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Links from GEO DataSets

Items: 7

1.

p300-mediated gene expression during muscle cell survival

(Submitter supplied) Type of experiment: The primary focus of these studies is to define the transcriptional network regulated by ectopic expression of the transcriptional co-activator protein, p300, in order to define its mechanism(s) of action in promoting muscle cell survival. Experimental factors: Our laboratory has generated a murine C2-derived myoblast cell line stably expressing an IGF-II cDNA in antisense orientation (C2AS12 cells). more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS1821
Platform:
GPL81
6 Samples
Download data: PDF
Series
Accession:
GSE4224
ID:
200004224
2.
Full record GDS1821

Muscle cell survival mediated by transcriptional coactivator p300

Analysis of insulin growth factor II deficient C2AS12 myoblasts expressing wild type or protein interaction domain mutant p300 at 0 and 24 hours after a switch to low serum media. Wild type but not the mutant p300 prevents the progressive cell death induced by serum withdrawal.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 agent, 2 genotype/variation, 2 time sets
Platform:
GPL81
Series:
GSE4224
6 Samples
Download data
DataSet
Accession:
GDS1821
ID:
1821
3.

Alteration of gene expression in two cell lines upon inhibition of PCAF by embelin

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens; Mus musculus
Type:
Expression profiling by array
Platforms:
GPL6887 GPL6480
16 Samples
Download data: TXT
Series
Accession:
GSE39829
ID:
200039829
4.

Alteration of gene expression in HEK 293T cells upon inhibition of PCAF by embelin

(Submitter supplied) KAT2B (PCAF) belongs to GNAT family of lysine acetyltransferases (KAT), which specifically acetylates histone H3K9 residue and several nonhistone proteins. PCAF is also a transcription coactivator. Due to the lack of PCAF, KAT specific small molecule inhibitor, the exclusive role of the acetyltransferase activity of PCAF is not well understood. Here we report that a hydroxy benzoquinone class of natural compound, embelin, specifically inhibits H3Lys9 acetylation in mice and recombinant PCAF mediated acetylation with near complete specificity in vitro. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6480
4 Samples
Download data: TXT
Series
Accession:
GSE39828
ID:
200039828
5.

Alteration of gene expression in differentiating C2C12 cells upon inhibition of PCAF by embelin

(Submitter supplied) KAT2B (PCAF) belongs to GNAT family of lysine acetyltransferases (KAT), which specifically acetylates histone H3K9 residue and several nonhistone proteins. PCAF is also a transcription coactivator. Due to the lack of PCAF, KAT specific small molecule inhibitor, the exclusive role of the acetyltransferase activity of PCAF is not well understood. Here we report that a hydroxy benzoquinone class of natural compound, embelin, specifically inhibits H3Lys9 acetylation in mice and recombinant PCAF mediated acetylation with near complete specificity in vitro. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6887
12 Samples
Download data: TXT
Series
Accession:
GSE39827
ID:
200039827
6.

ChIP-seq profiling of transcriptional co-activator p300 during early myogenic differentiation

(Submitter supplied) Molecular regulation of stem cell differentiation is exerted through both genetic and epigenetic determinants over distal regulatory or enhancer regions. Understanding the mechanistic action of active or poised enhancers is thus imperative for control of stem cell differentiation. Based on a genome-wide co-occurrence of different epigenetic marks in committed proliferating myoblasts, we have previously generated a 14-state chromatin state model to profile residue-specific histone acetylation in early myoblast differentiation. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL13112
3 Samples
Download data: BIGWIG, BW
Series
Accession:
GSE109636
ID:
200109636
7.

Analysis of the common and respective roles of CBP and p300 co-activators in human primary myoblast differentiation.

(Submitter supplied) We used Affymetrix microarrays to detail the global programme of gene expression regulated by CBP and/or p300 during human primary myoblast differentiation.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL16686
21 Samples
Download data: CEL
Series
Accession:
GSE94006
ID:
200094006
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Supplemental Content

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