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Items: 4

1.

A phase separation mechanism underlies development of cancer and aberrant organization of three-dimensional chromatin structure

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus; Homo sapiens
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other
4 related Platforms
56 Samples
Download data: HIC
Series
Accession:
GSE144643
ID:
200144643
2.

Phase separation drives aberrant chromatin looping and cancer development [ChIP-Seq]

(Submitter supplied) Development of cancer is intimately associated with genetic abnormalities that target proteins with intrinsically disordered regions (IDRs). In human hematological malignancies, recurrent chromosomal translocation of nucleoporin (NUP98 or NUP214) generates an aberrant chimera that invariably retains nucleoporin?s IDR, tandemly dispersed phenylalanine-and-glycine (FG) repeats. However, it remains elusive how unstructured IDRs contribute to oncogenesis. more...
Organism:
Homo sapiens; Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL21626 GPL21697 GPL16791
30 Samples
Download data: BW
Series
Accession:
GSE144076
ID:
200144076
3.

Illumina HiSeq 2500 (Homo sapiens)

Platform
Accession:
GPL16791
ID:
100016791
4.

HEK293 WT NUP98-HOXA9 (HA) H3K27ac Input

Organism:
Homo sapiens
Source name:
HEK 293 cells
Platform:
GPL16791
Series:
GSE144076 GSE144643
Download data
Sample
Accession:
GSM5269340
ID:
305269340
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