GEO DataSets

(Submitter supplied) Staphylococcus aureus is one of the most important pathogens in humans and animals, multiply resistant strains are increasingly widespread, new agents are needed for the treatment of S. aureus. Rhein, a natural plant product, has potential antimicrobial activity against Staphylococcus aureus. We employed Affymetrix Staphylococcus aureus GeneChipsTM arrays to investigate the global transcriptional profiling of Staphylococcus aureus ATCC25923 treated with rhein. more...

Organism:

Staphylococcus aureus

Type:

Expression profiling by array

Dataset:

GDS2812

Platform:

GPL1339

6 Samples

Download data: CEL

Analysis of Staphylococcus aureus ATCC25923 cultures treated with subinhibitory concentrations of rhein for 45 minutes. Rhein is an antimicrobial agent from rhubarb. Results provide insight into the efficacy of rhein against Staphylococcus aureus.

Organism:

Staphylococcus aureus

Type:

Expression profiling by array, count, 2 agent sets

Platform:

GPL1339

Series:

GSE8135

6 Samples

Download data: CEL

(Submitter supplied) Staphylococcus aureus (S. aureus) is an important human and animal pathogen, multiply resistant strains are increasingly widespread, new agents are needed for the treatment of S. aureus. Berberine chloride (BBR), a natural plant product, has potent antimicrobial activity against S. aureus. We employed Affymetrix Staphylococcus aureus GeneChipsTM arrays to investigate the global transcriptional profiling of Staphylococcus aureus ATCC25923 treated with berberine chloride. more...

Organism:

Staphylococcus aureus

Type:

Expression profiling by array

Dataset:

GDS2814

Platform:

GPL1339

6 Samples

Download data: CEL

Analysis of Staphylococcus aureus ATCC25923 cultures treated with berberine chloride. Results provide insight into the antimicrobial activity of berberine chloride against Staphylococcus aureus.

Organism:

Staphylococcus aureus

Type:

Expression profiling by array, count, 2 agent sets

Platform:

GPL1339

Series:

GSE7944

6 Samples

Download data: CEL

(Submitter supplied) In the present study, we employed Affymetrix Staphylococcus aureus GeneChip arrays to investigate the dynamics of global gene expression profiles during the cellular response of Staphylococcus aureus to triclosan, which involved initial growth inhibition and metabolism. Keywords: Transcriptome study; antimicrobial response; time course

Organism:

Staphylococcus aureus

Type:

Expression profiling by array

Dataset:

GDS2983

Platform:

GPL1339

15 Samples

Download data: CEL

Analysis of Staphylococcus aureus cultures treated for 10 or 60 minutes with 0.05 uM triclosan. At this concentration, the antimicrobial agent caused growth inhibition for about 10 min. Results provide insight into the initial molecular response of Staphylococcus aureus to triclosan.

Organism:

Staphylococcus aureus

Type:

Expression profiling by array, count, 2 agent, 3 time sets

Platform:

GPL1339

Series:

GSE8861

15 Samples

Download data: CEL

(Submitter supplied) Staphylococcus aureus (S. aureus) is an important human and animal pathogen, multiply resistant strains are increasingly widespread, new agents are needed for the treatment of S. aureus. Cryptotanshinone, a natural plant product, has potent antimicrobial activity against S. aureus. We employed Affymetrix Staphylococcus aureus GeneChipsTM arrays to investigate the global transcriptional profiling of Staphylococcus aureus ATCC25923 treated with cryptotanshinone. more...

Organism:

Staphylococcus aureus

Type:

Expression profiling by array

Platform:

GPL1339

6 Samples

Download data: CEL

(Submitter supplied) Pure cultures of ammonia oxidizing bacterium, Nitrosomonas europaea, are exposed to cyanide in pseudo-steady state batch reactor in presence of ammonia. Nitrosomonas europaea are generally regarded as the most sensitive organism to various inhibitors commonly encountered in the wastewater treatment plants (WWTP). To find stress genes of Nitrosomonas europaea to cyanide known as inhibitor of respiratory process, whole-genome transcript response to cyanide was determined in this research using microarray and qRT-PCR. more...

Organism:

Nitrosomonas europaea

Type:

Expression profiling by array

Platform:

GPL4617

6 Samples

Download data: CEL

(Submitter supplied) To understand the host transcriptional response to S. enterica serovar Choleraesuis (S. Choleraesuis), the first generation Affymetrix porcine GeneChip® was used to identify differentially expressed genes in the mesenteric lymph nodes responding to infection at acute (8 hours (h), 24h, 48h post-inoculation (pi)) and chronic stages (21 days (d) pi) The objectives of this study were to identify and examine the stereotypical gene expression response within the host mesenteric lymph nodes to S. more...

Organism:

Sus scrofa

Type:

Expression profiling by array

Platform:

GPL3533

15 Samples

Download data: CEL, EXP

(Submitter supplied) Approximatively 75% of the genome of S. aureus (“core” genome) are highly conserved between strains, whereas the remaining 25% (“accessory” genome) are composed of variable regions that are mostly composed of mobile genetic elements (MGE), containing virulence and resistance genes. We have developed a composite DNA-microarray (StaphVar Array) which selectively targets 403 genes located on the accessory or core variable genome. more...

Organism:

Staphylococcus aureus

Type:

Genome variation profiling by array

Platform:

GPL7684

26 Samples

Download data: GPR

(Submitter supplied) Gene expression in human umbilical vein endothelial cells (HUVEC) was investigated by microarray analysis after 4 h infection with S. aureus isolated from healthy nasal carriers (n=5) and from blood (n=5) of septic patients. All bacterial isolates were spa-typed and characterized with a DNA microarray to determine the presence of virulence genes. Keywords: infection studies, pathogen, S. aureus

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS4030

Platform:

GPL570

12 Samples

Download data: CEL

Analysis of human umbilical vein endothelial cells (HUVECs) infected with S. aureus from nares of healthy carriers or from blood of septic patients (i.e. representing a disseminated disease). Results provide insight into interactions between HUVECs and virulent/non-virulent S. aureus isolates.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 4 infection sets

Platform:

GPL570

Series:

GSE13736

12 Samples

Download data: CEL

(Submitter supplied) d-serine is naturally present throughout the human body. It is also used as add-on therapy for treatment-refractory schizophrenia. d-Serine interacts with the strychnine-insensitive glycine binding site of NMDA receptor, and this interaction could lead to potentially toxic activity (i.e., excitotoxicity) in brain tissue. The transcriptomic changes that occur in the brain after d-serine exposure have not been fully explored. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS3643

Platform:

GPL1355

24 Samples

Download data: CEL

Analysis of forebrains of animals treated with up to 500 mg/kg D-serine for 96 hours. D-serine is involved in many physiological processes through its interaction with the glycine binding site of the NMDA receptor. Results provide insight into the impact of D-serine exposure on neuronal functions.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 agent, 6 dose sets

Platform:

GPL1355

Series:

GSE10748

24 Samples

Download data: CEL

(Submitter supplied) In the present study, we employed Affymetrix Staphylococcus aureus GeneChip arrays to investigate the dynamics of global gene expression profiles during the cellular response of Staphylococcus aureus to hypochlorite, which involved initial growth inhibition and subsequent partial recovery. Keywords: Time course

Organism:

Staphylococcus aureus

Type:

Expression profiling by array

Platform:

GPL1339

12 Samples

Download data

(Submitter supplied) In the present study, we employed Affymetrix Staphylococcus aureus GeneChip arrays to investigate the dynamics of global gene expression profiles during the cellular response of Staphylococcus aureus to hydrogen peroxide-induced oxidative stress, which involved initial growth inhibition and subsequent recovery. Keywords: Time course

Organism:

Staphylococcus aureus

Type:

Expression profiling by array

Dataset:

GDS1666

Platform:

GPL1339

12 Samples

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Analysis of Staphylococcus aureus cells exposed for 10 or 20 minutes to hydrogen peroxide to induce oxidative stress. Macrophages and other lymphocytes use reactive oxygen species such as H2O2 to destroy the bacteria. Results provide insight into mechanisms involved in S. aureus-host interactions.

Organism:

Staphylococcus aureus

Type:

Expression profiling by array, count, 2 agent, 2 time sets

Platform:

GPL1339

Series:

GSE3415

12 Samples

Download data

(Submitter supplied) In the present study, we employed Affymetrix Staphylococcus aureus GeneChip arrays to investigate the dynamics of global gene expression profiles during the cellular response of Staphylococcus aureus to Ortho-Phenylphenol, which involved initial growth inhibition and metabolism. Keywords: Time course

Organism:

Staphylococcus aureus

Type:

Expression profiling by array

Platform:

GPL1339

15 Samples

Download data: CEL

(Submitter supplied) In the present study, we employed Affymetrix Staphylococcus aureus GeneChip arrays to investigate the dynamics of global gene expression profiles during the cellular response of Staphylococcus aureus to peracetic acid, which involved initial growth inhibition and subsequent partial recovery. Keywords: Time course

Organism:

Staphylococcus aureus

Type:

Expression profiling by array

Dataset:

GDS2105

Platform:

GPL1339

12 Samples

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Analysis of Staphylococcus aureus cultures at 10 and at 20 minutes following treatment with 1 mM peracetic acid, an antimicrobial disinfectant. Results provide insight into the toxicogenomic response of S. aureus to a sublethal concentration of peracetic acid during the two growth states.

Organism:

Staphylococcus aureus

Type:

Expression profiling by array, count, 2 agent, 2 time sets

Platform:

GPL1339

Series:

GSE4184

12 Samples

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