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Items: 4

1.

Monocytes of patients with familial hypercholesterolemia show alterations in cholesterol metabolism

(Submitter supplied) Background: Elevated plasma cholesterol promotes the formation of atherosclerotic lesions in which monocyte-derived lipid-laden macrophages are frequently found. To analyze, if circulating monocytes already show increased lipid content and differences in lipoprotein metabolism, we compared monocytes from patients with Familial Hypercholesterolemia (FH) with those from healthy individuals. Methods: Cholesterol and oxidized cholesterol metabolite serum levels of FH and of healthy, gender/age matched control subjects were measured by combined gas chromatography ? mass spectroscopy. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS3668
Platform:
GPL570
23 Samples
Download data: CEL
Series
Accession:
GSE6054
ID:
200006054
2.
Full record GDS3668

Familial hypercholesterolemia and atherosclerosis: monocytes

Analysis of monocytes (MO) from familial hypercholesterolemia (FH) patients. FH patients have a defective or missing LDLR resulting in atherosclerosis. Atherosclerotic lesions often contain MO-derived, lipid-laden macrophages. Results provide insight into the role of MO in onset of atherosclerosis.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 3 disease state sets
Platform:
GPL570
Series:
GSE6054
23 Samples
Download data: CEL
3.

[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 06, 2012: annotation table updated with netaffx build 32 June 23, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site Complete coverage of the Human Genome U133 Set plus 6,500 additional genes for analysis of over 47,000 transcripts All probe sets represented on the GeneChip Human Genome U133 Set are identically replicated on the GeneChip Human Genome U133 Plus 2.0 Array. more...
Organism:
Homo sapiens
602 DataSets
5672 Series
61 Related Platforms
175702 Samples
Download data
Platform
Accession:
GPL570
ID:
100000570
4.

control participant P307

Organism:
Homo sapiens
Source name:
human CD14 positive monopcytes
Platform:
GPL570
Series:
GSE6054
Dataset:
GDS3668
Download data: CEL
Sample
Accession:
GSM140245
ID:
300140245
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