GEO DataSets

(Submitter supplied) Renal infiltration with mononuclear cells is associated with poor prognosis in SLE. A renal macrophage/dendritic cell signature is associated with onset of nephritis in NZB/W mice and immune modulating therapies can reverse this signature and the associated renal damage despite ongoing immune complex deposition. Our findings suggest that mononuclear phagocytes with an aberrant activation profile contribute to tissue damage in lupus nephritis by mediating both local inflammation and excessive tissue remodeling. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS4194

Platform:

GPL7546

17 Samples

Download data: CEL

Analysis of F4/80hi renal macrophages isolated at an early stage of lupus, during lupus nephritis, and after induction of remission. The infiltrating F4/80hi cells are associated with renal damage. Results provide insight into mechanisms by which F4/80hi macrophages contribute to lupus nephritis.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 3 tissue sets

Platform:

GPL7546

Series:

GSE27045

17 Samples

Download data: CEL

(Submitter supplied) CDF file was created by Microarray Lab at the Molecular and Behavioral Neuroscience Institute at the University of Michigan. Oligonucleotide probes on GeneChips were reorganized based on the latest genome and transcriptome information. In this particular case the Entrez Gene database (build: Jun 28, 2007) was used as source. For the CDF file based on Entrez Gene: A probe must hit only one genomic location; Probes that can be mapped to the same target sequence in the correct direction are grouped together in the same probe set; Each probe set must contain at least three oligonucleotide probes and probes in a set are ordered according to their location in the corresponding exon. more...

Organism:

Mus musculus

2 DataSets

16 Series

1 Related Platform

295 Samples

Download data: TAR