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Items: 3

1.

Combinatorial optimization of mRNA structure, stability, and translation for RNA-based therapeutics

(Submitter supplied) Therapeutic mRNAs and vaccines are being developed for a broad range of human diseases, including COVID-19. However, their optimization is hindered by mRNA instability and inefficient protein expression. Here, we describe design principles that overcome these barriers. We develop a new RNA sequencing-based platform called PERSIST-seq to systematically delineate in-cell mRNA stability, ribosome load, as well as in-solution stability of a library of diverse mRNAs. more...
Organism:
synthetic construct; Homo sapiens
Type:
Other
Platforms:
GPL27609 GPL17769 GPL21697
70 Samples
Download data: RDAT, XLSX
Series
Accession:
GSE173083
ID:
200173083

PubMed Full text in PMC Similar studies SRA Run Selector

2.

NextSeq 550 (Homo sapiens)

Organism:
Homo sapiens
1499 Series
44577 Samples
Download data
Platform
Accession:
GPL21697
ID:
100021697

3.

RNA in-solution timepoint 3

Organism:
Homo sapiens
Source name:
Cell culture
Platform:
GPL21697
Series:
GSE173083
Download data
Sample
Accession:
GSM5259552
ID:
305259552

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db=gds|term=GSM5259552[Accession]|query=1|qty=3|blobid=MCID_6748cbaa462e1a751e108215|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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