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Items: 13

1.

Modeling the ESR1 tyrosine 537 mutation with CRISPR-Cas9 for mechanistic studies and evaluation of therapeutic approaches for metastatic breast cancer [RNA-Seq]

(Submitter supplied) Estrogen receptor-α (ERα) is an important driver of breast cancer and is the target for hormonal therapies, anti-estrogens and drugs that limit estrogen biosynthesis (aromatase inhibitors). Mutations in the ESR1 gene identified in metastatic breast cancer provide a potential mechanism for acquired resistance to hormone therapies. We have used CRISPR-Cas9 mediated genome editing in the MCF-7 breast cancer cell line, generating MCF-7-Y537S. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL16791
11 Samples
Download data: XLSX
Series
Accession:
GSE78285
ID:
200078285

PubMed Full text in PMC Similar studies Analyze with GEO2RSRA Run Selector

2.

Illumina HiSeq 2500 (Homo sapiens)

Organism:
Homo sapiens
12302 Series
351173 Samples
Download data
Platform
Accession:
GPL16791
ID:
100016791

3.

Y537S E2_68

Organism:
Homo sapiens
Source name:
MCF7-Luc cells
Platform:
GPL16791
Series:
GSE78285 GSE78286
Download data
Sample
Accession:
GSM2071236
ID:
302071236

SRA Run Selector

4.

Y537S E2_67

Organism:
Homo sapiens
Source name:
MCF7-Luc cells
Platform:
GPL16791
Series:
GSE78285 GSE78286
Download data
Sample
Accession:
GSM2071235
ID:
302071235

SRA Run Selector

5.

Y537S Veh_66

Organism:
Homo sapiens
Source name:
MCF7-Luc cells
Platform:
GPL16791
Series:
GSE78285 GSE78286
Download data
Sample
Accession:
GSM2071234
ID:
302071234

SRA Run Selector

6.

Y537S Veh_63

Organism:
Homo sapiens
Source name:
MCF7-Luc cells
Platform:
GPL16791
Series:
GSE78285 GSE78286
Download data
Sample
Accession:
GSM2071233
ID:
302071233

SRA Run Selector

7.

Y537S Veh_62

Organism:
Homo sapiens
Source name:
MCF7-Luc cells
Platform:
GPL16791
Series:
GSE78285 GSE78286
Download data
Sample
Accession:
GSM2071232
ID:
302071232

SRA Run Selector

8.

MCF7 E2_10

Organism:
Homo sapiens
Source name:
MCF7-Luc cells
Platform:
GPL16791
Series:
GSE78285 GSE78286
Download data
Sample
Accession:
GSM2071231
ID:
302071231

SRA Run Selector

9.

MCF7 E2_9

Organism:
Homo sapiens
Source name:
MCF7-Luc cells
Platform:
GPL16791
Series:
GSE78285 GSE78286
Download data
Sample
Accession:
GSM2071230
ID:
302071230

SRA Run Selector

10.

MCF7 E2_7

Organism:
Homo sapiens
Source name:
MCF7-Luc cells
Platform:
GPL16791
Series:
GSE78285 GSE78286
Download data
Sample
Accession:
GSM2071229
ID:
302071229

SRA Run Selector

11.

MCF7 Veh_6

Organism:
Homo sapiens
Source name:
MCF7-Luc cells
Platform:
GPL16791
Series:
GSE78285 GSE78286
Download data
Sample
Accession:
GSM2071228
ID:
302071228

SRA Run Selector

12.

MCF7 Veh_4

Organism:
Homo sapiens
Source name:
MCF7-Luc cells
Platform:
GPL16791
Series:
GSE78285 GSE78286
Download data
Sample
Accession:
GSM2071227
ID:
302071227

SRA Run Selector

13.

MCF7 Veh_3

Organism:
Homo sapiens
Source name:
MCF7-Luc cells
Platform:
GPL16791
Series:
GSE78285 GSE78286
Download data
Sample
Accession:
GSM2071226
ID:
302071226

SRA Run Selector

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