GSM3985209[Accession] - GEO DataSets

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Items: 4

Select item 2001350931.

Transcription-driven cohesin accumulation is associated with secretory phenotype of senescence

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing; Other

Platforms:: GPL16791 GPL24676 GPL20301
74 Samples

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Series

Accession:: GSE135093

ID:: 200135093

PubMed Full text in PMC Similar studies

Select item 2001350882.

Transcription-driven cohesin accumulation is associated with secretory phenotype of senescence [ChIP-Seq]

(Submitter supplied) Senescence is a stable form of cell cycle arrest that is triggered in response to various pathophysiological stimuli. The three-dimensional structure of senescent cells has been previously characterised, mostly in terms of macro-domains or changes between large heterochromatic regions. In the present body of work, using a combination of HiC and targetted Capture Hi-C, we aimed to investigate the association between gene expression and local chromatin structure in senescence, particularly focusing on enhancer-promoter (EP) interactions. more...