GSM7295761[Accession] - GEO DataSets

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Items: 4

Select item 2002316811.

p53 governs an alveolar type 1 differentiation program in lung cancer suppression

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platforms:: GPL21103 GPL19057 GPL24247
45 Samples

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Series

Accession:: GSE231681

ID:: 200231681

PubMed Full text in PMC Similar studies

Select item 2002316772.

p53 governs an alveolar type 1 differentiation program in lung cancer suppression [in_vivo_ATAC_seq2]

(Submitter supplied) Lung cancer is the leading cause of cancer deaths worldwide. TP53 tumor suppressor gene mutations occur in 50% of lung adenocarcinomas (LUADs) and are linked to poor prognosis, but how p53 suppresses LUAD development remains enigmatic. We show here that p53 suppresses LUAD by governing cell state, by promoting alveolar type 1 (AT1) differentiation. Using mice expressing oncogenic Kras and null, wild-type, or hypermorphic p53 alleles in alveolar type 2 (AT2) cells, we observed graded effects of p53 on LUAD initiation and progression. more...