GSM1342805[Accession] - GEO DataSets

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Items: 4

Select item 2000557591.

Promoter methylome and integrative transcriptome profiling identify key epigenetics-regulated genes in human HCCs

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Methylation profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platforms:: GPL11154 GPL9052
32 Samples

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Series

Accession:: GSE55759

ID:: 200055759

PubMed Full text in PMC Similar studies

Select item 2000557522.

Promoter methylome and integrative transcriptome profiling identify key epigenetics-regulated genes in human HCCs [methylation]

(Submitter supplied) Hepatocellular carcinoma (HCC) is one of the most common and lethal cancers worldwide and has a poor prognosis. Promoters represent an essential regulatory element of gene transcription in the human genome. In order to understand the promoter methylation in relation with gene transcription in HCCs, we applied a liquid hybridization capture-based bisulfite sequencing (LHC-BS) approach to examine the promoter methylome of HCCs, for which we customized 150,407 capture probes and enabled coverage of 91.8% of the RefSeq gene promoters within the human genome. more...