chlamydia muridarum; Chlamydophila pneumoniae AR39; Staphylococcus epidermidis RP62A; Staphylococcus epidermidis ATCC 12228; Staphylococcus aureus subsp. aureus MW2; Borrelia burgdorferi B31; Coxiella burnetii RSA 493; Chlamydophila caviae GPIC; Chlamydia trachomatis D/UW-3/CX; Staphylococcus haemolyticus JCSC1435; Granulibacter bethesdensis

Type:

Expression profiling by array, count, 2 strain sets

Platform:

GPL4692

Series:

GSE8041

6 Samples

Download data: CEL, CHP