GSM1085663[Accession] - GEO DataSets

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Items: 3

Select item 2000444541.

Presenilins mediate endosomal recycling via ARF6 to maintain proper lysosomal clearance

(Submitter supplied) Autophagic and endosomal dysfunctions are prominently observed at preclinical stages of Alzheimer's disease (AD) as well as in presenilin (PSEN) 1-deficient mice and neurons. In the latter, the defects relate to the γ-secretase-independent role of PSEN in lysosomal fusion and organelle turnover. While we demonstrated previously that the impaired capacity of lysosomal fusion is associated with a significant reduction in lysosomal calcium storage/release, the underlying mechanism remained unexplored. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL11202
12 Samples

Download data: TXT

Series

Accession:: GSE44454

ID:: 200044454

Analyze with GEO2R

Select item 1000112022.

Agilent-026655 Whole Mouse Genome Microarray 4x44K v2 (Probe Name version)

(Submitter supplied) *** The ID column includes the Agilent Probe Names. A different version of this platform with the Agilent Feature Extraction feature numbers in the ID column is assigned accession number GPL10333. Protocol: see manufacturer's web site at http://www.agilent.com/