GSM618235[Accession] - GEO DataSets

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Items: 3

Select item 2000209451.

Effects of DAC treatment

(Submitter supplied) Reversal of gene promoter DNA hypermethylation and associated abnormal gene silencing is an attractive approach to cancer therapy. The DNA methylation inhibitor, decitabine (5-aza-2'-deoxycitidine), is proving efficacious for hematological neoplasms especially at lower, less toxic, doses. Experimentally, high doses induce rapid DNA damage and cytotoxicity, but these may not explain the prolonged time to response seen in patients. more...

Organism:: Homo sapiens

Type:: Expression profiling by array; Methylation profiling by array

4 related Platforms
55 Samples

Download data: TXT

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Accession:: GSE20945

ID:: 200020945

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 1000084902.

Illumina HumanMethylation27 BeadChip (HumanMethylation27_270596_v.1.2)

(Submitter supplied) HumanMethylation27 DNA Analysis BeadChip allows researchers to interrogate 27,578 highly informative CpG sites per sample at single-nucleotide resolution. This 12-sample BeadChip features content derived from the well-annotated NCBI CCDS database (Genome Build 36) and is supplemented with more than 1,000 cancer-related genes described in published literature. Probe content has been enriched to deeply cover more than 150 well-established cancer genes known to show differential methylation patterns. more...