GEO DataSets

(Submitter supplied) PI-3K inhibitor (LY294002) was added to quiescent fibroblasts 30 minutes prior growth factor/serum treatments. The role of PI-3K pathway was thus monitored by comparing with untreated samples. Keywords: time course, growth factor response, cell line comparison

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL3279

20 Samples

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(Submitter supplied) Quiescent human fibroblasts (2091 and Wi-38) were stimulated with different growth factors and serum. Cells were collected at 6 different time points followed by global transcriptional profiling. Keywords: time course, growth factor response, cell line comparison

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL3279

120 Samples

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(Submitter supplied) The temporal program of gene expression during a model physiological response of human cells, the response of fibroblasts to serum, was explored with a complementary DNA microarray representing about 8600 different human genes. Genes could be clustered in groups on the basis of their temporal patterns of expression in this program. Many features of the transcriptional program appeared to be related to the physiology of wound repair suggesting that fibroblasts play a larger and richer role in this complex multicellular response than had previously been appreciated. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Datasets:

GDS85 GDS86

Platforms:

GPL168 GPL169

18 Samples

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(Submitter supplied) The transcriptional program in the response of human fibroblasts to serum control group. This study is described more fully in Iyer VR, et al. 1999. Science 283:83-7 Keywords: other

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL169

2 Samples

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(Submitter supplied) The transcriptional program in the response of human fibroblasts to serum. Serum was added to fibroblasts in the presence of cycloheximide. This study is described more fully in Iyer VR, et al. 1999. Science 283:83-7 Keywords: time-course

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS145

Platform:

GPL169

4 Samples

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(Submitter supplied) The transcriptional program in the response of human fibroblasts to serum. Serum was added to fibroblasts, and samples were taken. This study is described more fully in Iyer VR, et al. 1999. Science 283:83-7 Keywords: time-course

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL168 GPL169

12 Samples

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Analysis of the transcriptional program in the response of human fibroblasts to serum. Serum added to fibroblasts in the presence of cycloheximide and samples taken at 0, 0.5, 2 and 4 hours.

Organism:

Homo sapiens

Type:

Expression profiling by array, log ratio, 4 time sets

Platform:

GPL169

Series:

GSE56

4 Samples

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Analysis of a temporal transcriptional program in the response of primary fibroblast cultures to serum. Samples taken at 15 minutes and 2 hours.

Organism:

Homo sapiens

Type:

Expression profiling by array, log ratio, 2 time sets

Platform:

GPL168

Series:

GSE58

2 Samples

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Temporal transcriptional program of primary fibroblasts in response to serum. Samples taken at various time points up to 24 hours.

Organism:

Homo sapiens

Type:

Expression profiling by array, log ratio, 10 time sets

Platform:

GPL169

Series:

GSE58

10 Samples

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(Submitter supplied) To analyze the effect of Exportin-5 expression on the MEF cells in cell cycle re-entry phase, we have employed whole genome microarray expression profiling on the MEF cells in cell cycle re-entry phase with and without down regulation of Exportin-5 gene.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL7202

4 Samples

Download data: TXT

(Submitter supplied) Data set to accompany : Anatomic demarcation by positional variation in fibroblast gene expression programs. PLoS Genet. 2006 Jul;2(7):e119. PMID: 16895450 Fibroblasts are ubiquitous mesenchymal cells with many vital functions during development, tissue repair, and disease. Fibroblasts from different anatomic sites have distinct and characteristic gene expression patterns, but the principles that govern their molecular specialization are poorly understood. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL4214 GPL4213

48 Samples

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(Submitter supplied) Foreskin fibroblasts CRL 2091 (ATCC) were serum starved for 48 hours, and harvested at the indicated time points after switching to media with 10% FBS essentially as described (Iyer et al., 1999). RNA from all of the sampled time points were pooled as reference RNA to compare with RNA from individual time points as described (Iyer et al., 1999). Groups of assays that are related as part of a time series. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS1568

Platform:

GPL2670

18 Samples

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(Submitter supplied) A fundamental feature of the architecture and functional design of vertebrate animals is a stroma, composed of extracellular matrix and mesenchymal cells, which provides a structural scaffold and conduit for blood and lymphatic vessels, nerves, and leukocytes. Reciprocal interactions between mesenchymal and epithelial cells are known to play a critical role in orchestrating the development and morphogenesis of tissues and organs, but the roles played by specific stromal cells in controlling the design and function of tissues remain poorly understood. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL3042 GPL1282 GPL3043

50 Samples

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Analysis of fibroblasts at various time points up to 36 hours after serum stimulation. The fibroblast serum response represents a wound healing program; cancer progression is likened to wound healing gone awry. Results provide insight into the significance of the wound healing process in cancer.

Organism:

Homo sapiens

Type:

Expression profiling by array, log2 ratio, 2 agent, 16 time sets

Platform:

GPL2670

Series:

GSE3945

18 Samples

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