GSM4669304[Accession] - GEO DataSets

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Items: 4

Select item 2001543471.

Identification of pharmacologic inhibitors and activators of IL-4-induced macrophage polarization in PBMC and THP-1 cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL21697
81 Samples

Download data: TXT

Series

Accession:: GSE154347

ID:: 200154347

PubMed Full text in PMC Similar studies

Select item 2001543462.

Identification of pharmacologic inhibitors and activators of IL-4-induced macrophage polarization [THP-1 RNA-seq]

(Submitter supplied) Macrophages polarize towards different subpopulations with distinct and partly antagonistic functions in various diseases. IFNγ/LPS-polarized M1-type macrophages can have antiangiogenic activity, whereas IL-4-induced M2-type macrophages can be proangiogenic and profibrotic. Therapeutic strategies to inhibit M2-type polarization while promoting M1-type polarization could serve to inhibit pathological angiogenesis and fibrosis. more...