GSM1011290[Accession] - GEO DataSets

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Items: 3

Select item 2000412591.

Single-Stranded Annealing Induced by Re-Initiation of Replication Origins Provides a Novel and Efficient Mechanism for Generating Copy Number Expansion via Non-Allelic Homologous Recombination.

(Submitter supplied) Copy number expansions such as amplifications and duplications contribute to human phenotypic variation, promote molecular diversification during evolution, and drive the initiation and/or progression of various cancers. The mechanisms underlying these copy number changes are still incompletely understood, however. We recently demonstrated that transient, limited re-replication from a single origin in Saccharomyces cerevisiae efficiently induces segmental amplification of the re-replicated region. more...

Organism:: Saccharomyces cerevisiae

Type:: Genome variation profiling by genome tiling array

Platform:: GPL3412
333 Samples

Download data: GPR

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Accession:: GSE41259

ID:: 200041259

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 1000034122.

Li UCSF yeast 14062 v1.0

(Submitter supplied) PCR products representing ORF and intergenic yeast genomic sequences were amplified. Products were spotted on poly-L-lysine coated glass slides using a linear servo arrayer from the DeRisi Lab at UCSF. Blast analysis of oligos sequences was used to determine the position of the final PCR product. Those oligo pairs which Blast analysis indicated could not generate a product or generated more than one product given the flag –1. more...