GSE64301[Accession] - GEO DataSets - NCBI

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Select item 2000643011.

SUMOylation regulates the protein network and chromatin accessibility at glucocorticoid receptor-binding sites [sequencing]

(Submitter supplied) Glucocorticoid receptor (GR) is an essential transcription factor (TF), controlling metabolism, development and immune responses. SUMOylation regulates chromatin occupancy and target gene expression of GR in a locus-selective manner, but the mechanism of regulation has remained elusive. Here, we identify the protein network around chromatin-bound GR by using selective isolation of chromatin-associated proteins and show that the network is affected by receptor SUMOylation, with several nuclear receptor coregulators and chromatin modifiers preferring interaction with SUMOylation-deficient GR and proteins implicated in transcriptional repression preferring interaction with SUMOylation-competent GR. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platforms:: GPL11154 GPL18573
81 Samples

Download data: BEDGRAPH

Series

Accession:: GSE64301

ID:: 200064301

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 1000185732.

Illumina NextSeq 500 (Homo sapiens)

Organism:: Homo sapiens

12602 Series
343758 Samples

Platform

Accession:: GPL18573

ID:: 100018573

Select item 1000111543.

Illumina HiSeq 2000 (Homo sapiens)

Organism:: Homo sapiens

10557 Series
183715 Samples

Platform

Accession:: GPL11154

ID:: 100011154

Select item 3049556044.

HEK293flpGR3KR_RNAseq_ML792-Dex_rep2

Organism:: Homo sapiens

Source name:: Isogenic HEK293 cells, SUMOylation-defective GR (GR3KR), ML-792 + dex, RNA

Platform:: GPL18573
Series:: GSE64301 GSE64373

Download data: BEDGRAPH

Sample

Accession:: GSM4955604

ID:: 304955604

SRA Run Selector

Select item 3049556035.

HEK293flpGR3KR_RNAseq_ML792-Dex_rep1

Organism:: Homo sapiens

Source name:: Isogenic HEK293 cells, SUMOylation-defective GR (GR3KR), ML-792 + dex, RNA

Platform:: GPL18573
Series:: GSE64301 GSE64373

Download data: BEDGRAPH

Sample

Accession:: GSM4955603

ID:: 304955603

SRA Run Selector

Select item 3049556026.

HEK293flpGR3KR_RNAseq_ML792-EtOH_rep2

Organism:: Homo sapiens

Source name:: Isogenic HEK293 cells, SUMOylation-defective GR (GR3KR), ML-792 + vehicle, RNA

Platform:: GPL18573
Series:: GSE64301 GSE64373

Download data: BEDGRAPH

Sample

Accession:: GSM4955602

ID:: 304955602

SRA Run Selector

Select item 3049556017.

HEK293flpGR3KR_RNAseq_ML792-EtOH_rep1

Organism:: Homo sapiens

Source name:: Isogenic HEK293 cells, SUMOylation-defective GR (GR3KR), ML-792 + vehicle, RNA

Platform:: GPL18573
Series:: GSE64301 GSE64373

Download data: BEDGRAPH

Sample

Accession:: GSM4955601

ID:: 304955601

SRA Run Selector

Select item 3049556008.

HEK293flpGR3KR_RNAseq_DMSO-Dex_rep2

Organism:: Homo sapiens

Source name:: Isogenic HEK293 cells, SUMOylation-defective GR (GR3KR), dex, RNA

Platform:: GPL18573
Series:: GSE64301 GSE64373

Download data: BEDGRAPH

Sample

Accession:: GSM4955600

ID:: 304955600

SRA Run Selector

Select item 3049555999.

HEK293flpGR3KR_RNAseq_DMSO-Dex_rep1

Organism:: Homo sapiens

Source name:: Isogenic HEK293 cells, SUMOylation-defective GR (GR3KR), dex, RNA

Platform:: GPL18573
Series:: GSE64301 GSE64373

Download data: BEDGRAPH

Sample

Accession:: GSM4955599

ID:: 304955599

SRA Run Selector

Select item 30495559810.

HEK293flpGR3KR_RNAseq_DMSO-EtOH_rep2

Organism:: Homo sapiens

Source name:: Isogenic HEK293 cells, SUMOylation-defective GR (GR3KR), vehicle, RNA

Platform:: GPL18573
Series:: GSE64301 GSE64373

Download data: BEDGRAPH

Sample

Accession:: GSM4955598

ID:: 304955598

SRA Run Selector

Select item 30495559711.

HEK293flpGR3KR_RNAseq_DMSO-EtOH_rep1

Organism:: Homo sapiens

Source name:: Isogenic HEK293 cells, SUMOylation-defective GR (GR3KR), vehicle, RNA

Platform:: GPL18573
Series:: GSE64301 GSE64373

Download data: BEDGRAPH

Sample

Accession:: GSM4955597

ID:: 304955597

SRA Run Selector

Select item 30495559612.

HEK293flpGR_RNAseq_ML792-Dex_rep2

Organism:: Homo sapiens

Source name:: Isogenic HEK293 cells, wild-type GR, ML-792 + dex, RNA

Platform:: GPL18573
Series:: GSE64301 GSE64373

Download data: BEDGRAPH

Sample

Accession:: GSM4955596

ID:: 304955596

SRA Run Selector

Select item 30495559513.

HEK293flpGR_RNAseq_ML792-Dex_rep1

Organism:: Homo sapiens

Source name:: Isogenic HEK293 cells, wild-type GR, ML-792 + dex, RNA

Platform:: GPL18573
Series:: GSE64301 GSE64373

Download data: BEDGRAPH

Sample

Accession:: GSM4955595

ID:: 304955595

SRA Run Selector

Select item 30495559414.

HEK293flpGR_RNAseq_ML792-EtOH_rep2

Organism:: Homo sapiens

Source name:: Isogenic HEK293 cells, wild-type GR, ML-792 + vehicle, RNA

Platform:: GPL18573
Series:: GSE64301 GSE64373

Download data: BEDGRAPH

Sample

Accession:: GSM4955594

ID:: 304955594

SRA Run Selector

Select item 30495559315.

HEK293flpGR_RNAseq_ML792-EtOH_rep1

Organism:: Homo sapiens

Source name:: Isogenic HEK293 cells, wild-type GR, ML-792 + vehicle, RNA

Platform:: GPL18573
Series:: GSE64301 GSE64373

Download data: BEDGRAPH

Sample

Accession:: GSM4955593

ID:: 304955593

SRA Run Selector

Select item 30495559216.

HEK293flpGR_RNAseq_DMSO-Dex_rep2

Organism:: Homo sapiens

Source name:: Isogenic HEK293 cells, wild-type GR, dex, RNA

Platform:: GPL18573
Series:: GSE64301 GSE64373

Download data: BEDGRAPH

Sample

Accession:: GSM4955592

ID:: 304955592

SRA Run Selector

Select item 30495559117.

HEK293flpGR_RNAseq_DMSO-Dex_rep1

Organism:: Homo sapiens

Source name:: Isogenic HEK293 cells, wild-type GR, dex, RNA

Platform:: GPL18573
Series:: GSE64301 GSE64373

Download data: BEDGRAPH

Sample

Accession:: GSM4955591

ID:: 304955591

SRA Run Selector

Select item 30495559018.

HEK293flpGR_RNAseq_DMSO-EtOH_rep2

Organism:: Homo sapiens

Source name:: Isogenic HEK293 cells, wild-type GR, vehicle, RNA

Platform:: GPL18573
Series:: GSE64301 GSE64373

Download data: BEDGRAPH

Sample

Accession:: GSM4955590

ID:: 304955590

SRA Run Selector

Select item 30495558919.

HEK293flpGR_RNAseq_DMSO-EtOH_rep1

Organism:: Homo sapiens

Source name:: Isogenic HEK293 cells, wild-type GR, vehicle, RNA

Platform:: GPL18573
Series:: GSE64301 GSE64373

Download data: BEDGRAPH

Sample

Accession:: GSM4955589

ID:: 304955589

SRA Run Selector

Select item 30495558820.

HEK293flpGR3KR_GR_ML792-Dex_rep2

Organism:: Homo sapiens

Source name:: Isogenic HEK293 cells, SUMOylation-defective GR (GR3KR), ML-792 + dex, GR ChIP

Platform:: GPL18573
Series:: GSE64301 GSE64373

Download data: BEDGRAPH

Sample

Accession:: GSM4955588

ID:: 304955588

SRA Run Selector

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